Endocrine Abstracts

Polycystic Ovary Syndrome increases the risk of cardiovascular diseases. To factors predisposing to cardiovascular diseases belong: hypertension, lipid and carbohydrate profiles, smoking and reduced physical activity. The aim of this study was to determine the association between selected factors predisposing to cardiovascular diseases and anthropometric parameters and CRP concentration in women with Polycystic Ovary Syndrome. The study was conducted amongst 43 women, aged 18-...

Introduction: Graves’ disease (GD) is associated with cardiac complications like tachydysrythmias, coronary ischaemia and cardiomyopathy. They are uncommon in the young. We present three individuals without previous cardiac disease, who developed significant cardiac complications of GD.Case presentations Subject 1: A 34-year-old female smoker, presented with breathlessness, palpitations, tremors and agitation for several weeks. Her fT4 was ...

IntroductionInadequate low serum of 25(OH) vitamin D leads to skeletal effect (rickets, osteoporosis, osteomalacia) and furthermore exhibits nonskeletal effects – increase the risk of cardiovascular diseases, type 2 diabetes, mental illness and many others. Vitamin D deficiency is associated with a severe morbidity burden and low functional performance among elderly patients. A long length-of-stay (LOS) among elderly patients is related to revere mo...

Introduction: It is well known that DHEA and DHEA-S has and impact on lipid metabolism, cardiovascular system and others. De Castro et al. showed that cortisol/DHEA-S ratio was an independent predictor of long-term mortality in patients with sepsis. Chronic inflammation is an important factor in cardiovascular diseases development that reduce quality and life expectancy. CVDs are more common in patients with adrenal incidentaloma than in general population. Literature data on ...

Introduction: Polycystic ovary syndrome (PCOS) is associated with an increased risk of abdominal obesity, what is regulated by numerous genetic, epigenetic, and environmental factors. MicroRNAs (miRNAs) are known regulators of gene expression, involved in the development of metabolic disturbances. Dual-energy X-ray absorptiometry (DXA) is an accurate method of body composition analysis. The aim of the present study was to investigate the association between circulating miRNAs,...

Introduction: Polycystic ovary syndrome is complex endocrine disorders, characterized by ovulatory dysfunction, hyperandrogenism and polycystic ovarian morphology. Those are lipid abnormalities, hyperinsulinemia, insulin resistance, impaired glucose metabolism, type 2 diabetes mellitus, metabolic syndrome, hyperandrogenism, oxidative stress and infertility. The visceral adiposity index (VAI) is a reliable marker of adipose tissue abnormalities in women with PCOS. A body shape ...

Introduction: Polycystic ovary syndrome (PCOS) contributes to endocrine and metabolic complications. Cardiovascular disease (CVD) is a leading cause of mortality and morbidity worldwide. Identification of the subpopulations with a higher risk of developing CVD and lipid metabolic disorders is crucial, particularly in PCOS patients.Aim: The aim of this study was to investigate the usefulness of new anthropometric indices such as BAI, VAI, LAP, BRI, ABSI a...

Background: Sclerostin is a protein secreted by osteocytes, that inhibits Wnt/ βcatenin signaling and was suggested to play a role in glucocorticoid-induced osteoporosis in mice. In humans data are inconsistent. Patients with primary adrenal insufficiency need lifelong replacement therapy with glucocorticoids and mineralocorticoids, which may influence their bone quality.Aim: The aim of the study was to evaluate sclerostin concentrations, densitomet...

Objectives: SARS-Cov2 infection can lead to severe cytokine storm especially in obese patients. It is known that the cytokine storm might lead to severe clinical manifestations or even acute mortality in critically ill patients with COVID-19. Ghrelin as well as leptin can act as the proinflammatory cytokines. The essential question is whether the cytokine storm in COVID-19 patients with obesity is associated with adipokines dysregulation.Aim: The st...

Introduction: The prevalence of obesity in elderly population increased. Obesity leads to increased morbidity and mortality as well as worsens quality of life in older individuals. Body-mass index (BMI) is the most widely used adiposity index. BMI correlates with body fatness but this index does not account for fat mass versus fat-free mass. Recently a new index of body adiposity the body adiposity index (BAI) was introduced. This novel index correlates well (in comparison to ...