Endocrine Abstracts

Objectives: The TNM classification is a worldwide benchmark for reporting the extent of malignant disease and is intended as a prognostic tool to predict the outcome in patients with cancer. Until 2004, no TNM classification was available for adrenocortical carcinoma (ACC) and different staging systems were used. Due to the rarity of this malignancy, the prognostic value of different staging systems has never been compared directly in a large series of patients.<p class="a...

ImportanceThere remains uncertainty about the impact of menopausal hormone therapy (MHT) on women’s health. A systematic, comprehensive assessment of the effects on multiple outcomes is lacking.ObjectiveTo comprehensively summarize evidence on the benefits and harms of MHT across diverse health outcomes in women.Data sourcesMEDLINE, EMBASE and 10 other databa...

A 52-year-old man was referred in June 2009 with weakness, unsteadiness, diarrhoea and weight loss of 14 kg in the last 4 months. His past medical history included hypertension, ischaemic heart disease and chronic obstructive pulmonary disease. He was a heavy smoker and admitted to drinking heavily for the past 9 months. His serum sodium was 126 mmol/l, serum potassium 2.0 mmol/l, serum bicarbonate 31 mmol/l. His chest X-ray was normal. He had had persistent hypokalaemia for 4...

Background: Thyroid cancer is the most common endocrine malignancy, and papillary thyroid carcinoma (PTC) is the most frequent type of thyroid malignancy. Although the mortality rate is low, some patients experience cancer recurrence during follow-up periods. Early detection of recurrence helps improve the outcomes of patients and reduce the socioeconomic burden. In this study, we investigated the accuracy of a novel multi-modal prediction model by simultaneously analyzing num...

Objective: Randomized trials demonstrated a lower risk of cardiovascular (CV) events with sodium – glucose cotransporter-2 inhibitors (SGLT-2i) in patients with type 2 diabetes(T2D) at high CV risk. SGLT2-i should be considered as a valuable therapy in T2D with established atherosclerotic cardiovascular disease (ASCVD) or heart failure (HF). We analyzed the effects of cardiovascular function of SGLT 2 inhibitors in T2D with ASCVD or HF compared with dipeptidyl peptidase-4...

Objective: Dapagliflozin, sodium-glucose cotransporter-2 (SGLT-2) inhibitor, reduces hyperglycemia and body weight by inhibiting renal glucose reabsorption. However, only a few studies have shown the efficacy of dapagliflozin in type 2 diabetic patients. We evaluated the efficacy and safety of body weight reduction of dapagliflozin in real practice with type 2 diabetes in Korea.Methods: This is a retrospective, observational study, data from 61 patients ...

Objective: This study was performed to determine the impact on quality of life and sleep impairment of painful diabetic peripheral neuropathy (PDPN).Research design and method: The study pool consisted of 200 randomly selected peoples with type 2 diabetic peripheral neuropathy. PDPN was diagnosed using visual analogue scales (VAS) and medical history. The patients were asked to answer the Brief Pain Inventory-Short Form (BPI-SF), Medical Outcomes Study S...

Introduction: Occurrence of follicular thyroid carcinoma (FTC) is limited almost within thyroid gland, but distant metastasis is discovered uncommonly as first presentation. We experienced a rare case about recurrent bone metastasis of FTC with unknown primary site.Case report: A 58-year-old woman complained about back pain for 3 years. A 5 cm sized mass in right 8th posterior rib was discovered and performed resection. The result of pathology was bone m...

Objective: Dapagliflozin, sodium-glucose cotransporter-2 (SGLT-2) inhibitor, reduces hyperglycemia and body weight by inhibiting renal glucose reabsorption. However, only a few studies have shown the glycemic efficacy on a combination of dapagliflozin in type 2 diabetic patients in Korean. We evaluated the efficacy and safety of glucose control on a combination of dapagliflozin in people with type 2 diabetes in Korea.Methods: This is a retrospective, obs...

Current guidelines on cardiovascular (CV) disease prevention recommend targeted management after assessment of CV risks using many of available method even if the patient is asymptomatic. This study was performed to explore how CV high-risk is differently detected between two distinct methods: non-invasive test (NIT) and risk calculation and how the awareness of CV high-risk impacts physician and patient behavior for risk management in diabetes patient.A...