Endocrine Abstracts

Background: Preeclampsia (PE) is a multifactorial and multisystem disorder, with unknown pathophysiology, but factors such as defective trophoblast invasion and narrowing of spiral arteries may be contributing to the onset of PE and affecting mother and foetus development. Early prediction of PE may improve the surveillance and prognosis of hypertension in pregnant women in preventing associated complications. Therefore, it is essential to find markers for the detection of PE ...

Objective: Papillary thyroid carcinoma (PTC) is themalignantcancer with altered microRNA (miR) changes. miR149-5p and miR-548c-3p participates in multiple processes of tumor development, progression, tumor suppression. Whereas miR-3619-3p plays role to promote cell migration and invasion in PTC. However, the role of miR149, miR-548c-3p, and miR-3619-3p in PTC and the underlying mechanisms remain undefined. Therefore, the present study is aimed to quantify therelative expressio...

Central obesity is strongly associated with insulin resistance and chronic sub-clinical inflammation, which is implicated in the development of type 2 diabetes (T2DM). However, the mechanisms underlying this link remain unclear. Recently JNK, a mitogen activated protein kinase (MAPK), has been implicated in obesity and insulin resistance by interfering with insulin action. Studies in rodent models show that phosphorylated JNK-1 is elevated in obesity, whilst the absence of JNK...

Background: Follicular differentiated thyroid cancer (FDTC) is the most common endocrine cancer, globally. Next-generation sequencing (NGS) in thyroid cancer allows for high-throughput genetic sequencing in short time. This analysis offers useful information on tumor biology. NGS Studies on follicular differentiated thyroid cancer are scanty from South East Asia. In this context, we set out study the pattern of a genetic panel wide somatic mutations in thyroid cancer.<p cl...

Background: Follicular differentiated thyroid cancer (FDTC) is the most common endocrine cancer, globally. Next-generation sequencing (NGS) in thyroid cancer allows for high-throughput genetic sequencing with quick turnover. NGS Studies on papillary thyroid cancer are scanty from South East Asia. In this context, we conducted this study of a genetic panel wide somatic mutations in thyroid cancer.Methods: We selected 21 FDTC cases. All of them underwent t...

Background: Diabetes mellitus (DM) is the commonest endocrinopathy, Worldwide. Amongst the protean complex genetic variations, cubulin gene and megalin gene mutations in diabetes are important in dictating genotype-phenotypic correlations and natural clinical course of diabetes. The genetic studies in this area are especially very sparse from Indian sub-continent. In this context, we analyzed the prevalence of cubulin (CBN) and megalin (LRP2) gene mutations, as part of NGS (Ne...

Background: Preeclampsia (PE) continues tochallenge both the clinicians and researchers worldwide, as the existing knowledge on its etiopathology does not come up with an efficient and foolproof treatment regime due its progressive nature and uncertain diagnosis and prognosis. In this context, miRNAs represent a potential therapeutic target and a diagnostic tool.Objectives: Circulating microRNAs present in maternal blood play an important role in the eti...

Introduction: Papillary thyroid carcinoma (PTC) is the most frequent endocrine malignancy. Apart from genetics, autoimmunity has been implicated in its pathogenesis. In this context, we set out study the role of Pro- inflammatory cytokines in PTC in South Indian population.Material and methods: This prospective case-control study was conducted on surgically managed PTC patients. Institutional ethical committee approval was obtained. Diagnosis of PTC was ...

Introduction: Thyroidectomy can performed by open or wide array of endoscopic techniques. Lack of uniform consensus on specific indications for each technique leads to confusion on ideal thyroidectomy technique. In this context, we analysed our experience with specific emphasis on deducing an algorithm on ideal technique for a given patient. Material and methods: This is a retrospective study conducted at a tertiary care endocrine surgery department in S...

Background: Thyroid cancers represent a diverse group of malignancies characterized by intricate genomic landscapes, necessitating advanced molecular investigations for a comprehensive understanding of their underlying genetic alterations. This study harnesses the power of Whole Exome Next-Generation Sequencing (WES) to unravel pan-exomic mutations in thyroid cancer samples. The primary objectives include correlating genomic changes with clinicopathologic features and unravell...