Endocrine Abstracts

The transcription factors Runx2 and osterix (Osx), which are known as downstream genes in BMP2 pathway, are essential for osteoblast differentiation and bone formation. Runx2 expression is normal in Osx null mice, but Osx is not expressed in Runx2 null mice, indicating that Osx acts as a downstream of Runx2. Here, we questioned whether or not all bones could be formed by BMP2–Runx2–Osx pathway or unknown their own gene axis. To answer this question, we first analyzed...

Background: The elevation of serum immunoglobulin E (IgE) has been recently reported to be associated with Graves’ disease (GD). Interleukin 13 (IL-13) is a major cytokine involved in IgE synthesis and therefore may be a potential candidate gene influencing the clinical course of the GD. The aim of this study are to evaluate whether the atopic parameter such as total IgE is related to TSH receptor antibody (TRAb, thyrotropin-binding inhibitory immunoglobulin: TBII) and wh...

Runx2 and Osterix(Osx) have been known as the master transcription factors for bone formation. However, genes that act downstream of both Runx2 and Osx have not been fully studied. To investigate downstream target genes of Runx2 and Osx, DNA microarray was conducted in calvaria of WT, Runx2ΔC/+, Osx+/−, and Runx2ΔC/+; Osx+/− double heterozygous mice designated WT, Runx2het, Osxhet, and Doub...

Osterix (Osx) is an essential transcription factor for osteoblast differentiation and bone formation. Osx null mutants died perinatally with a complete absence of bone formation and Osx conditional knockouts in osteoblasts showed the osteopenic phenotype after birth. Even in Osx heterozygous mice with normal bone morphology, the reduced cortical thickness and osteoblast differentiation were observed by QCT and in vitro cell culture, respectively. This result exhibited t...

Objectives: Various systemic symptoms may occur in patients with thyrotoxicosis. Gastrointestinal manifestations such as hyperphagia or frequent defecation, often coexist with other thyrotoxic symptoms. Vomiting also has been mentioned.In this setting, systemic symptoms of underlying malignancy may be confused with those of thyrotoxicosis leading to a delay in diagnosis.Methods: We report a case with delayed diagnosis of small bowe...

Introduction: There are few cases about arterial thrombosis combined with thyrotoxicosis independent of atrial arrhythmias. Herein, we report a case of Graves’ disease presented with renal artery infarction withiout atrial fibrillation.Case: A 54-year-old man visited the emergency department due to the sudden onset of left flank pain for 30 min. The left flank pain was accompanied by sole dysuria without other symptoms of pyelonephritis. Physical ex...

Introduction: The degree of dyslipidemia caused by iatrogenic hypothyroidism is not clear in DTC. Therefore, we investigated the average of lipid profile change caused by LT4 withdrawal in the follow-up of DTC.Method: We enrolled 84 DTC patients who underwent high-dose RAI therapy for the treatment of recurred or remnant DTC and we measured serum levels of total cholesterol, triglyceride, LDL, and HDL and then analyzed changes in them accordin...

Introduction: Transoral Robotic Thyroidectomy (TORT) is progressively gaining its ground in robotic thyroid surgery. With accumulated techniques and developments, TORT can also be applied for completion thyroidectomy. We review our experience with the transoral robotic approach to completion thyroidectomy to evaluate the safety and surgical feasibility.Methods: Consecutive patients receiving completion TORT operation were evaluated from a prospective dat...

Objectives: Radioactive iodine (RAI) therapy has potential therapeutic effects in treating Graves’ disease (GD). However, whether RAI therapy for GD can increase cancer risk remains a controversial issue in medicine and public health.Methods: Using the Korean National Health Insurance Service-National Health Information Database (NHIS-NHID, 2002–2020), we investigated hazard ratios (HRs) of overall and site-specific cancer associated with RAI i...

Background: Although sclerostin (SOST) and Dickkopf-related protein 1 (DKK1) are major regulators in bone metabolism, the associations between these soluble Wnt antagonists and osteoporotic fracture (OF) in Asians, who may have distinct biologic characteristics with Caucasians, are inconclusive. Furthermore, there have been no clinical studies separately considering non-vertebral and vertebral fractures in terms of the blood levels of SOST and DKK1.Metho...