Endocrine Abstracts

Introduction: Atypical parathyroid tumour (APT) is a rare cause of primary hyperparathyroidism (PHPT) with a frequency of 1.2-1.3%. APT is a lesion with suspicious clinical and histological features of malignancy which does not completely respect the World Health Organization (WHO) criteria for diagnosis of Parathyroid Carcinoma (PC). There is a well-known association with PHT and medullary thyroid carcinoma for multiple endocrine neoplasia. However, concurrence of thyroid pap...

Introduction: Type two diabetes (T2DM), is the most common form of diabetes and known to be associated with low-grade inflammation. Since TLR-4 plays an important role in bacteriel recognition of lipopolysaccharide (LPS) and activation of proinflammatory pathways we aimed of to test whether TLR-4 gene polymorphism plays a protective role in the development of T2DM in a pilot Turkish population.Description of methods/design: Blood samples were collected f...

Introduction: Recently, Programmed cell death ligand 1 (PD-L1) inhibitors have been frequently used as promising treatment options for some advanced malignancies. Although immune-related side effects secondary to PD-1 inhibitor treatment are well defined in the literature, data on PD-L1 inhibitors are limited. Thyroid dysfunction was reported in 10% of patients in the clinical study of atezolizumab. We aimed to present a case of severe hypothyroidism-related rhabdomyolysis and...

Background: Thyroid nodules diagnosed as Bethesda category IV (follicular neoplasm/suspicious for follicular neoplasm (FN/SFN)) are recommended for surgery. However, only 25% of these nodules turn to be malignant on histopathology. Therefore, selection of nodules for surgery diagnosed as Bethesda category IV is important. We aimed at to define the predictive factors for malignancy and predictive risk indices for selection of surgery.Method: The records o...

ObjectiveThis was a systematic review with meta-analysis aiming to identify if patients with Klinefelter syndrome (KS) had a reduced full scale intelligent quotient (IQ) when compared to controls. Reduced IQ is shown to have a negative multifaceted effect on individuals’ Quality of Life (QoL), having been shown as a predictor of future success, increased criminal behaviour, post-traumatic stress disorder (PTSD), lower academic achievements and i...

Introduction: Thyroid ophthalmopathy occurs generally due to Graves’ disease. Only a few cases were reported about ophthalmopathy in the years following a thyroidectomy and RAI therapy or metastatic papillary thyroid cancer.Case: A forty-six-year-old female patient was operated on for the fine needle aspiration biopsy (FNAB) result of a suspicious follicular neoplasia. A pathology examination showed a papillary microcarcinoma and Hashimoto thyroidit...

Purpose: Cocaine and amphetamine-regulated transcript (CART) influences the appetite, obesity and pancreatic functions. The aim of this study is to determine the CART level of patients with PCOS and examine the relation with the insulin resistance in patients with PCOS.Methods: 41 patients with PCOS and and 39 healthy women were included in the study whose age and BMI matched. For PCOS diagnosis, 2003 Rotterdam criteria were used. The fasting serum gluco...

Introduction: Lipocalin-2 is abundantly expressed in mature adipocytes and causes insulin resistance. In the physiopathology of PCOS, insulin resistance has great importance. The purpose of this study was to determine serum lipocalin-2 levels in patients with PCOS and to investigate its relationship with body fat percentage, hs-CRP and insulin resistance.Methods and designs: This study was planned as a case controlled study. We enrolled 44 women with PCO...

Objective: The red blood cell distribution width (RDW) is being recognized as a global marker of chronic inflammation, high level of oxidative stress, and cardiovascular disease risk. We aimed to investigate the relation between the level of RDW and highly sensitive C-reactive protein (hs-CRP), insulin resistance, BMI and body fat percentage in women with polycystic ovary syndrome (PCOS).Methods: Cross-sectional study of 90 PCOS (2003 Rotterdam Consensus...

Hirsutism, development of terminal body hair in women in unexpected areas, may result from different etiologies; 4.3% being nonclassical congenital adrenal hyperplasia (NCCAH) and acromegaly being one of the rarests. We here present a severe hirsutism case with acromegaly and NCCAH.Case: A 30-year-old woman with headache and visual field abnormalities was consultated by our clinic about her cranial imaging revealing a macroadenoma in pituitary localizati...