Endocrine Abstracts

The four major hypertensive disorders in pregnancy are preeclampsia/eclampsia/HELLP syndrome, gestational hypertension, chronic hypertension and pre-eclampsia superimposed on chronic hypertension. The prevalence of hypertension in pregnancy has been reported to be around 6%. The commonest aetiology was found to be gestational hypertension which made up 40% of all cases. To our knowledge, secondary causes of hypertension in pregnancy has never been well described. We present a ...

Introduction: Thyroid isthmus has lack of normal parenchyma, and it connects both of thyroid lobes with lymphatic drainage. It is known that isthmic papillary thyroid cancer (PTC) presents frequent extrathyroidal extensions (ETE), multifocality and lymph node involvement. Therefore, many surgeons prefer total thyroidectomy and central compartment neck dissection (CCND) for the radical treatment of PTC located in thyroid isthmus. The purpose of this study is to figure out the c...

Background: Success of Graves’ orbitopathy (GO) immunosuppression treatment is highly variable; patients relapse and a debilitating residual disease burden often remains with current therapies. This study describes the outcomes of immunosuppression in a multi-ethnic GO cohort treated in accordance with pre-2021 European Group on GO (EUGOGO) guidelines with first-line intravenous-methylprednisolone (IVMP). This study aims: (1) To evaluate the effect of first-line and addit...

Introduction: Tc99m-Sestamibi+I-123 subtraction using planar and SPECT-CT (SPECT-CT 99mTc-MIBI parathyroid) is commonly used to investigate primary hyperparathyroidism (PHPT). We previously reported the sensitivity and positive predictive value of 4D CT parathyroid as the second line investigation in patients with non-diagnostic SPECT-CT 99mTc-MIBI parathyroid (https://www.endocrine-abstrac...

Hypertriglyceridemia (HTG) is known to be a risk factor for cardiovascular diseases, such as atherosclerosis and hypertension. Although the association between insulin resistance (IR) and HTG has long been recognized, the causal relationship between them has not been elucidated yet. Proper understanding of the effect of IR on HTG may better start with the realization that IR implies much more than mere impairment of glucose uptake in tissues. Given that the role of insulin is ...

Hemoglobin A1c (HbA1c) is formed from the addition of a glucose residue to the N terminus of the Beta chain of a hemoglobin molecule via a non-enzymatic glycation pathway. Its levels correlate with the ambient plasma glucose concentration. The 120-day life span of red blood cells makes HbA1c a useful tool to approximate the diabetic control of patients over three to four months. It has also been found to be an accurate predictor of the microvascular and macrovascular complicat...

Before releasing of SGLT-2 inhibitor, triple combination of metformin, DPP-4 inhibitor and TZD except sulfonylurea was commonly used in our center because it could be best option for delaying progression of diabetes by improving both insulin resistance and secretory dysfunction. SGLT-2 inhibitor is commonly used and recommended as initial combination with metformin in most guidelines because of cardiovascular risk and weight reduction, but theoretically add on to above combina...

Pasireotide long-acting release (LAR) is a multireceptor-targeted somatostatin receptor ligand approved for treatment of patients with acromegaly. In some clinical reports, pasireotide LAR has been shown to regulate biochemical outcomes more than other somatostatin receptor ligands. However, hyperglycemia was frequently observed in pasireotide LAR treated patients with acromegaly. Three patients were treated with pasireotide LAR to regulated biochemical parameters of acromegal...

The classical paradigm of lactotroph prolactin production and release is based around tonic inhibition by hypothalamic dopamine and stimulation by factors such as estrogen. We have recently shown that conditional ablation of pituitary androgen receptor (Foxg1-Cre ARKO) surprisingly does not change the concentration of circulating gonadotrophins but increases circulating prolactin in male mice; highlighting androgen signalling as a novel negative regulator of prolactin producti...

Background: Myocardial infarction is a common type of ischemic heart disease, which is the leading cause of disease-related death worldwide. In the ischemic heart, cardiac damage is initiated by a diminished blood supply, and swift restoration of blood supply is imperative to minimize cardiac injury. However, reperfusion itself can induce additional injury in the form of cardiac dysfunction, reperfusion arrhythmia, and by exacerbating myocardial infarction.<p class="abstex...