Endocrine Abstracts

The role of ghrelin in the pathogenesis of acromegaly is doubtful. Ghrelin also regulates glucose and adipose tissue metabolism. It has not been demonstrated whether it contributes to the development of metabolic complications of acromegaly.Aim: The aim of the study was to assess: (1) whether serum concentrations of total and acyl ghrelin in patients with acromegaly differ in relation to coexisting metabolic complications (hypercholesterolemia, hyperinsu...

Introduction: To date, only four tyrosine kinase inhibitors (TKIs) have demonstrated beneficial effect on progression free survival in advanced medullary thyroid cancer (MTC; vandetanib and cabozantinib) andradioiodine-refractory differentiated thyroid cancer (RR-DTC; sorafenib and lenvatinib). However, there is still lack of unequivocal proofs of their significant impact on overall survival. Therefore, treatment-related side effects and their potential impact on quality of li...

The Case Study: We report the case of a 68-year-old female referred to the E.R. department with severe neurological problems. Patient’s neurological status revealed that patient was disoriented in time and place, with emotional irritability and an asymmetric eye fissure, and not feeling well without any obvious reason. A preliminary CT scan with I/V contrast was done and acute neurological damage was excluded. In the lab, there were: hypokalemia, hypomagnesemia, increased...

Context: Both polycystic ovary syndrome (PCOS) and chronic autoimmune thyroiditis (AIT, Hashimoto disease) are common endocrinopathies and the AIT is the most prevalent cause of hypothyroidism in areas with sufficient iodine intake. Patients with PCOS are probably more susceptible to the development of autoimmune diseases. The data about the prevalence of AIT in PCOS is limited and it has not been assessed in the Polish population.The aims of the study w...

Background: TSH-suppressive therapy is widely used in treatment of thyroid differentiated carcinoma. A common consequence of therapy is subclinical hyperthyroidism which may cause dysfunction of cardiovascular system, metabolism and reduction of bone mass1. Thyroid hormones are also involved in regulation of brain function2. Therefore, it is not surprising that thyroid dysfunctions are associated with frequent comorbid cognitive dysfunctions and depressio...

There are much controversy adjuvant radioiodine treatment (131-I-th) in intermediate or low risk patients with lymph node micrometastases. The first results of ESTIMABL2 trial showed no radioiodine benefit in low risk DTC, however intermediate patients were not included in this study.Aim: Observational study was to evaluate effects of 131-I-th in intermediate/low risk DTC patients.Patients: There were 342 women (85%), the median ag...

Introduction: According to the literature, the CRH test has the highest specificity in excluding ECS (ACTH 93.9%, cortisol 89.4%). A combination of the high dose dexamethasone test (HDDST) and CRH/desmopressin test (CRH/desmopressinT) is used to increase the discriminatory capacity in ACTH-dependent CS.Objectives: This study aims to investigate the response to dynamic tests in ECS patients.Methods: 35 consecutive ECS patients were ...

Aim: To evaluate adiponectin and resistin levels and their relationship with various biochemical and metabolic and atherogenic parameters markers, as well as their correlation, and to investigate its contribution in pathogenesis of insulin resistance in cohort women with PCOS and of insulin resistance as well as in non-insulin resistant women with PCOS. Methods: This study was designed as a cross-sectional and involves 80 premenopausal women. Of these patients, 63 females have...

Controversy exists as to the best way to determine which thyroid nodules we should have fine needle aspiration (FNA). The lack of consensus in the British and American Thyroid Association guidelines has not helped to clarify this. The use of ultrasound scan (USS) determined U grading versus a composite of nodule size and pre-determined number of suspicious features continues to be debated. We therefore set out to compare the accuracy of U grading with other identified USS feat...

Patients with diabetes mellitus (DM) type 2 is a group of high cardiovascular risk. The incidence of coronary heart disease in their 2–4 times higher than in the population without diabetes, 80% of cases of diabetes combined with hypertension. At the same time any change in lipid metabolism leads to increased cardiovascular risk in patients with type 2 diabetes. Statins is first-line drugs in patients with dyslipidemia.Materials and methods: The stu...