Endocrine Abstracts

Introduction: Syndrome of Inappropriate Antidiuretic (SIAD) is the most frequent cause of hyponatremia in parenteral nutrition (PN) patients. Moreover, SIAD may be caused by multiple etiologies (drugs; pulmonary, neurological or abdominal disorders; malignant disease; idiopathic…). Our objective was to evaluate the main etiologies of SIAD in patients receiving PN.Methods: Prospective, non-interventional, multicenter study in 19 Spanish hospitals. F...

Introduction: Asymptomatic, mild or moderate elevations of creatine phosphokinase are frequently found in hypothyroidism, but rhabdomyolysis is rare, and even more so when it constitutes its clinical presentation.Clinical case: A 26-year-old male who regularly practiced sports, with no family or personal history of interest, went to the emergency room referring to myalgia, generalized cramps, and muscular weakness in the previous two weeks which had not ...

Non-functioning pituitary-adenomas (NFPAs) represent the most common pituitary tumor-type. To date, there are not clinical, biochemical, anatomo-pathological, immuno-histochemical or molecular parameters useful to predict their remission. Therefore, the aim of this study was to evaluate the potential relationship between the clinical, biochemical and pathological characteristics of patients with NFPAs, the expression profile of these tumours and the clinical outcomes during th...

Introduction: Hyponatremia is the most frequent electrolyte disorder found in clinical practice, and has been associated with increased morbimortalty. Hyponatremia is even more common among patients receiving parenteral nutricion(PN), a therapy increasingly in use. However, the morbimortality of hyponatremic patients on PN is unknown.Methods: Retrospective study, selecting all patients receiving PN in a teaching hospital from 01/11/11 to 01/06/12. We eva...

Introduction: Extended up to 20 years follow-up of several randomised control trials showed 34–43% diabetes risk reduction. Real life implementation studies performed worldwide in different settings and populations proved that also non-intensive, low budget lifestyle interventions can be effective. However little is known about long-term results of the translational studies.Objective: To study the risk factors changes of the DEPLAN non-intensive lif...

Introduction: In a majority of Spanish hospitals, serum sodium levels (SNa) are determined by indirect electrode methodology (sodium in the liquid fraction of serum) divided by the total serum volume (mmol/l). To avoid over/underestimating SNa, a formula can be applied: SNa corrected for total proteins (TP)=SNa×93 divided by (99.1−(0.7×TP)). Hypoproteinaemia is frequent in patients receiving parenteral nutrition (PN), and is probably related to surgery, acute d...

Background: It is disputable whether to repeat FNAB after the first one was nondiagnostic, or to submit the patient to operation.Methods: Indication for FNAB was a thyroid nodule of ≥1 cm or of a less size with clinical or ultrasound features of malignancy. In case of multinodular goiter each nodule was punctured and examined separately.3929 cases (8%) were noninformative out of 49 419 FNAB of thyroid nodules performed in Nor...

Background: Fine needle aspiration biopsy is generally acknowledged as a «gold standard» for diagnostics of thyroid malignancies. However, data on FNAB vary considerably in publications from different centers. In this study we have analyzed the results of more than 40 000 FNAB of thyroid nodules performed in North-West Regional Endocrine Center during 2010–2012 years.Subjects and methods: Indication for FNAB was a thyroid nodule of ≥...

Background: Unintented parathyroidectomy during thyroid surgery – is one of typical complications, especially when an operation is augmented by lymphodissection. In this work, we present the results of calcium metabolism analysis in such patients.Subjects and methods: 3929 operations of patients with different thyroid diseases were performed during 2010–2012 years. 82 inadvertently excised parathyroid glands were revealed at histological examin...

Introduction: Thyroid-associated ophthalmopathy is the most frequent extrathyroidal manifestation of Graves’ disease. Its treatment is based on the administration of intravenous corticosteroids, and the clinical activity score (CAS), TSH-binding inhibitor immunoglobulin (TBII) and TSH-receptor antibodies (TRAb) have been classically used to measure the response to treatment. However, in recent studies [1] it has been observed that other analytical parameters such as chol...