Endocrine Abstracts

Triorganotins, such as tributyltin (TBT), are environmental contaminants commonly found in antifouling paints that are used on the ships and other vessels. Unfortunately, these chemical are also suspected to cause endocrine-disrupting effects in mammals, due in part to their possible transfer through marine food chains and to the consumption of contaminated seafood. The importance of triorganotins as environmental endocrine disruptors in different animal models is well known; ...

Connexins are a proteins critically involved in the formation of gap junction, which connect cells with each other and enable the exchange of small compounds and, besides having a role independently of gap junction formation. At least, in the anterior pituitary two cellular networks have already been identified, one of them is composed of the endocrine inactive folliculo-stellate cells and the second one is the GH-producing somatotroph cell network. It is supposed that gap jun...

Proper classification of pituitary adenomas (PA) is an important area of research. Thus, developing of new biomarkers is essential to facilitate the early detection of PA, identify the drug response and predict recurrence reliably in all patients. The usual histological markers of tumor aggressiveness and/or invasiveness are often similar between recurring, regrowing, and stable tumors, and therefore are not reliable as prognostic parameters. To quantitate the levels of the HM...

Introduction: Functional hypothalamic amenorrhea (FHA) is one of the most common causes of secondary amenorrhea. There are three types of FHA: weight loss-related, stress-related, and exercise-related amenorrhea. The latter is fairly common among competitive athletes. Currently the Olympic Committee includes amenorrhea in the “Relative Energy Deficiency Syndrome in Sport (RED-S)”. The syndrome of RED-S refers to impaired physiological function including metabolic rat...

Background: Pregnant women with gestational diabetes (GD) have a higher risk of perinatal complication compared to women without. Nevertheless, in women with GD, predictors of perinatal complication are not well established. We aimed to compare, in women with GD, those with and without perinatal complications and to study predictors of perinatal complications in women with GD.Methods: Retrospective study of pregnant women followed in the Endocrinology cl...

Introduction: Pasireotide long acting release (LAR) is approved for second line treatment of acromegaly. We present 3 patients with aggressive acromegaly treated with a personalized de-escalation approach.Case 1: A 61-year-old female affected by acromegaly reisistant on first-line SSAs. In 2015 therapy was switched to pasireotide LAR 60 mg every 28 days. After two years, the IGF-I level touched the lower age range and therapy was downscaled to pasireotid...

Introduction: The small-cell neuroendocrine prostate carcinoma (SCPC) is rare, highly aggressive and usually transforms from prostate adenocarcinoma (PAC) after androgen deprivation therapy (ADT).Case Report: A 66-year-old man had a three-year history of high-grade PAC with high burden disease (abdominal lymph node and bone metastasis) at presentation (09/2019). On the initial staging evaluation, the CT scan documented a 20 mm left adrenal nodule compati...

Objectives: The clinical significance of antithyroglobulin antibody (TgAb) levels verified concomitantly with undetectable thyroglobulin (Tg) during the follow-up of patients with differentiated thyroid carcinoma remains under debate. The present study aimed to evaluate the presence and prognostic predictive value of TgAb during the follow-up of patients with differentiated thyroid carcinoma.Methods: A retrospective cohort study was performed by reviewin...

Introduction: Kallmann-de Morsier Syndrome is a rare genetic disorder characterized by the combination of hypogonadotropic hypogonadism and anosmia or hyposmia. It is more prevalent in males compared to females. In this case report, we present the case of an adolescent with Kallmann-de Morsier Syndrome.Case Presentation: An 18-year-old patient was referred to our endocrinology clinic by gynecologists for the investigation of pubertal delay. The patient&#...

Introduction: Male hypogonadotropic hypogonadism (HH) is a consequence of congenital or acquired diseases that affect the hypothalamus or the pituitary gland. In HH, secretion of gonadotropin releasing hormone (GnRH) is absent or inadequate. Diagnosis during adulthood (after normal puberty) suggests an acquired etiology. Acquired hypogonadotropic hypogonadism can be caused by drugs, infectious or infiltrative lesions, systemic diseases, radiation and TBI. Post-TBI neuroendocri...