Endocrine Abstracts

-Diana Borges Duarte and Francisca Puga are joint first authors and contributed equallyBackground: As therapeutic options improve for Cushing’s disease (CD), most patients can now achieve control or cure of hypercortisolism. However, persistent complaints are often reported. Evaluation of health-related quality of life (HR-QoL) can highlight impairments beyond the stricter clinical aspects. Our aim was to evaluate HR-QoL with a specific focus on men...

The Polymerase Chain Reaction is going through a renaissance with the arrival of new Digital PCR instrumentation. Amongst these, Droplet Digital PCR is embraced by the research community as an affordable, high resolution quantitative and detection analysis solution for nucleic acids. This presentation will cover the concept of digital PCR, absolute and standard free quantitation of nucleic acid targets as well as applications; CNV analysis, Mutation Abundance, Single cell expr...

Hormone release by pituitary cell types is primarily regulated by stimulatory and inhibitory factors secreted by the hypothalamus. In turn, factors produced by the target organs controlled by the pituitary exert a feedback regulation on the corresponding pituitary cells. However, recent data indicate that, besides these factors, other mechanisms operate to finely tune pituitary function. These include both novel peripheral regulatory factors as well as intrinsic cellular eleme...

Introduction: The small-cell neuroendocrine prostate carcinoma (SCPC) is rare, highly aggressive and usually transforms from prostate adenocarcinoma (PAC) after androgen deprivation therapy (ADT).Case Report: A 66-year-old man had a three-year history of high-grade PAC with high burden disease (abdominal lymph node and bone metastasis) at presentation (09/2019). On the initial staging evaluation, the CT scan documented a 20 mm left adrenal nodule compati...

Introduction: The 22q11.2 deletion syndrome or DiGeorge syndrome (DGS) is rare and the diagnosis in adults is uncommon. The phenotype is highly heterogeneous and of variable severity, including hypoparathyroidism and epilepsy.Case Report: A 26-year-old man was admitted in the emergency room for inaugural tonic-clonic seizure. He had history of cognitive impairment and learning difficulties. Neurologic examination, brain CT and basic analysis were irrelev...

Introduction: Follicular thyroid cancer (FTC) accounts for 12% of differentiated thyroid cancers (DTC). It is frequently complicated by bone metastasis (BM), which impact quality of life (QOL) and decreases the 10-year survival rate to 13-21%.Case Report: A 53-year-old woman followed at the Pain Clinic for over 10 years for lower back pain, had been operated three years before due to lumbar disc herniation. Pain relapsed one year after surgery and was re...

Objectives: To determine the association between adverse pregnancy outcomes with each of the 75 g OGTT cut-off values prescribed by the World Health Organization (WHO), Philippine Obstetrical and Gynecological Society (POGS), and the International Association of Diabetes in Pregnancy Study group (IASDPG) criteria to help define more appropriate glycemic cut-off levels for Filipinas.Methodology: Retrospective Cohort study of pregnancy deliveries in De La ...

Type 1 diabetes mellitus (T1D) is an autoimmune disease that results from the destruction of insulin producing β cells, in genetic susceptible individuals. Vitamin D (Vit D) is mostly known for its role in bone and calcium metabolism, however it is also involved in the modulation of the immune response. Serum levels of vitamin D partly depend on diet and sunlight exposure. However, genetic factors are also involved. Patients with T1D have been reported to have a higher pr...

Introduction: Gestational diabetes mellitus (GDM) is a carbohydrate intolerance with onset or recognition during pregnancy. Timely screening and proper management of this condition is essencial to maximize pregnancy and neonatal outcomes.Methods: Retrospective analysis of all cases of GDM, and the respective new-borns, followed in our obstetrics unit between 2012 and 2015. Clinical and workup parameters were evaluated.Results: From...

Introduction: Gestational Diabetes Mellitus (GDM) is a pregnancy complication that has experienced a worldwide growth. The use of insulin has to be considered as it may be beneficial for both the mother and the new-born.Methods: Retrospective analysis of all cases of GDM, and the respective new-borns (NB), followed in our obstetrics unit between 2012 and 2015. Clinical and workup parameters were evaluated in 2 groups: GDM with no insulin therapy (GDMNIT)...