Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1356 | Thyroid (non-cancer) | ECE2017

TSH receptor stimulating immunoglobulins – performance of an automated immunoassay

Tavares Patricia , Machado Catarina , Pedroso Jose Carlos , Vieira Joana , Rocha Gustavo , Monteiro Sara , Sousa Ana Margarida , Rodrigues Pedro , Lira Agostinho , Oliveira Maria Joao

Introduction: Graves’ disease (GD) hyperthyroidism is caused by autoantibodies against TSH receptor (TRAb). Three varieties of TRAb are now recognized: stimulating (TSI), blocking and neutral antibodies. Current TRAb immunoassays detect and quantify serum immunoglobulins that interact with the TSH receptor but without discriminating their function. An automated immunoassay for the detection and quantification of TSI is available.Objective: Our study...

ea0042p36 | (1) | Androgens2016

Androgen and Estrogen Receptor Co-regulation of Human UDP-glucuronosyltransferases 2B15 and 2B17 in Breast Cancer

Hu Dong Gui , Selth Luke , Tarulli Gerard , Meech Robyn , Wijayakumara Dhilushi , Chanawong Apichaya , Russell Roslin , Caldas Carlos , Robinson Jessica LL , Carroll Jason , Tilley Wayne , Mackenzie Peter , Hickey Theresa

Glucuronidation is an enzymatic process that terminally inactivates steroid hormones, including estrogens and androgens, thereby influencing carcinogenesis in hormone-dependent cancers. While estrogens drive breast carcinogenesis via the estrogen receptor alpha (ERα), androgens play a critical role as prohormones for estrogen biosynthesis and ligands for the androgen receptor (AR). Herein, the expression and regulation of two androgen inactivating UDP-glucuronosyltransfer...

ea0041oc7.1 | Cardiovascular endocrinology | ECE2016

Lipoprotein lipase DNA methylation: cause or consequence of metabolic disorders

Castellano-Castillo Daniel , Moreno-Indias Isabel , Queipo-Ortuno Maria Isabel , Fernandez-Garcia Jose Carlos , Alcaide-Torres Juan , Tinahones Francisco , Cardona-Diaz Fernando

Introduction: DNA methylation is one of the epigenetic mechanisms existing to regulate gene expression. It is believed that methylation of DNA is susceptible of change by environmental and nutritional factors. Thus, epigenetics provides a mechanism which may explain the etiology of some metabolic disorders and obesity.Aim: The aim of this study is to analyze the DNA methylation level of several lipoprotein lipase (LPL)-promoter-CpG island in human viscer...

ea0041oc14.4 | Thyroid Cancer | ECE2016

Prognostic value of microscopic extrathyroid extension in papillary thyroid carcinoma

Marques Bernardo , Martins Raquel , Couto Joana , Santos Jacinta , Martins Teresa , Mesquita Pedro , Gilde Patricia , Portela Ivan , Rovira Eugenia , Oliveira Sofia , Cruz Carlos , Neto Joao , Rodrigues Fernando

Introduction: Although recognized as a risk factor in most staging systems, including the UICC TNM classification, the significance of microscopic extrathyroid extension (ETE) in papillary thyroid carcinoma (PTC) remains controversial. Despite this fact, its diagnosis by a pathologist following surgery for tumours ≤ 4 cm without metastases means an upstaging to pT3 and stage III in patients over 45 years, implying a poorer survival. Our study aimed to evaluate the impact...

ea0041gp137 | Obesity | ECE2016

Adipose tissue infiltration in normal-weight subjects and its impact on metabolic function

Moreno-Indias Isabel , Oliva-Olivera Wilfredo , Castellano-Castillo Daniel , Lhamyani Said , Fernandez-Garcia Jose Carlos , Queipo-Ortuno Maria Isabel , Cardona-Diaz Fernando , Tinahones Francisco

Objectives: To study for the first time the differences in monocyte/macrophage infiltration, inflammation and adipogenesis in the subcutaneous and visceral adipose tissues of normal-weight subjects who differed in their degree of metabolic syndrome.Methods: The study included 92 normal-weight subjects who differed in their degree of metabolic syndrome. Anthropometric and biochemical parameters were measured. RNA from subcutaneous and visceral adipose tis...

ea0041ep425 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Patients with impaired fasting glucose exhibit a more frequent non-dipper or riser blood pressure pattern compared with normoglycemic patients

Fernandez-Garcia Jose Carlos , Cortes-Salazar Carmen Maria , de la Cruz-Troca Juan Jose , Garcia-Arnes Juan Antonio , Aranda-Lara Pedro

Objectives: To study blood pressure circadian pattern in patients with impaired fasting glucose (IFG) evaluated with ambulatory blood pressure monitoring (ABPM).Methods: Cross-sectional study evaluating patients taken from the Spanish ABPM Registry. Normoglycemia was defined as glucose <100 mg/dl and IFG as glucose 100–125 mg/dl. All patients underwent 24-h ABPM with a Spacelabs ambulatory blood pressure system. ABPM was performed according to s...

ea0041ep744 | Neuroendocrinology | ECE2016

Assessment of bilateral inferior petrosal sinus sampling in the differential diagnosis of the ACTH-Dependent cushing’s syndrome

Moreno-Moreno Paloma , Prior-Sanchez Inmaculada , Jimenez-Gomez Elvira , Padillo-Cuenca Jose Carlos , Delgado-Acosta Fernando , Oteros-Fernandez Rafael , Corpas-Jimenez Maria Sierra , Galvez-Moreno Maria Angeles

Objective: The aim of this study was to assess the diagnostic accuracy of BIPSS with desmopressin stimulation in the differential diagnosis of ACTH-dependent Cushing’s syndrome.Patients and methods: Retrospective study of patients studied to our hospital for diagnosis of ACTH-dependent Cushing’s syndrome (2000–2015). The histopathological results in patients who underwent a surgical procedure was considered the reference for statistical st...

ea0041ep783 | Obesity | ECE2016

Relationship between lipopolysaccharide levels and the gene expression profile in adipose tissue from morbidly obese patients

Clemente-Postigo Mercedes , Coin-Araguez Leticia , Oliva-Olivera Wilfredo , Alcaide-Torres Juan , Fernandez-Garcia Jose-Carlos , Cardona Fernando , Tinahones Francisco J

Introduction: Obesity is characterized by a low-grade inflammatory state which has been directly related to the development of insulin resistance and diabetes. Circulating lipopolysaccharides (LPS) have been proposed as a triggering factor for this inflammation. Likewise, adipose tissue (AT) capacity for lipid handling and storage is also a key factor for the development of obesity-related metabolic disorders. Animal studies have shown that LPS are able to modify the expressio...

ea0041ep792 | Obesity | ECE2016

Waist-to-hip ratio is the most discriminative parameter detecting OGTT alterations in men

Perez-Pevida Belen , Andrada Patricia , Llavero-Valero Maria , Gala Gutierrez-Buey , Jorge Nunez-Cordoba , Javier Gomez-Ambrosi , Camilo Silva , Juan Carlos Galofre , Javier Salvador , Gema Fruhbeck , Javier Escalada

Background: There is a clear relationship between obesity and carbohydrate metabolism alterations (CMA), such as impaired glucose tolerance (IGT) and T2D. OGTT is used for the diagnosis of those alterations, but is not performed in case of normal fasting glucose values (NFG). Moreover, BMI underestimates the diagnosis of obesity and body composition alteration can be crucial to the development of abnormal carbohydrate metabolism. This study aimed to examine the discriminating ...

ea0037gp.23.04 | Thyroid – diagnosis | ECE2015

Impact of antithrombotic and/or anticoagulant treatment in cytological results of thyroid fine-needle biopsy

Molina Carlos Arana , Cuadro Alberto Torres , Rivera Natividad Gonzalez , Garcia Clara Garcia , Jimenez Virginia Hernando , Ojeda Luna Florencio , Hernandez Tomas Martin

Introduction: Fine-needle aspiration biopsy (FNAB) of the thyroid gland is an accurate diagnostic test used routinely in the initial evaluation of nodular thyroid disease. A sizeable subset of patients are found to be taking antithrombotic and/or anticoagulant (AT/AC) medications. This creates a dilemma for the endocrinologist, who must weigh the risk of withholding these medications (and the associated potential benefit of diagnosis) against the perceived increased risk of ia...