Endocrine Abstracts

Background and aims: The safety of thyroid surgery in terms of recurrent laryngeal nerve palsy and hypoparathyroidism was increasing in the last decade. In this study, we present a new method of tension-free thyroidectomy (TFT), which could be used to further decrease the complication rate after thyroidectomy.Patients and Methods: TFT is based on the medial approach to the recurrent laryngeal nerve (RLN) and the parathyroid glands after the division of i...

Background: Bethesda IV is the most common indication for thyroid surgery. As histological verification is the only 100% certain method of confirming malignancy, surgery remains the gold standard for FN treatment. Most cases of FN malignancy are variants of papillary thyroid cancer that require active surveillance alone in nodules sized less than 2 cm.Materials: A continuous cohort of 4399 patients who underwent surgery at SPbU_Hospital in the years 2020...

Background: Hypoparathyroidism is one of the most important complications of total thyroidectomy. Its treatment with the use of recombinant parathyroid hormone (PTH) is limited now, therefore the prophylaxis of post-surgical hypoparathyroidism is very important. A method of tension-free thyroidectomy (TFT) was proposed in 2021. TFT uses unusual medial approach to the recurrent laryngeal nerves (RLN) and parathyroid glands (PG), together with several principles decreasing tract...

Background: Osteoprotegerin (OPG) is a bone-related glycopeptide produced by vascular smooth muscle cells due to arterial damage. OPG is considered as an independent predictor of cardiovascular disease in diabetic populations.The aim of this study was to evaluate the interrelation between circulating OPG and coronary vasculature damage in type 2 diabetes mellitus patients.Methods: One hundred and twenty six subjects with stable dia...

Background: Recent evidence has defined that circulating endothelial progenitor cells (EPCs) might have a pivotal role in the presence of atherosclerosis, chronically diseased vessels or following acute vascular injury. We hypothesized that diabetes mellitus (DM) may be related to worsening of ischemic chronic heart failure thereby suppression of mobilization of bone marrow-derived EPCs.The aim of this study was to evaluate predict value of circulating E...

Background Undetected multiglandular disease (MGD) is a leading cause of persistent primary hyperparathyroidism after surgical treatment. There is still a number of clinically significant parathyroid adenomas that remain unseen preoperatively.Materials and methods A retrospective cohort study was conducted in order to reveal factors associated with risk of MGD. 810 cases of pHPT patients who had received primary surgical treatment at SPBU Hospital in 201...

A decade of study has conclusively shown that the reproductive hormone kisspeptin is a critical regulator of the HPG axis acting in the hypothalamus to control GnRH secretion. More recently, the role of kisspeptin outside the HPG axis has received increasing attention with the emergence of associations between kisspeptin, brain processing and behaviour. In this talk, I will provide evidence from studies in rodents to humans, that collectively demonstrate that kisspeptin can in...

A decade of study has conclusively shown that the reproductive hormone kisspeptin is a critical regulator of the HPG axis acting in the hypothalamus to control GnRH secretion. More recently, the role of kisspeptin outside the HPG axis has received increasing attention with the emergence of associations between kisspeptin, brain processing and behaviour. In this talk, I will provide evidence from studies in rodents to humans, that collectively demonstrate that kisspeptin can in...

We are the first who studied the control and the role of transcription factors in the regulation of reproductive functions. Our presentation represents a short review of original data concerning external (temperature, calories restriction) and internal (hormones, protein kinases, RNA interference) in control of selected transcription factors (p53, NFkB, STAT1, CREB1), as well as their role in control of basic ovarian cell functions (proliferation, apoptosis, secretory activity...

Hypothyroidism in pregnancy is generally considered harmful. However, the definition of hypothyroid during pregnancy remains controversial. Measurements of maternal serum TSH have traditionally been used to define hypothyroidism, with values >2.5 mIU/l generally warranting treatment. However, recent data have suggested that the ‘normal’ reference range for serum TSH in healthy pregnant women varies by region as well as by ethnicity. Importantly, changing the uppe...