Endocrine Abstracts

Objective: To evaluate the characteristics and glycemic control in admitted patients with type 2 diabetes and high vascular risk. To analyze therapeutic switch effect at hospital discharge on medium term metabolic control.Methods: Cross-sectional study including patients with type 2 diabetes and high vascular risk. Demographic and clinical characteristics, laboratory parameters, and diabetes treatment at baseline and discharge were analized. We used a sp...

The parallel increase in the amount of environmental contaminants and in the prevalence of some human diseases has led to a growing interest in understanding how these compounds, so-called endocrine disruptors, may affect human health. In this scenario, the concept that obesity is the result of the interplay of genetic and lifestyle factors has been changing due to the growing evidence that environmental contaminants might alter endocrine function.Organo...

Polycystic ovary syndrome (PCOS) is an important metabolic and reproductive disorder which confers substantially increased risk for type two diabetes and metabolic syndrome (MS). Our aim is to characterize the metabolic profile, insulin sensitivity (IS) and insulin secretion in control (Cw) and PCOS women (PCOSw) during different stages of reproductive life (S1: 18–35 years old, S2: 36–44 years old, S3: 45–55 years old). A total of 131 Cw and 129 PCOSw were incl...

Introduction: Radiation therapy is an effective treatment for relapsing or recurrent pituitary functioning adenomas, providing tumor volume control and hormone secretion normalization. However, there are several secondary effects to consider.Aims: To assess the efficacy of radiotherapy in the management of patients with acromegaly and Cushing’s disease (CD) treated in our Department, and the prevalence of radiation secondary effects.<p class="ab...

Introduction: Our group has a bank of human primary thyroid cultures (BANTTIC) obtained from patients. All are individual cultures specifically genotyped and phenotyped. We believe of great interest the search for biomarkers in these cultures using differential proteomic analysis.We have applied differential proteomics using 2D-PAGE coupled to MALDI-TOF-TOF-MS. We have compared benign pathologies (normal thyroid and Pendred’s syndrome) and different...

Introduction: Our aim was to determine the comparable value of thyroglobulin in the washout of lymph node fine-needle aspirate (FNATg) and fine-needle aspiration biopsy (FNAB).Materials and methods: We included 29 patients (37 FNAB) with history of differentiated thyroid cancer who underwent total thyroidectomy and were found to have suspicious cervical lymph nodes during follow-up. The referred population was evaluated on what concerns to gender, age, s...

Introduction: The association of autoimmune diseases in the same individual is common. It is well documented that Graves’ disease (GD) is associated to various autoimmune diseases, including: pernicious anemia, vitiligo, type 1 diabetes, Addison’s disease, systemic sclerosis, myasthenia gravis, Sjogren’s syndrome, rheumatoid arthritis and systemic lupus erythematosus. In addition, primary biliary cirrhosis (PBC) may be associated with rheumatoid arthritis, Sjogr...

Pituitary carcinoma is rare (0.1–0.2% of pituitary tumors), with a poor prognosis. It usually presents as invasive and secretory (ACTH or prolactin) macroadenoma. The diagnosis is confirmed by the presence of metastases. The latency period between the diagnosis of adenoma and carcinoma is variable (9.5 years for corticotrophinoma). The treatment includes surgery, radiotherapy and chemotherapy.We report a 58-year-old male, complaining of visual distu...

Introduction: High-resolution US and US FNA are techniques of great relevance in the evaluation of thyroid nodules. They are being used much more often by endocrinologists all over the world. In our Endocrinology Department, we started them in 2006; since then they have been progressively amplified. We present our results of US FNA performed from January 2007 until December 2009.Patients and methods: Two thousand eight hundred and seventy-seven FNA were ...

Introduction: Turner Syndrome (TS) is associated with cardiovascular anomalies and account for a threefold higher mortality in these women. The most common findings are congenital malformations of the heart (CMH), aortic dissection, valvular heart disease (VHD), hypertension and ischemic heart disease. It has been suggested that the ocurrence of cardiovascular disease in TS women is related to their karyotype and possibly to growth hormone (GH) treatment. Our study aimed to as...