Endocrine Abstracts

Kalach 360 SL (KL), glyphosate (G) surfactant-based herbicides, is a systemic herbicide effective against weeds. It was applied in agriculture in Tunisia and throughout the world, which can represent a risk to non-target organisms. The aim of this study was to investigate the morphological and biochemical aspects of ovary injury after exposure to KL. Female Wistar rats were divided into three groups: group 1 was used as a control; group 2 orally received 0.07 ml of KL, (126 mg...

Vasopressin (VP) and oxytocin (OT), the antidiuretic and natriuretic hormone, respectively, maintain the osmotic homeostasis. These molecules are synthesized in the magnocellular neurons (MCNs) of the supraoptic nuclei (SON) in the hypothalamus, transported via the axons toward the neural lobe of hypophysis (NLH) and released into the blood stream.Dp71 is the major form of dystrophins in the SON and NLH, where it was located in the glial-end-feet and end...

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in females of reproductive age. It is frequently associated with metabolic disturbances and insulin resistance, that occurs in about 50–70%. Evidences were reported about the association between vitamin D and osteocalcin with cardiovascular risk factors, regulation of insulin secretion and sensitivity.Objectives: Evaluation of the association between of low 25-hydroxyvitamin...

Introduction: Micropenis represents a diagnostic and therapeutic challenge. The Diagnosis is based on the measurement of penile length. Defined by normal structure, abnormal size: -2 standard deviation (SD) below of average of age. The aim of our study is to evaluate the etiological profile and therapeutic efficacy.Patients and methods: It’s a retrospective and descriptive study including 55 childrens and adolescents with micropenis, treated with ho...

Introduction: Precocious puberty results from the premature activation of the gonadal axis. It mimics physiological pubertal development, although at an inappropriate chronological age (before 8 years in girls and 9 years in boys). It is a serious challenge with repercussions on physical and psychosocial development. We aimed to evaluate the different etiology of Precocious puberty and the effectiveness of the Gonadotropin-releasing hormone (GnRH ) agonists.<p class="abste...

Introduction: Hypothyroidism is a state of hypometabolism at the origin of numerous metabolic disturbances, including dyslipidemia, which may increase cardiovascular risk in these patients. The aim of our study is to assess the lipid profile in patients with peripheral hypothyroidism.Materials and methods: Retrospective descriptive study including 130 patients, followed at the Endocrinology-Diabetology and Nutrition Department of the University Hospital ...

Introduction: During pregnancy, women experience various physiological changes that can impact them psychologically. Lifestyle modifications such as eating behaviors and physical activity during this period are major determinants of pregnancy outcomes, child development, and maternal health. Also, body transformations during this period could reactivate concerns regarding body image and introduce anxiety, body dissatisfaction, and eating behavior issues. The aim of our study w...

Introduction: Methimazole is a widely prescribed antithyroid drug for the treatment of hyperthyroidism with a few adverse effects generally well-tolerated. However, methimazole-induced cholestatic jaundice (CJ) is a rare but serious adverse reaction. Herein we report a rare case of methimazole-induced CJ in a woman with hyperthyroidism.Case report: A 57-years-old women presented to our endocrinology department with a 2-week history of asthenia, insomnia,...

A 71 year old gentleman presented with polydipsia, polyuria and nocturia for two weeks and weight loss of 10.5 Kg over the preceding two years. He had hypertension controlled with valsartan, hydrochlorthiazide, amlodipine and doxazosin. His average alcohol intake was 55 units per week. His brother had diabetes of uncertain aetiology. Examination was unremarkable apart from mild dehydration. His body mass index was 28 kg/m2 and there...

A 71 year old gentleman presented with polydipsia, polyuria and nocturia for two weeks and weight loss of 10.5 Kg over the preceding two years. He had hypertension controlled with valsartan, hydrochlorthiazide, amlodipine and doxazosin. His average alcohol intake was 55 units per week. His brother had diabetes of uncertain aetiology. Examination was unremarkable apart from mild dehydration. His body mass index was 28 kg/m2 and there...