Endocrine Abstracts

Objective: Distant metastases from papillary thyroid carcinoma (PTC) are relatively rare and may be associated with a poor prognosis. Herein, we describe a case report with adrenal and lung metastasis of follicular variant of PTC in the context of the review of the literature.Case Report: A 52-year-old male presented with complaints of swelling of his neck and cough. He had been diagnosed with multinodular goiter, obesity, pre-diabetes, and hypogonadism....

Objective: C-reactive protein (CRP) is a nontraditional risk factor that predicts cardiovascular disease but its relationship between diabetes and insulin resistance is not well documented. We evaluated the association of CRP levels and insulin resistance in a group of patients at high risk for diabetes.Materials and methods: In this study we evaluated 22 first degree relatives of type 2 diabetic patients with impaired glucose tolerance test (Group 1) an...

Background: The association between diabetes and dementia has been well documented (1, 2, 3) and with Australia’s aging population, the already significant disease burden of both pathologies will inevitably progress over time. Despite both being progressive pathologies which escalate over time, there have not been any studies pertaining to degree of glycaemic control and the extent to which this relates to prevalence of dementia.Aims: To determine a...

BackgroundThe reported HMBS mutations of acute intermittent porphyria(AIP) have been increasing gradually in China. We aim to explore its mutation characteristic in China and improve the understanding of its molecular heterogeneity.Material/methodsWe searched the literature about Chinese AIP patients with HMBS mutation in the PubMed, CNKI, Wanfang and CQVIP database, and 3 AIP patients with HMBS mutation in o...

Aim: In our study, in regard with the women cases of obesity, we have aimed at determining the correlation that existed among the anemia markers, insulin resistance (IR) and fact of Metabolic syndrome (MetS).Method: We have conducted our assessment 67 women who had resorted to our clinic due to their obesity complaints and were in the premenopausal and mean age 36.7±8.8 years. We have put forward the demographic data and measured the biochemical (fa...

Aim: Hypoadiponectinemia is known to be associated with insulin resistance, diabetes and obesity. Since gestational diabetes is together with increased body mass index (BMI) and decreased insulin sensitivity, the evaluation of adiponectin levels in these patients is interesting. We investigated the relationship between adiponectin and glucose tolerance during pregnancy and after delivery.Materials and methods: We evaluated plasma adiponectin levels, insu...

Purpose: To investigate the effects of Tribulus terrestris (TT) on immune function in over-trained rats and explore the mechanisms – the role of glucocorticoid (GC) and glucocorticoid receptor (GR).Methods: Thirty male SD rats were randomly divided into control group, over-trained group and over-trained+TT group. The last two groups were trained on a motor-driven treadmill with a progressively increased load for 6 weeks. The over-trained+TT...

Aim: Comparison of the parameters of obesity with the newly-defined adipocytokines in females applying to our clinic for obesity.Method: Demographical data of 36 obese females were determined. Cases were classified as obese and morbid obese according to BMI values. Biochemical parameters were measured for all the cases. Thicknesses of subcutaneous and visceral fatty tissues were measured on ultrasonography. Statistical significances were evaluated by app...

Context: Transcriptomic based characterization of signaling pathways in the adrenals of different subtypes of Cushing’s syndrome.Patients: For preliminary NGS analyses, a total of 27 adrenal samples were used. The cohort consisted of the following patient groups: Cortisol producing adenoma (CPA, n=9), primary bilateral macronodular adrenal hyperplasia (PBMAH, n=10). The adjacent normal adrenal tissue from pheochromocytoma patients ...

Personalized medicine is a crucial part of modern medicine. As a result, other therapeutic options apart from levothyroxine are considered when treating hypothyroidism. Desiccated thyroid pharmaceuticals, that in addition to thyroxine (T4), contain triiodothyronine (T3), are one of them. ETA recognized the rapid use of desiccated thyroid pharmaceuticals and described specific guidelines for its utilization. The biggest problem of their use is unresolved issues of content that ...