Endocrine Abstracts

Objective: To document clinical and laboratory presentations of FSH-staining pituitary adenomas, and to compare pure FSH-staining adenomas with mixed FSH and other anterior pituitary hormones staining ones.Methods: We analysed our inpatient records for patients who underwent pituitary surgery, and analysed histopathological reports for FSH-staining pituitary adenomas. Immunostaining positivity was defined as immunostaining of ≥5% of the adenoma cel...

Background: NOD mice are the most frequently preferred animal models in type 1 diabetes (T1D) research. They develop spontaneous disease in 24 to 30 months. T1D can also chemically be induced in NOD mice for a faster disease progression. Two commonly used diabetes-inducing agents are Streptozotocin (STZ), which destructs pancreatic beta cells mainly through DNA fragmentation, and Cyclophosphamide (CY), which acts on suppressor T cells. TNF-Related Apoptosis-Inducing Ligand (TR...

While low testosterone levels are associated with higher incidence of type 2 diabetes mellitus in males. In contrast, hyperandrogenism is associated with higher risk of type 2 diabetes mellitus in females.We, therefore, have assessed alterations in beta-cell functions before and after testosterone replacement therapy in male patients with idiopathic hypogonadotropic hypogonadism (IHH) and before and after anti-androgen therapy in patients with polycystic...

Objective: Acromegaly is associated with increased morbidity and mortality, mostly due to cardiovascular complications. Thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with coagulation/fibrinolysis and inflammation. Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD). In this study, we aimed to evaluate the levels of TAFI antigen and also its relationship with other markers in a group of patients with acromegaly in compoa...

In this study we compared plasma adiponectin levels between patients with non-functional adrenal incidentaloma and subclinical Cushing’s syndrome. Our aims were to determine whether there was any difference of plasma adiponectin levels, any relation between cardiovasculer risk factors and to investigate the importance of adiponectin levels in subclinical Cushing’s syndrome patients according to non-functional adrenal incidentaloma patients. The patients referred from...

Objective: Our aim was to determine the prevalence and clinicopathological characteristics of thyroid cancers in the dialysis population and to evaluate potential risk factors.Design: We performed a retrospective analysis of our end-stage renal disease (ESRD) patients on dialysis and thyroidectomized patients without ESRD (2000–2006). Then we compared the data of thyroid cancer patients on dialysis (n=9) with the data of patients who had hist...

Objective: The thiazolidinediones are new and potentially useful developments in the treatment of type 2 diabetes and impaired glucose tolerance. We tested the effects of the thiazolidinedione, rosiglitazone on blood pressure in normotensive type 2 diabetes.Methods: After receiving approval from the local ethics committee, 25 normotensive diabetic patients were were enrolled to the study. Before the rosiglitazone treatment we measured plasma glucose, HbA...

Objective: Thiazolidinediones (TZDs) have become a powerful tool for lowering insulin resistance. The problem of cardiovascular adverse events including fluid retention and risk of heart failure, although of a low incidence, should be well known and recognized. We aimed to evaluate the effects of rosiglitazone treatment on cardiac function and show whether these effects are reversible when we continued this treatment.Methods: Fourty-six type 2 diabetic p...

Aim: The present study aimed to investigate the relationship of visceral fat accumulation with the existence of the carotid plaque in ischemic stroke patients.Materials and methods: Seventy patients (37 male, 33 female) with acute ischemic stroke were enrolled in the study. The carotid IMT and the existence of carotid plaque of the patients were evaluated by high resolution ultrasonography with a 7.5 MHz linear superficial array probe in B-mode. The abdo...

Background: Because type 1 diabetes (T1D) results from the T cell-mediated destruction of the insulin-producing pancreatic beta cells, the depletion of the autoreactive T cells via apoptosis represents a viable strategy for the prevention of autoimmune diabetes. The functional role TNF Related Apoptosis Inducing Ligand (TRAIL), a novel member of TNF superfamily, in autoimmune diabetes remains unknown. To understand this, TRAIL function was counteracted by an injection of solub...