Endocrine Abstracts

Adrenocortical carcinomas (ACC) are rare and usually very aggressive tumors with heterogeneous outcomes. The individual variability in tumor progression and patients’ survival is linked to ACC biology and molecular heterogeneity, reinforcing the need to identify markers with prognosis value, to allow an accurate clinical strategy. Currently, in the absence of specific molecular markers, ACC prognosis is mainly predicted by the European Network for the Study of Adrenal Tum...

Most of adrenocortical tumors (ACT) are benign and non-functioning tumors, in contrast to adrenocortical carcinomas (ACC), which are rare and usually very aggressive tumors with a poor prognosis. The pathological discrimination between adrenocortical adenomas (ACA) and ACC is mainly based on unspecific and subjective histological features, resulting in inaccurate diagnosis in several cases. Numerous studies have previously described the potential value of immunohistochemistry ...

Introduction: Insulinomas are the most frequent cause of endogenous hypoglycaemia. 90 to 95% of these are benign. Surgical enucleation or resection is the standard treatment. Medical therapy focuses mainly on the use of diazoxide with few alternatives in patients with high surgical risk.Case-report: Female patient, 89 years-old, non-diabetic, with previous history of acute myocardial infarction, stroke with motor sequelae, pacemaker carrier and severe ao...

Introduction: The diagnosis of infected ulcer is mainly clinical. The goals of the microbiological studies are identification of the pathogen and evaluation of susceptibility to antibiotics to minimize exposure to drugs and selection of resistant strains.Methods: Retrospective cohort study; Data collection: 1 January 2010 to 31 December 2014. Were included wound samples of aspirate, nonsurgical/surgical exudate, pus from abscesses and bone fragments from...

Introduction: The complications related to ulcerated foot lesions are a common cause of hospitalization among diabetics. Diabetic foot infection is associated with high morbidity and is the most common precipitating factor to precede amputations of the lower limbs.Methods: Retrospective, cohort study; were included 200 patients from the Diabetic Foot consultation of the Endocrinology Department between 1 January and 31 August 2015. Ulcerated lesions were...

Introduction: Type 1 Diabetes (DM1) is associated with a destructive autoimmune process of pancreatic b-cells. The presence of anti-islet cells (ICA) antibodies (Ab), as well as for distinctive antigens – GAD65, IA2 or Insulin (IAA) - is related to the disease development.Aim: To evaluate the effect of DM1 antibodies on the measures of glycemic variability (GV) obtain through continuous glucose monitoring (CGM).Materials and m...

Introduction: Pheochromocytoma (Pheo) and paragangliomas (PGL) are rare catecholamine-producing tumors.Near 35% of patients have disease-causing germline mutations.10% are malignant although the malignancy rate differs accordingly to the genetic background.Purpose: This study aims to characterize the sample of patients followed on a tertiary Portuguese Center and associate the presence of genetic mutation with clinical presentation.<p class="abstext"...

-Diana Borges Duarte and Francisca Puga are joint first authors and contributed equallyBackground: As therapeutic options improve for Cushing’s disease (CD), most patients can now achieve control or cure of hypercortisolism. However, persistent complaints are often reported. Evaluation of health-related quality of life (HR-QoL) can highlight impairments beyond the stricter clinical aspects. Our aim was to evaluate HR-QoL with a specific focus on men...

Introduction: Obesity is associated with the low consumption of fruit and vegetables.Objective: Evaluate the obesity and the fruit and vegetables consumptions in children after an intervention of school food education program.Methodology: It was implemented a food education program in three classes (n=55) of 1st cycle, on school year (2016/2017) and the evaluation of this action was done comparing fruit and vegetables cons...

Introduction: A large proportion of the Portuguese population has overweight and the process of weight loss is often focused solely on weight. However, it is essential that there is a good evolution of the body composition, namely in the decrease of fat.Objective: Evaluate the anthropometric and body composition evolution in a group of individuals followed for a weight loss.Methodology: This sample consisted of 30 adult and who wer...