Endocrine Abstracts

Introduction: Cryptorchidism is unilateral or bilateral absence of the testes from the scrotum. One of the differential diagnosis is congenital bilateral anorchia. Vanishing testes syndrome is associated with low serum AMH concentrations and an absent or subnormal response to stimulation with hCG. We report the case of a 22-year-old boy diagnosted with bilateral cryptorchidism and hypergonadotropic hypogonadism at the age of 17 years old. At the time of diagnosis the scrotum w...

Background: The rapid advancements in the field of allogenic hematopoietic stem cell transplantation (allo-HSCT) and better management of acute postprocedural complications have led to increased life expectancy, but at the same time to higher incidences of long-term complications. Conditioning regimens (chemotherapy, total body irradiation), immunosuppresive treatments and immune dysregulation threaten endocrine and metabolic functions, leading to late effects, including hypog...

Background: Childhood acute lymphoblastic leukemia (ALL) is no longer a death sentence. With survival rates approaching 90%, focus needs to shift towards improving long-term quality of life. Compared to the general population, adult survivors have four-fold excess risk of mortality secondary to cardiovascular diseases. Thus, modifiable risk factors, such as altered glucose metabolism, are of great importance and should be actively sought after. Studies show high prevalences of...

Congenital fibrous dysplasia is a rare disease with a broad spectrum of manifestations, including various endocrinopathies;precocious puberty, hyperthyroidism, excess growth hormone, hypophosphatemia mediated by FGF23.We present the case of a 33 year old male, who presented in our endocrinology service with infertility and bone pain. He was diagnosed at the age of years old with congenital fibrous dyplasia and suffered multiple surgeries for bone decompr...

Studies evaluated bone involvement in the metabolic control of fat cells. It has been reported that osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release adiponectin, which increases sensitivity to insulin.The aim: Of the study was to evaluate osteocalcin levels in subjects with metabolic syndrome compared with age and sex matched control groups.<p cl...

Objectives: Metabolic syndrome, especially obesity and diabetes are associated and responsible for a depressive psychological status. Meanwhile, antidepressors are responsible for metabolic disturbances, such as insulin resistance. The study aims to determine predictive factors of response to antidepressant pharmacotherapy in patients with metabolic syndrome.Materials and methods: A retrospective study conducted in Institute Parhon’s Department for ...

Objective: CT findings indicating that a patient is at risk for developing optic neuropathy are worth- while observations.Aim: The aim of our study was to determine the utility of CT imaging in identifying patients at risk for optic neuropathy and to compare quantifiable nonvolumetric CT data from a large series of orbits with Graves ophthalmopathy.Method: A total of 226 patients (452 orbits), 175 women (350 orbits) and 51 men (102...

Introduction: Midnight salivary cortisol measurement (MSC) has been recently introduced as a diagnostic test for hypercortisolism. The aim of our study was to compare the diagnostic value of two methods of screening for Cushnig’s syndrome (CS): MSC and 24-h urinary free cortisol (UFC), wildely accepted as a ‘gold standard’ for this diagnosis.Patients and methods: Three groups were studied: 30 patients with CS (mean age±S.D.</sm...

Introduction: Primary hyperparathyroidism is typically caused by a parathyroid adenoma (80-85% of the cases). Very rare causes are represented by parathyroid carcinoma and atypical parathyroid adenoma (0.5-1.5% of the cases). Atypical parathyroid adenomas have atypical histological features, not sufficient to be considered a carcinoma, and have an uncertain malignant potential and risk of recurrence. We report the case of a 66-year-old man referred from another medical center ...

Multiple endocrine neoplasia (MEN) is characterized by the occurrence of tumors involving two or more endocrine glands; MEN 2 is defined by medullary thyroid carcinoma in association with phaeochromocytoma and appears in several clinical variants, which may be inherited as autosomal dominant syndromes. Mutational analysis of RET protooncogene has been use in the diagnosis and management of patients and families with MEN 2 variants.Aim: In this study, we ...