Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep282 | Clinical case reports - Pituitary/Adrenal | ECE2016

Cyclic Cushing’s syndrome – a diagnostic challenge

Magalhaes Daniela , Bettencourt-Silva Rita , Queiros Joana , Freitas Paula , Vinha Eduardo , Pignatelli Duarte , Pereira Josue , Carvalho Davide

Introduction: The diagnosis of Cushing’s syndrome is often challenging considering that none of the used laboratory tests has an ideal diagnostic accuracy. The complexity of the diagnosis increases in cyclic disorder, which is characterized by repeated episodes of cortisol excess followed by periods of normal cortisol secretion.Case report: A 32-year-old woman with history of arterial hypertension and obesity presented with weight gain, hirsutism, a...

ea0041ep449 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Stress hyperglycemia ratio as a marker of disease severity in hospitalized patients with acute pyelonephritis

Sousa Santos Francisco , Fonseca Margarida , Paosinho Ana , Cruz Ines , Sequeira Duarte Joao , Gouveia Clotilde , Mello e Silva Alberto , Vasconcelos Carlos

Introduction: Hyperglycemia (irrespective of the presence of diabetes) has been associated with worse outcomes in hospitalized patients with a variety of diseases, namely critical illness. It is been recently proposed that a relative hyperglycemia – Stress Hyperglycemia Ratio (SHR) – might be even better associated with disease outcomes. We studied how SHR correlated with various morbidity parameters in hospitalized patients due to acute pyelonephritis.<p class="...

ea0041ep510 | Diabetes complications | ECE2016

Stroke recurrence (but not mortality) is higher among diabetic and prediabetic patients

Silva-Fernandez Julia , Garcia-Ruiz Rafael , Garcia-Ruiz Rosa M , Carmen Blanco-Valero M , Gonzalez-Pereira Carolina

Introduction: Diabetes Mellitus (DM) and prediabetic states (pre-DM) are well known risk factors for stroke. Admission blood glucose level and its control during hospital stay, help predicting arterial recanalization after thrombolysis and middle and long term prognosis. We analysed recurrence, mortality and nosocomial infectious complications in DM, pre-DM and patients without previous or newly diagnosed DM or pre-DM.Methods: Descriptive analysis in con...

ea0041ep533 | Diabetes complications | ECE2016

Diabetes and rhino-orbito-cerebral mucormycosis

Matta-Coelho Claudia , Silva Diana , Carvalho Sofia Daniela , Amorim Jose , Monteiro Ana Margarida , Souto Selma B , Marques Olinda

Introduction: Rhino-orbito-cerebral mucormycosis is a rare invasive fungal infection more common in diabetic and elderly patients. The presentation is acute, severe and rapidly progressive to disseminated infection. The diagnosis is done by the identification of risk factors, clinical and radiologic signs and tissue biopsy consistent with mucormycosis. The mortality rate is high, so timely diagnosis and intervention lead to better outcomes.Clinical case:...

ea0041ep555 | Diabetes therapy | ECE2016

Effects of GLP-1 analogues in the treatment of a population with DM2

Ivo Catarina , Nunes e Silva Joao , Simoes Helder , Lopes Luis , Passos Dolores , Marcelino Mafalda , de Castro Joao Jacome

The analogues of GLP-1(aGLP1) are a new class of anti-diabetic agents, administered subcutaneously for the treatment of Diabetes Mellitus type 2 (DM2). In the Portuguese market, there are two aGLP1 currently available: Liraglutide (once-daily administration) and Exenatide (once-weekly administration). They mimic the GLP-1, produced in the small intestine, stimulated by foods at this region, increasing the production of insulin, decreasing the satiety and slowing gastric emptyi...

ea0041ep634 | Endocrine tumours and neoplasia | ECE2016

Hypoglycaemia unawareness – a challenge in the management of a Von Hippel-Lindau patient

Bettencourt-Silva Rita , Souteiro Pedro , Magalhaes Daniela , Oliveira Joana , Bessa de Melo Renato , Costa Maia Jose , Carvalho Davide , Queiros Joana

Background: The key physiologic defences against hypoglycaemia are the decrease in insulin and the increased secretion of glucose counterregulatory hormones, namely glucagon and epinephrine. The absence of warning signs of impending neuroglycopenia is known as hypoglycaemic unawareness.Case report: Male, 26 year-old, without relevant medical history and with normal body mass index, presented with hypertension, palpitations and diaphoresis. Clinical suspi...

ea0041ep1150 | Thyroid cancer | ECE2016

Can we predict malignancy in AUS/FLUS by measuring TSH?

Marques Ricardo Rodrigues , Rafael Ana Alves , Santos Francisco Sousa , Silva Silvia Sofia , Duarte Joao Sequeira , Fernandes Luis Viana

Background: Fine-needle aspiration (FNA) is an important test for triaging patients with thyroid nodules and differentiating benign from malignant disease. According to Bethesda System Classification, the rate of AUS/FLUS is between 3–6% of all FNA. The malignancy risk is of 5–15%. TSH levels might be associated to the likelihood of malignancy in thyroid nodules according to some studies. Our aim was to establish a possible correlation between TSH level and malignanc...

ea0037ep113 | Steroids, development and paediatric endocrinology | ECE2015

Sarcopenia, more that dehydration, may be associate to underweight Portuguese centenarians

Silva Alda Pereira da , Matos Andreia , Valente Ana , Gil Angela , Alonso Isanete , Ribeiro Ricardo , Clara Gorjao , Bicho Manuel

Introduction: Fat-free mass has a functional significance in aging. The objective of this study was to evaluate the prevalence of underweight in a Portuguese population of centenarians and their relationship with dehydration or sarcopenia.Methods/design: Anthropometric data were obtained using standard procedures from 252 centenarians (100.26±1.99 years), 77.8% women (W). Body composition was assessed by tetrapolar bioimpedance. It was considered de...

ea0037ep737 | Pituitary: clinical | ECE2015

Clinical features of pituitary adenomas in elderly patients in Castilla La Mancha (Spain) compared with younger age group; a retrospective multicentre study

Vicente Almudena , Val Florentino Del , Cortes Claudia , Lamas Cristina , Aguirre Miguel , Silva Julia , Alramadan Moubarak , Quiroga Ivan

Background: Pituitary adenomas (PAs) in the elderly, defined as people older than 65 years, represent less than 10% of all PAs. Because of increasing life expectancy and improving health care, diagnosis PAs in this age group is increasing with time. Age-related changes and associated diseases may significantly modify the clinical presentation in these patients, delaying the diagnosis of PAs.Objective: To analyse the clinical features of PAs in elderly pa...

ea0037ep939 | Thyroid (non-cancer) | ECE2015

Seasonality in paediatric Graves' disease compared to the general population: impact of month of birth: a national study

da Silva Tiago Nunes , Pereira Bernardo Dias , Luiz Henrique Vara , Matos Ana Catarina , Cordeiro Maria Carlos , Raimundo Luisa , Portugal Jorge

Paediatric Graves’ disease (PGD) is an uncommon autoimmune disorder with a multifactorial origin. Although, in some autoimmune endocrinophaties the seasonality of month of birth (MOB) distribution differed from the general population, this association has not been study in PGD. The aim of this work was to analyse the impact of seasonality of MOB on PGD incidence in Portugal.In 2013, the Portuguese Paediatric Society of Diabetes and Endocrinology und...