Endocrine Abstracts

Purpose: Papillary thyroid cancer (PTC) has a strong propensity for lymph node metastasis, which is related with local recurrence, and disease-specific survival in the elderly. We evaluated the association between lymph node metastasis and disease multifocality, bilaterality, and other clinicopathological variables to identify risk factors and aid surgical decision-making. The relationship between the number of foci and metastasis to cervical lymph node was also evaluated....

Background: To date, no staging system has been related to the number of metastatic lymph node or lymph node ratio. Lymph node ratio (LNR) was defined as the number of metastatic LNs divided by the total number of LNs dissected. The purpose of this study was to determine how central LNR had a prognostic value to predict recurrence in N1b papillary cancer.Methods: This study included 331 patients who underwent total thyroidectomy with lateral neck dissect...

Background: The prevalence of diabetes in South Korea has drastically increased, and 8.6–11.0% of Korean adults aged ≥30 years were suffering for the disease in the early 2000s, according to the Korea National Health and Nutrition Examination Survey.Objective: The present study was performed to estimate the incidence and prevalence of type 2 diabetes mellitus (T2DM) and its complications in South Korea using the Health Insurance Review and Ass...

A 54-year-old gentleman presented with increased urinary frequency, urgency and nocturia. His GP treated him for benign prostatic hypertrophy with tamsulosin. When this failed to alleviate his symptoms he was referred to urology. Investigations revealed he was drinking in excess of 6 litres of fluid per day, hence he was referred to endocrinology.Aside from a 6-month history of polyuria and polydipsia, there was no history of previous head injury, headac...

Purpose: Denosumab is a monoclonal antibody that prevents osteoclast development. The effect of denosumab in solid organ transplant recipients has been elucidated, but the effect of denosumab in hematopoietic stem cell transplantation recipients has not been studied yet. Thus, the aim of this study was to determine the effectiveness and safety of denosumab in hematopoietic stem cell transplantation recipients.Methods: We retrospectively evaluated 27 pati...

Subcutaneous ossifications (SCO) represent a recognized manifestation of pseudohypoparathyroidism type 1A (PHP1A) and pseudopseudohypoparathyroidism (PPHP), posing significant morbidity to affected individuals. This report details the case of a 37-year-old woman with PHP1A with extensive scalp calcifications, an unusual and unexpected finding. The patient presented with multiple firm skin nodules on the right knee and dorsum of both hands. Having been diagnosed with hypothyroi...

We present a case of a 54-year-old man who was urgently referred to A&E by his general practitioner with very low calcium of 1.32 mmol/l (normal 2.20–2.60 mmol/l). His only past medical history of note was of recently diagnosed multiple sclerosis (MS), which presented as optic neuritis six months ago. His initial investigations included high phosphate level of 2.0 mmol/l (normal 0.8–1.5), normal vitamin D levels (76 mmol/l) and a very low 24-hour urine calcium of...

Increased deposition of extracellular matrix (ECM) components such as collagens and hyaluronan is associated with diet-induced insulin resistance (IR) in skeletal muscle. Studies of the role of specific ECM components in muscle IR have been pivotal but incomplete. Here we used an approach (i.e. ECM-specific mass spectrometry-based proteomics) that gives a more complete view of ECM protein abundance with muscle IR. Male C57BL/6 mice were fed with either a chow or high fat (HF) ...

Introduction: Myxodedema coma comprises a complex endocrinological emergency whereby there is severe clinical hypothyroid state. It is a life threatening yet a potentially reversible condition that may prove rather difficult to recognise due to the complex symptomatology. Very few articles report the specific therapy for myxoedema coma.The case: Here we present an elderly lady with previous total thyroidectomy, who despite receiving oral thyroxin tablets...

Resveratrol (trans-3,4,5-trihydroxystilbene, RES), a phytoestrogen, exists in grape skin and red wine. Endocrine disrupting chemicals (EDCs) appear to promote the development and progression of the estrogen dependant cancers. In this study, we evaluated the inhibitory effect of RES on the cell growth and progression induced by various EDCs in BG-1 ovarian cancer cells expressing estrogen receptors (ERs). The various EDCs, i.e., bisphenol A (BPA), nonylphenol (NP), octylphenol ...