Endocrine Abstracts

Clinical case: A 51 year-old caucasian woman was admitted in the emergency room of our hospital with psicomotor agitation and confusion after four days of a profuse watery diarrhea, with 5 stools per day, abdominal cramps and vomiting. She started 500 mg of aspirin on her own initiative. Her medical profile included a type 2 diabetes treated with metformin 850 mg/12 hours and glyburide 7.5 mg/day, and hypertension treated with enalapril 20 mg/day. No renal imparement was docum...

Introduction: Macroprolactin (maPRL) is a high molecular weight variant of prolactin (PRL) which has reduced bioactivity. The purpose of the present study was to determine the clinic-analytical repercussion of the presence of maPRL in patients with hyperprolactinaemia.Patients and methods: A polyethylene glycol (PEG) precipitation test was used to detect the presence of maPRL in all consecutive samples with prolactin levels >50 ng/ml (1060 mUIL). A r...

The pituitary gland is the master gland of the endocrine system, controlling important physiological steps like growth, puberty or reproduction. There are different endocrine cell types within the adenopituitary, each one producing a specific hormone. Adaptation to different life stages and moments requires a plastic capacity based in proliferation and differentiation of pituitary stem cells. We ans others discovered the existence of a stem cell niche in the pituitary. Parench...

Background and aimsLifestyle modifications based on diet and exercise are common strategies for the treatment and prevention of obesity and related comorbidities. However, not all patients respond equally to similar weight loss intervention which compromise patient adherence. Strategies for predicting the individual response are required for improving intervention efficiency by personalized recommendations. microRNAs (miRNAs), small RNA particles which r...

IntroductionIn recent years, we have observed significant progress in cancer treatment associated with the development of immunotherapy. Nivolumab, an anti-PD-1 antibody, blocks the interaction between PD-1 and its ligands and inhibits the signaling pathway by preventing the tumor-derived PD-L1 from blocking T lymphocytes. In patients with metastatic melanoma, it is used either in monotherapy or in combination with other drugs. Immunotherapy is associate...

IntroductionAcromegaly is an uncommon chronic disease with an insidious course. Due to the high morbimortality it causes, its early diagnosis and treatment are priority. The three therapeutic pillars are surgery, pharmacological treatment and radiotherapy, alone or in combination.ObjectivesTo clinically, biochemically and histologically characterize patients with acromegaly under follow-up in a tertiary hospi...

Rothmund-Thomson syndrome (RTS) usually presents with physical stigmata (poikiloderma, ectodermal dysplasia, juvenile cataracts…) and it´s associated with malignancies in patients with homozygous or compound heterozygous mutations in the RECQL4 helicase gene (RTS-II). Neoplasms include osteosarcoma in childhood and skin cancer later in life, with occasional malignancies affecting other tissues (leukemia, lymphoma and gastrointestinal adenocarcinomas). To ou...

IntroductionMalignant insulinoma is a rare pancreatic neuroendocrine tumor that accounts for only 10% of all cases of insulinoma. The clinical picture is characterized by the presence of severe hyperinsulinemic hypoglycaemic syndrome in a patient with pancreatic tumor with locoregional and/or distant metastases. Therapeutic management is challenging due to the need to control both hypoglycemic syndrome and tumor growth. Curative surgery is rarely applica...

Introduction: Lutetium-177-DOTATATE (Lu177) is approved in patients with well-differentiated (G1 and G2) neuroendocrine tumors (NETs) positive to somatostatin receptors, progressive and unresectable or metastatic. Lu177 has been shown to increase progression-free survival and the quality of life of these patients.Material and Methods: Retrospective descriptive study of a series of 15 cases with NETs treated with Lu177. Demographic data, tumor characteris...

Background and aimsNonalcoholic fatty liver disease (NAFLD) is a major health threat in both developed and developing countries and is a precursor of the more advanced liver diseases including nonalcoholic steatohepatitis (NASH), liver cirrhosis and liver cancer. One of the numerous molecules participating in the development of liver steatosis is p63. Although p63 is mainly known for its roles as a tumor suppressor and cell maintenance and renewal, we ha...