Endocrine Abstracts

Aim: To determine the incidence of hypocalcaemia and the need for calcium supplementation after thyroid surgery in 120 patients.Methods: A prospective study to determine the incidence of hypocalcaemia by measuring ionized calcium level in 120 patients underwent thyroidectomy at King Abdul Aziz University Hospital, the data included pre- and post-operative ionized calcium level, albumin, free thyroxine, thyrotopin and alkaline phosphatase. As well include...

Authors: Mohamed Coco, Katrina Sheikh, Basheir Osman, Jayadave Shakher: Department of Acute Internal Medicine, Birmingham Heartlands Hospital-University Hospitals BirminghamIntroduction: Although skeletal metastatic diseases have commonly been associated with hypercalcemia; we present a case of severe hypercalcemia secondary to extensive skeletal sclerotic metastatic disease.Case: ...

Adrenal gland is a less focused endocrine organ for the endocrine disrupting effect of endocrine disrupting chemicals (EDCs). The effects of two extensively used phthalate esters viz. di-ethyl hexyl phthalate (DEHP) and di-butyl phthalate (DBP) on adrenal gland were observed in Wistar rats in the present study to check the susceptibility of adrenal gland against the exposure of these extensively used plasticizers which are well known EDCs. Wistar rats were divided into seven g...

A female patient in her early forties was referred to the endocrine clinic. She initially presented to her general practitioner with symptoms of leg cramps and feeling lethargic. As part of initial investigation, thyroid function tests were performed which revealed Free T4 >100 pmol/lwith a TSH suppressed <0.02mU/l. She was promptly commenced on carbimazole for thyrotoxicosis. On retrospective questioning, there was history of weight loss greater than one stone, over t...

Limited research has been conducted on adrenal gland as target of endocrine disrupting chemicals (EDCs). Moreover, studies on steroidogenesis as the target of EDCs has also attracted lesser attention compared to other metabolic pathways. We studied the effects of two extensively used phthalate esters viz., di-ethyl hexyl phthalate (DEHP) and di-butyl phthalate (DBP) on the adrenal gland in Wistar rats and checked its susceptibility against the exposure of these extensively use...

We describe the case of a 52-year-old female, with a body mass index of 32 kg/m2 and without significant co-morbid illness who initially presented acutely, with self-resolving abdominal pain. During that admission, an abdominal computed tomography (CT) scan demonstrated a right-sided heterogeneous and contrast enhancing adrenal mass (measuring 59×41 mm) with a 15 mm focus of cystic degeneration. Based on the scan appearances, the patient was suspected as having...

Introduction: Congenital adrenal hyperplasia (CAH) due to 21 hydroxylase deficiency is one of the most common autosomal recessive hereditary diseases. There are two main forms of CAH: early onset, the classic variety, and late onset or non classic type. Here, we aim to describe the case of a young lady with features of both varieties of CAH.Case report: Twenty-three-year-lady of Asian descent presented with polymenorrhagia since menarche (age 13 years), ...

Introduction: Autoimmune polyendocrine syndrome type II (APSII) is more common than APSI. It occurs more frequently in female than in male patients, often has its onset in adulthood, and has familial aggregation. Schmidt’s syndrome is a subset of APSII, usually associated with primary hypothyroidism, primary adrenal insufficiency, and often, type 1 diabetes. This case describes the interesting evolution of autoimmune polyendocrine disease (APED) in a young lady with long ...

ImportanceThere remains uncertainty about the impact of menopausal hormone therapy (MHT) on women’s health. A systematic, comprehensive assessment of the effects on multiple outcomes is lacking.ObjectiveTo comprehensively summarize evidence on the benefits and harms of MHT across diverse health outcomes in women.Data sourcesMEDLINE, EMBASE and 10 other databa...

Background: Non-islet-cell tumour hypoglycaemia (NICTH) is a rare paraneoplastic syndrome caused by an extra pancreatic tumour(1). Solitary fibrous tumour (SFT), amongst other tumours, is one of the rare causes of NICTH. We report a case of NICTH who presented with recurrent hypoglycaemias and was identified to have a fibrous tumour as part of the work up for his symptomatic hypoglycaemias.Case Summary: A 75-year male had presented to the emergency depar...