Endocrine Abstracts

Background and aims: To study the need for insulin during pregnancy, depending on the duration of the disease.Methods: We studied 108 pregnant women with DM 1 receiving insulin with insulin pumps. Patients were divided into three groups: in the 1st group diabetes duration was less than 5 years, in the 2nd – 5 to 15 years, 3rd – more than 15 years. We evaluated the daily need for insulin on 12, 22–25, 30–32 weeks of gestation.<p cl...

Vitamin D deficiency is associated with the development of some cancers and in vitro 1,25-dihydroxyvitamin D (1,25D) reduces cell proliferation. We suggest that modification of tissue specific immune responses, as a consequence of local synthesis of 1,25D, may be key. To assess the impact of serum 25D on the risk of bladder cancer we conducted a systematic review. To test our hypothesis, expression of vitamin D signalling components and the synthesis of 1,25D were exa...

Objectives: The aim of study was to examine the levels erythropoietin in hypothyroidism with anemic syndrome of different ages.Methods: We investigated 52 patients with hypothyroidism with irondeficiency normochromic and hypochromic anemia. Among them were 21 patients between ages from 21 to till 45 years old and 31 over 45 years of age. Examination included total blood, in the blood levels of thyroid hormones, serum iron, erythropoietin, ferritin by sta...

Introduction/objective: The exact mechanism of autoimmune thyroid destruction in patients with Hashimoto’s thyroiditis (HT) remains unclear. Recently it has been found that the HT patients demonstrate increased levels of anti-DNA antibodies, which may be directed against various nuclear structures and may be involved in process of apoptosis. In this study, we examined the potential association between anti-DNA antibodies levels, thyroid function and activity of autoimmune...

Objective: To study the effect of age and gender on manifestation of hyperprolactinaemia.Methods: Patients were examined using generally accepted methods of diagnosis. 207 patients with prolactinomas were divided into two groups: before and after 50 years. It was a retrospective study with no interventions to generally accepted methods of diagnosis and treatment. The outcomes were measured by frequency of hyperprolactinaemia symptoms according to age and...

Aim: To estimate pituitary disfunction development in patients with micro and macroadenonas before and after transnasal adenomectomy.Methods: A total of 222 patients at the age from 17 to 71 with pituitary adenomas were operated from 2007 to 2013. According to size the pituitary adenomas were classified as microadenomas (diameter less than 10 mm) and macroadenomas (more than 10 mm). Dynamic observation and redetermination of all hormones were performed w...

Introduction.: Circulating prolactin is predominantly monomeric, but when there presents more than 60% of polymeric, less bioactive forms, phenomenon of macroprolactinemia is diagnosed.For prolactinomas, serum prolactin levels generally parallel to tumor size, but tumor mass and prolactin levels may be dissociated due to hook-effect, when falsely low prolactin level observed. It is excluded by serial dilutions of serum samples.The ...

The purpose of study was to examine the content of gastrointestinal hormones in patients with hypothyroidism.Objectives and methods: We investigated of 37 patients, which hypothyroidism, at the age from 23 to 65 years. The diagnosis of hypothyroidism was confirmed by measurement of thyroid hormones and TSH in serum. Immunohistochemistry in gastrobiopsies of the antrum of patients studied gastrin, serotonin, melatonin. The primary antibodies used commerci...

Aim: The aim of the study was to evaluate the clinical efficacy of melatonin in patients with hypothyroidism.Materials and methods: In study were taken 51 patients from 25 to 63 years to manifest hypothyroidism (on a background of autoimmune thyroiditis), with anxiety-depressive syndrome and sleep disturbance. Thyroid hormones were determined by ELISA (Vector-Best Russia) Anxiety-depressive syndrome in patients with hypothyroidism were analyzed on hospit...

Background: Exercise training has become an important adjunct therapy for both the prevention and management of type II diabetes mellitus. Interest in telemedicine is increasing as a potentially innovative and sustainable intervention approach to diabetes management. Telemedicine can facilitate the achievement of individualized treatment goals by training patients to manage their own disease.Objective: To evaluate the effect of telemedicine on exercise c...