Endocrine Abstracts

Introduction: The problem of postoperative hypothyroidism has the same long history as thyroid surgery. Levothyroxine monotherapy is the treatment of choice for hypothyroid patients because peripheral T4 to T3 conversion is supposed to account for the overall tissue requirement for thyroid hormones.The aim of this retrospective study conducted in the hospital is to evaluate the effectiveness of levothyroxine monotherapy in patients ...

Vologda is situated in the North-Western region of Russian Federation. It is mostly rural – about 30% of population lives in remoted villages. One can compare Vologdàs region with Greece – same amount of land area (approximately 140000 m2), but the population density is 10 times less (8 per km2 and 85 per km2 respectively). The Vologdàs region population is approximately 1151000, the amount of Diabetes patients is 42 000 (3,7% of overall population). The te...

Background/Aim: Impact of age on hypothalamic –pituitary –thyroid axis, interesting from theoretical and practical aspects, have been studied. Our aim was to find out: correlation between T3 (triiodothyronine) and T4 (thyroxine) hormone level and old age, so as of other, for thyroid function relevant parameters: TSH (thyroid stimulate hormone), TRH (thyreothropin releasing hormone) test, thyroid ultrasonography, thyroid gland scintigraphy with 131 J, ...

Purpose: The goal of the study was to determine: existence and degree of diabetic cardiovascular autonomic neuropathy (DCAN) depending on the type of diabetes; influence on systolic and diastolic function of myocardium and correlation with coronary disease and cardiovascular risk factors; possibility of early detection and diagnostic value of cardiovascular tests (CVT).Methods: The study involved 90 participants: 30 patients with type 1 diabetes (T1DM), ...

Background/Aim.: Importance of glucoreglation qality in diabetes complication prevention was proven in numerous clinical studies. Aim of this study is to determine impact of glucoregulation and duration of diabetes on the incidence of chronic complications of diabetes in Republic of Srpska (RS).Method: Study model included subjects with T1D and T2D who participated in the two-year project in the RS. It was a cross-sectional study with 10...

Microcirculatory disorders play important role in pathogenesis of diabetic vascular complications.Aim: to study peculiarities of microcirculatory haemostasis (tromboresistance of vessel wall and functional activity of thrombocytes) in adolescents with type 1 diabetes mellitus (T1DM). Patients and methods120 adolescents (55 boys, 65 girls) 12–17 y.o. with T1DM were examined. The duration of the disease was: less than 1 year - in 42 patients (HbAc1 7....

Despite significant progress in understanding the regulation of phosphate (Pi) homeostasis over the past 20 years, the mechanisms underlying the very early step leading to the regulating cascade involving multiple hormones (PTH, vitamin D, FGF23) and organs (kidney, intestine, bone, parathyroid glands) are not deciphered. Progress in this area is based on on the ability to identify and characterise the Pi-sensing mechanism in mammals that allow cells or organisms to detect cha...

Background: An increased incidence of thyroid cancer among young population of contaminated territories of Russia after Chernobyl accident made very important morphological verification of diagnosis. Many epidemiological and molecular studies of post-Chernobyl thyroid cancer conducted by various research teams required an independent review of tumour histology. The International Pathology Panel formed consensus diagnosis for each case of post-Chernobyl thyroid tumours and prop...

Background /aim: Osteoporosis is a generalized bone disease, characterized by impaired bone firmness, resulting in an increased predisposition for fractures. In order to detect the subjects at risk for fractures, one should actively search for them, primarily in a group of postmenopausal women, considering clinical risk factors. Apart from others, the relevant risk factors are lack of estrogen and low body mass index (BMI <19 kg/m2).: The aim of this study was t...

Aim: To determine the effect of socioeconomic and educational status on metabolic control in T2D patients in Republic of Srpska (RS)Subjects and method: This is a cross–sectional study of 1088 subjects aged 18 or higher who were randomized from primary care physicians’ T2D diabetes registries. Socioeconomic, educational, anthropometric and metabolic characteristics of T2D patients were analyzed.Results: Highest proporti...