Endocrine Abstracts

Purpose: Papillary thyroid cancer (PTC) has a strong propensity for lymph node metastasis, which is related with local recurrence, and disease-specific survival in the elderly. We evaluated the association between lymph node metastasis and disease multifocality, bilaterality, and other clinicopathological variables to identify risk factors and aid surgical decision-making. The relationship between the number of foci and metastasis to cervical lymph node was also evaluated....

Background: We evaluated the impact of the multifocality on post-lobectomy recurrence in patients with differentiated thyroid cancer (DTC).Methods: We analyzed 1,684 patients with DTC who underwent thyroid lobectomy from 2008 to 2015 using logistic regression models to calculate the relative risk on post-lobectomy recurrence.Results: Tumor diameter increased from 4.9 mm to 8.1 mm and the proportion of extrathyroidal extension (ETE)...

Objective: Cilostazol, a selective inhibitor of phosphodiesterase 3, which has been widely used in patients with atherosclerotic diseases, is known to have additional beneficial effects on dyslipidemia. ATP-binding cassette transporter A1 (ABCA1) plays a critical role in the regulation of intracellular cholesterol levels in hepatocytes. We aimed to investigate the effect of Cilostazol on hepatic steatosis and its underlying mechanism related to ABCA1.Met...

Objective: Obesity is a well-known risk factor for type 2 diabetes, but few data exist on the association between weight changes and future diabetes risk in non-obese subjects. This study aimed to investigate the effect of weight changes on the incidence of type 2 diabetes in Korea, using prospective nationwide data.Research design and methods: A total of 51 405 non-diabetic subjects were included who had undergone health examinations in 2002 and complet...

Background: Targeted therapy using phosphatidylinositol 3-kinase (PI3K) inhibitors has become widespread in the treatment of cancers. Although PI3K inhibitors raised concern about the alteration of glucose and lipid metabolism from animal studies, human clinical data have been rarely reported.Aim: We investigated the clinical manifestations, incidence of diabetes and its predictive factors in cancer patients who treated with PI3K inhibitors.<p class=...

Introduction: Frimley Park Hospital, Surrey had been a negative HbA1c outlier for 3 consecutive years. The Children’s and Young People’s (CYP) diabetes team embarked upon the RCPCH National CYP Diabetes Quality Improvement (QI) Programme in November 2019. There was little qualitative data on ward nurse education, however, experience revealed engagement in staff training was the main barrier. Although regular education sessions were available to ward staff, attendance...

Ken K Y Ho, University of New South Wales, Sydney, Australia AbstractKen Ho is a professor of Medicine at the University of New South Wales and is the Head, Pituitary Research Unit, Garvan Institute of Medical Research and Chairman, Department of Endocrinology, St. Vincent's Hospital, Sydney.He graduated in medicine at the University of Sydney in 1975, undertook research studies towards a Doctora...

Nonylphenol (NP), a member of alkylphenol family, has been widely used in both industry and household. NP is classified as an endocrine-disrupting chemical and is known to act as an agonist of the GPER (GPR30). The aim of this study was to address the two-generational effects of para-nonylphenol (NP) on the body weights, reproductive organ weights and histopathologies of ICR mice. We also test the potential reproductive toxicity of octylglucuronide (OG), a substitute candidate...

Introduction: Calbindin-D9k (CaBP-9k), which is a calcium ion buffering and transporter gene, is known to be regulated by the vitamin D and steroid hormones, and is mainly expressed in mammalian intestine, kidney and uterus. However, CaBP-9k expression in lung has not been studied. Maintaining lung structure using pulmonary surfactant is important for pulmonary gas exchange. Steroids are known to accelerate maturation of the fetal lung and secretion of surfactant. Otherwise th...

Introduction: Type 2 diabetes has a relationship with fatty liver. Fatty liver can progress to liver fibrosis. This study examined relationship between liver fibrosis and diabetes-related complications in type 2 diabetic patients.Methods: This study analyzed data from the 2007 to 2015 the Korea National Health and Nutrition Examination Survey (KNHANES) in South Korea. Which included values of c-peptide, fasting blood sugar, AST, ALT, and platelet to calc...