Endocrine Abstracts

Introduction: Hemochromatosis is an iron storage disease characterized by iron deposition in parenchymal cells due to increased intestinal iron absorption. Iron overload leads to tissue damage and dysfunction particularly in the liver, pancreas, heart, joints, and pituitary gland. Panhypopituitarism is a clinical condition in which the anterior pituitary gland hormones are deficient. Herein we report a very rare case of panhypopituitarism due to hemochromatosis.<p class="a...

Aim: The present study was designed to examine the relationship between adiponectin gene (T45G in exon 2) polymorphism and clinical and hormonal characteristics in women with polycystic ovary syndrome (PCOS).Materials and methods: Ninety-six patients with PCOS and 93 healthy subjects were included in the study. Serum levels of sex steroids, insulin and adiponectin levels were measured. Insulin resistance was evaluated by homeostasis model assessment (HOM...

Context: HIF-1α is frequently upregulated in many tumour types and has been shown to be critical for radio- and chemosensitivity in pre-clinical studies. However the regulation and function of HIF-1α is unknown in thyroid carcinomas.Objectives: Here, we evaluated basal expression and regulation of HIF-1α and target genes in primary thyroid carcinomas and in thyroid cancer cell lines (NPA, FTC-133, ARO).Design and out...

Introduction: In recent years, interferon (IFN) is used in treatment of chronic hepatitis and the studies about the side effects of IFN therapy are increasing.Objective: We aimed to investigate the effects of IFN therapy on glucose metabolism.Materials and methods: Study group was consisted with 30 patients who were diagnosed as chronic hepatitis. Sixteen of 30 were chronic hepatitis B and 14 were chronic hepatitis C. Diagnose was ...

Introduction and aims: Mean platelet volume (MPV) is a newly indicator of platelet activation which was associated with atherosclerosis. There are limited studies in the literature about MPV levels in patients with both hypoparathyroidism and hyperparathyroidism. This preliminary study, we aimed to investigate a relationship with MPV and serum PTH and calcium levels in patients with disorder of calcium metabolism.Materials and methods: Fourty-nine hyperp...

Background: Isotretinoin has been used for many years to treat moderate or severe nodulocystic acne, disorders of sebaceous gland and keratinization and in the prevention of skin cancer. Certain types of retinoids may cause abnormalities in serum thyroid function tests by suppressing thyroid stimulating hormone (TSH). However, it is uncertain whether systemic isotretinoin has any effect on thyroid functions.Case: 18 years old woman has admitted to our ho...

Riedel thyroiditis (RT) is a rarest form of thyroiditis, and characterized by dense fibrosis of the throid gland and infiltration into surrounding tissues. RT generally presents with local symptoms association with compression and also fibrotic process can impact thyroid and parathyroid functions. We report a case with RT which presents with compression findings and also hypoparathyroidism and hypothyroidism. 30 year old women visited our outpatient clinic with a complaint of ...

Objective: The prevalence of incidentally discovered papillary thyroid microcarcinoma (iPTMC) has increased with the expanded use of diagnostic imaging, including nuclear medicine imaging techniques. While iPTMC appears to have a better prognosis than non-incidental PTMC, it was suggested that thyroid carcinomas that were incidentally discovered during 18F-fluorodeoxyglucose positron emission tomography/computer tomography (FDG PET/CT) or parathyroid scintigraphy may have poor...

Objective: Thyroid nodules are common in the population more than 90% are benign. Data about the long-term follow-up of benign nodular thyroid disease is limited. We aimed to clarify, clinical outcome, frequency and magnitude of volume changes in cytologically and/or sonographically benign nodules in long-term(> 5 years) follow-up and to determine the predictive features of nodule growth.Methods: We retrospectively collected data of cytologically and...

Expression of hormones other than GH may affect the prognosis in acromegalic patients. Generally, Ki-67 is a well-known proliferative index used to predict remission in pituitary adenomas. We aimed to evaluate the relationship of immunohistochemical expression pituitary hormones, ki-67 and remission. Also we evaluated the role of pre, post-operative clinical and laboratory values, pathological characteristics on long-term remission. We included 64 acromegaly patients that were...