Endocrine Abstracts

Introduction: The only curative treatment of primary hyperparathyroidism (pHPT) is surgery. Accurate pre-operative localization of abnormal parathyroid glands is an essential prerequisite to reduce the complication risk associated with surgery. We aimed to determine the diagnostic value of jugular venous sampling (JVS) in cases of pHPT in which the location of parathyroid adenomas could not be determined through various preoperative imaging studies.Metho...

Introduction: Primary hyperparathyroidism (pHPT) is the third most frequently seen endocrine disease with autonomous overproduction of parathyroid hormone (PTH) in one or more parathyroid glands. It’s associated with osteoporosis, bone fractures, nephrolithiasis, renal failure and increased cardiovascular risk. We aimed to investigate the distribution of the clinical manifestations and biochemical features in patients with pHPT.Methods: A retrospect...

Objective: To document clinical and laboratory presentations of FSH-staining pituitary adenomas, and to compare pure FSH-staining adenomas with mixed FSH and other anterior pituitary hormones staining ones.Methods: We analysed our inpatient records for patients who underwent pituitary surgery, and analysed histopathological reports for FSH-staining pituitary adenomas. Immunostaining positivity was defined as immunostaining of ≥5% of the adenoma cel...

Ectopic secretion of corticotropin(ACTH) by nonpituitary tumors accounts for 10–15% of ACTH dependent Cushing’s syndrome (CS). Generally it is difficult to localize the ACTH secreting tumor by conventional imaging methods because these tumors are often small in size. Here we present a case of ectopic ACTH syndrome diagnosed with octreotide scan.Case: A 26-year-old male patient presented with moon face, purplish striae, supraclavicular fat pads ...

Introduction: Our aim is to investigate whether ovarian reserve is decreased in patients with euthyroid Hashimoto’s thyroiditis (HT).Method: Our study included 110 euthyroid HT patients and 72 age matched healthy women (controls; C). In all patients FSH, LH E2, and P levels were measured from blood samples, and ovarian volumes (OV) and antral follicule count (AFC) were measured using ultrasonography at 3rd day of menstruation....

Brown tumor is a non-neoplastic lesion which resulting from abnormal bone metabolism caused by hyperparathyroidism. We report a rare case of peripheral brown tumor related with primary hyperparathyroidism which simulating a peripheral giant cell granuloma of the jaws.Introduction: PHPT occurs in a setting of excessive parathyroid hormone (PTH) secretion which resulting in hypercalcemia.Case report: A 50-year-old man was admitted to...

When follicular thyroid carcinoma (FTC) is diagnosed, 25% of the patients extrathyroidal invasion, 5–10% lymphatic metastasis and 10–20% distant metastasis are determined. The most common site of distant metastases of FTC is the lung, followed by the bone. The incidence of skull metastasis of FTC is about 2.5–5.8%. Skull metastasis of FTC was located in the skull base and occipital area.Case: A 60-year-old man admitted at 2006. He was oper...

BackgroundMucormycosis is an opportunistic fungal infection that can be aggressive and mortal. Diabetic ketoacidosis(DKA) is a risk factor for mucormycosis. We present a case with mucormycosis presenting with newly diagnosed diabetes mellitus and DKA.Case presentationA 34-year-old male patient presented with confusion and vomiting. He had no comorbiditiy. On admission the patient was afebrile, hypotensive (85...

Introduction: Acromegaly is a rare pathological condition characterized by excessive growth hormone (GH) secretion, leading to elevated levels of insulin-like growth factor 1 (IGF-1). According to the 2022 World Health Organization classification, GH-secreting pituitary adenomas fall under the PIT1-lineage. Pure GH-secreting adenomas selectively release growth hormone and may exhibit dense or sparse granulation patterns. Other subtypes include mammosomatotroph adenomas, mature...

Introduction: Adverse pregnancy outcomes have been associated with maternal thyroid dysfunction. However, optimizing the best threshold value to improve maternal and perinatal outcomes and alleviate complications by establishing population-based gestation-specific reference intervals (RIs) instead of using recommended universal cut-off values, especially for thyroid-stimulating hormone (TSH), is still an ongoing debate. The aim of this study was to compare the prevalence and r...