Searchable abstracts of presentations at key conferences in endocrinology

ea0086oc4.2 | Adrenal and Cardiovascular | SFEBES2022

Generation of novel tools for the study and development of targeted therapeutic approaches for pheochromocytoma and paraganglioma

Kemkem Yasmine , Santambrogio Alice , Montibus Bertille , Abascal Sherwell Sanchez Carlos , Willis Thea L. , Lodge Emily J. , Yianni Val , Oakey Rebecca J. , Andoniadou Cynthia L.

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours, which arise from neural crest (NC)-derived structures: the adrenal medulla and the paraganglia. Around one third of PPGLs are associated with inherited cancer susceptibility genes, the highest rate among all tumour types. Currently, the only diagnostic criterion for malignant disease is the presence of metastasis and no molecular or histological features have been identified that help predict risk. A...

ea0090p619 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Pancreatic autoimmunity in the diagnosis of type 1 diabetes: usefulness of zinc transporter 8 and proposal for stepwise assessment

Rodriguez Escobedo Raul , Gonzalez Martinez Silvia , Alonso Felgueroso Carlos , Morales Sanchez Paula , Diaz Naya Lucia , Delgado Elias , Luis Menendez Torre Edelmiro

Introduction: Zinc transporter 8 (ZnT8) autoimmunity has been established as one of the markers for the diagnosis of type 1 diabetes (T1D) along with glutamate decarboxylase (GAD) and tyrosine phosphatase IA-2 (IA-2) antibodies. The aim of this study is to understand the status of pancreatic autoimmunity in the diagnosis of T1D, with special attention to the usefulness of ZnT8. In addition, as a second objective, we study the proposal to perform the assessment of pancreatic au...

ea0090p178 | Reproductive and Developmental Endocrinology | ECE2023

Are there Differences Between Androgens When Studying Androgenisation in the Transgender Patient?

Latorre Mesa Carlos , Velasco de Cos Guillermo , Villar Bonet Aurelia , Moyano Martinez Ana , Alexandra Zapata Maldonado Gabriela , Ormazabal Monterrubio Maialen , Alio Lavin Gomez Bernardo , Teresa Garcia-Unzueta Maria

Introduction: In gender affirming therapy of the transgender male, increasing doses of testosterone are administered and as the androgen dose increases, various biochemical parameters such as haematocrit, creatinine and PSA increase. It is not known whether any parameters have advantages in monitoring this androgenisation. Our study evaluates the correlation between the increase in androstanediol glucuronide, testosterone, free testosterone and free androgen index (FAI) with t...

ea0090p255 | Thyroid | ECE2023

Two-year case series of a thyroid consultation at a hospital unit

Silva Maria Helena F. , Serejo Portugal Rita , Matos Goncalves Andre , Nagirnyak Volodymyr , Gabriel Oliveira Baltazar , Marques Carlos , Cabeleira Joana , Rita Sanches Ana , Cunha Martins Sonia , Sousa Carvalho Margarida

This paper aims to describe the followed population in the consultation, through a retrospective study in a hospital unit. This retrospective study was carried out during February 2020 to February 2022, and analyses the clinical processes of the patients that were followed in this consultation, and later analysing the data using Microsoft Excel® Over these two years, 395 patients were observed. These patients age average 61 years old, ranging from 17 to 93 years of age. M...

ea0090ep81 | Adrenal and Cardiovascular Endocrinology | ECE2023

Successful management of adrenal Cushing’s syndrome associated with androgen co-secreting adenoma during pregnancy: a case report

Rodriguez Arrieta Luis Antonio , Hoyos Valdelamar Juan Carlos , Restrepo Johnayro Gutierrez , Mejia Sanjuanelo Ana Milena , Rueda Galvis Myriam Vanessa , Corrales Santander Hugo Rafael

Introduction: Adrenal Cushing’s syndrome during pregnancy is rare, and few cases have been reported. It is infrequent to identify pregnant women with adenomas that have cortisol and androgen co-secretion. The diagnosis and treatment of excess cortisol during pregnancy is challenging when the patient does not want a pregnancy interruption.Case Report: 38-year-old woman with arterial hypertension for four years. During her working days, she remained u...

ea0090ep674 | Pituitary and Neuroendocrinology | ECE2023

Tolvaptan in the management of severe hyponatremia associated with acute intermittent porphyria

Gomez Carlos Garcia , Armengod Laura , Abad Ainhoa , Garcia Izquierdo Belen , Guzman Sanz Jorge , Rubio Ramos Miguel , Capristan Diaz Vanesa , Diez Fernandez Natalia , Palacios Nuria

Background: Acute intermittent porphyria (AIP) is an inherited autosomal dominant disorder characterized by hepatic deficiency of hydroxymethylbilane synthase (HMBS)/porphobilinogen deaminase (PBGD), the third enzyme of the heme synthesis pathway. Hyponatremia is one of the main presenting symptoms and it is thought to be related to an inadequate secretion of ADH (SIADH). Since AIP is an uncommon disease, there is little information about how AIP related hyponatremia responds ...

ea0063p266 | Pituitary and Neuroendocrinology 1 | ECE2019

Antitumor effects of growth hormone-releasing hormone (GHRH) antagonists in ACTH and GH-secreting pituitary adenoma cell lines

Fanciulli Alessandro , Gesmundo Iacopo , Gamba Giacomo , Castano Justo P , Luque Raul M , Alvarez Clara V , Dieguez Carlos , Chiara Zatelli Maria , Ghigo Ezio , Schally Andrew V , Granata Riccarda

Pituitary neuroendocrine tumors (PitNETs) are mostly benign lesions originating from the anterior pituitary and represent 10–15% of all the intracranial neoplasms. PitNETs can be classified in non-secretory, clinically non-functioning pituitary adenomas (NFPAs), and secretory, comprising prolactin (PRL), growth hormone (GH) and adrenocoticotropic hormone (ACTH) PitNETs. Surgical resection is the first line treatment for PitNETs, whereas chemotherapy and radiotherapy are p...

ea0063p269 | Pituitary and Neuroendocrinology 1 | ECE2019

Diabetes insipidus and diabetes mellitus type 2 diagnosed at the same time in a male with langerhans cell histiocytosis

Barcelo Carlos Antich , Soler Guillermo Serra , Font Mercedes Noval , Ribas Elena Mena , Povidano Santiago Tofe , Jimenez Inaki Arguelles , Fernandez Honorato Garcia , Macazaga Vicente Pereg

Introduction: Langerhans cell histiocytosis (LCH) is a rare systemic disease. Diabetes insipidus is the most frequent endocrine alteration and occurs mostly after diagnosis. Others are hypogonadism, growth hormone deficiency (GHD) and alterations in glucose metabolism.Clinical case: A 61-year-old smoker, diagnosed with LCH 9 years ago with pulmonary and hepatic involvement, without treatment, who consulted for asthenia, unquantifiable polyuria, polydipsi...

ea0049gp235 | Thyroid Cancer | ECE2017

Clinical Utility of response to therapy in combination with BRAF in risk assessment of thyroid cancer

Fernandez Laura Perez , De la Vieja Escolar Antonio , Zafon Carles , Galofre Juan Carlos , Riesco-Eizaguirre Garcilaso , Spanish Task Force for the study of BRAF SEEN Garcilaso

Response to therapy re-stratification approach has been recently included in the 2015 ATA guidelines as a risk-adapted approach to management of thyroid cancer. Our aim was to investigate the clinical utility of response to therapy variables obtained during early follow-up in combination with BRAF, a prominent oncogene in thyroid cancer with prognostic value. This was a retrospective multicenter study of 871 patients at 11 centers in Spain with papillary thyroid cancer followe...

ea0049ep100 | Adrenal medulla | ECE2017

Lung adenocarcinoma in a 34-year-old female SDHB asynptomatic mutation carrier – case report

Matos Maria Joao , Costa Claudia , Santos Ana Paula , Teixeira Manuel , Franco Carlos , Bento Joao , Azevedo Isabel , Dias Susana , Sampaio Ines Lucena , Cunha Ana Luisa , Torres Isabel

Introduction: Patients with germline mutations in one of the succinate dehydrogenase (SDH) genes are at substantially increased risk of developing paragangliomas (PGL) and pheochromocytomas (PCC). Mutations in SDHB are the most commonly found gene mutations in PC/PGL and are associated with younger ages at presentation, higher rates of metastases and poorer prognosis. Although familial PGL syndromes were initially thought to predispose only for PCC and PGL, other tumor types s...