Endocrine Abstracts

Introduction: The emergence of a new generation of antidiabetic drugs (GLP-1RA and SGLT-2i) with complementary mechanisms of action offer new alternatives in the treatment of patients with T2D and poor metabolic control.Objectives: To evaluate the efficacy of the aGLP-1 and iSGLT2 combination on metabolic control, weight, blood pressure and insulin dose in patients with DM2.Methods: Observational, retrospective study. We studied T2...

Background: Poorly differentiated neuroendocrine carcinoma (NEC) is an aggressive malignancy comprising both pulmonary and extrapulmonary primary sites. NEC includes both small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC). The optimal systemic therapy beyond first line platinum and etoposide is not established. There is a critical need to improve upon the median survival in the second line, as most patients do not survive more than 6 months. The effi...

Magnesium disorders are common in clinical practice. Hypomagnesemia is seen in inherited disorders, with excessive gastrointestinal or renal losses and due to medications. Replacement of magnesium can be challenging, with oral replacement strategies being generally more effective at slowly replacing body storages and intravenous (iv) replacement being more effective at treating life-threatening and severe cases of hypomagnesemia.Objective, material and m...

Introduction: Disease-related malnutrition is one of the main factors associated with morbidity and mortality in cancer patients. Furthermore, maintaining and improving muscle mass and function are important to achieve an optimal nutritional status. In this sense, the role of leucine-enriched essential amino acids supplementation for the therapeutic approach to the promotion of muscle anabolism stands out.Methods: 46 cancer patients with malnutrition rec...

Background: Heart failure (HF) is a chronic inflammatory syndrome, with increased morbidity, mortality, and decreased quality of life. The publication of GLIM criteria has standardized the diagnosis of malnutrition. With these criteria, the nutritional status of patients with heart failure, who usually have normal weight, overweight or obesity, has acquired a new perspective, since malnutrition may affect the clinical evolution and prognosis of these patients.<p class="abs...

Background: Heart failure (HF) has a rising incidence and is one of the most prevalent diseases worldwide. Serum NT-proBNP and systolic ejection fraction correlate with the severity and prognosis of this condition. The nutritional evaluation of patients with HF, who usually have normal weight, overweight or obesity, has acquired a novel approach due to the incorporation of novel techniques (bioelectrical impedance, nutritional ultrasonography), and functional tests.<p clas...

Introduction: Differentiated thyroid cancer (DTC) represent 85- 90 % of all thyroid cancer cases. Most of these have an excellent prognosis with standard treatment. However, between 7 and 23% will develop distant metastases and, of these, more than 65% will become radioactive iodine-refractory. In some of these patients who are considered to be radioiodine-refractory with rapidly progressive or symptomatic disease, or in patients who are not candidates for other therapies, the...

Objectives: Some authors have defined subtypes within gestational diabetes (GD) based on the calculation, from glucose and insulin levels during oral glucose overload (OGTT), of indices of insulin sensitivity (Matsuda) and insulin secretion (Stumvoll). Powe et al [1] found that 30% of women with GD had predominantly low insulin secretion, 51% low insulin sensitivity and 18% both (mixed). The aim of this work is to analyze the correlation of these indices with other kn...

Objective: The aim of this study is to evaluate the effectiveness of once-weekly exenatide on metabolic control, weight, blood pressure, and lipid profile in obese patients with type 2 diabetes (T2DM), and to assess possible predictive factors of response.Material and methods: Retrospective observational study, conducted with adult obese (BMI ≥30 kg/m2) T2DM subjects that had been initiated once-weekly exenatide following routine clinica...

Introduction: Squamous cell thyroid carcinoma is a very rare malignant epithelial tumour. It presents as rapid growth cervical mass, may affect neighbour structures and sometimes metastasizes other parts of the body. It’s often associated with previous goiter history and occasionally with autoimmune thyroiditis. It can appear pure, as a component of undifferentiated carcinoma, or combined with differentiated carcinoma areas (papillary or follicular).<p class="abstext"...