Endocrine Abstracts

Introduction: Homeostasis of calcium and phosphor influence bone metabolism. They depend on several hormones, including parathyroid hormone, thyroid and sexual hormones. Low bone mass seems a common issue in endocrine disorders. The aim of this study is to identify the different endocrine disorders in patients with low bone mass.Methods: Retrospective study collecting the medical files of patients followed in the endocrinology department of Charles Nicol...

Introduction: Diabetes is a chronic, progressive disease characterized by elevated levels of blood glucose. In type 1 diabetes, some patients experience a “honeymoon period” shortly after diagnosis, wherein insulin needs decrease significantly and a few studies have demonstrated that drug-free glycemic control can be achieved in type 2 diabetes. We describe 2 unusual cases of endogenous hyperinsulinism and diabetes remission.Case presentation 1...

Introduction: Multiple endocrine neoplasia (MEN1) is a rare underdiagnosed inherited multi-tumor syndrome, affecting neuroendocrine and non-endocrine tissues. Its aspects are extremely variable with no genotype-phenotype correlation.Case report: A 57 year old woman with a history of hypertension, presented five months before her admission with asthenia, headache and vomiting, initial biological exams revealed a central hypothyroidism. A pituitary MRI sho...

Introduction: Since the hypothalamic-puituitary axis (HPA) is a radiosensitive region, cranial radiotherapy for head and neck malignancies represents a major risk factor for the development of endocrine complications particularly hypopituitarism.Case report: A 22 years old girl with a history of a undifferentiated carcinoma of nasopharyngeal type UCNT at the age of 09 years old treated with radiotherapy and chemotherapy was referred to the endocrinology ...

Introduction: Graves disease is a frequent etiology of hyperthyroidism. It is defined as a diffuse hyperfunctioning of the thyroid gland caused by an autoimmune disorder. We herein present a rare case of unilateral Graves disease involving the right lobe of the thyroid.Observation: A 44-year-old woman was referred for investigation of subclinical hyperthyroidism revealed by a routine check-up. On physical examination, she had tremor, eyelid retraction, t...

Introduction: Thyrotoxicosis is an uncommon cause of cholestasis. It’s a diagnostic challenge considering the broad differential diagnosis. Herein we report a case of Grave’s disease revealed by severe cholestatic jaundice.Observation: A 46 old male with a history of Sickle cell disease complained of diarrhea and significant weight loss for eight months, followed the last month by palpitations, heat intolerance, anxiety, insomnia and progressiv...

Introduction: Excessive production of growth hormone (GH) in acromegaly is most commonly caused by a somatotroph pituitary adenoma. The therapeutic arsenal is based on selective transsphenoidal adenomectomy (STA) as a first-line treatment. The aim of our study was to determine predictive factors of postoperative biochemical remission in acromegalic patients.Methods: We conducted a retrospective study including 18 acromegalic patients followed-up in the e...

Introduction: The management of acromegaly is commonly based on selective transsphenoidal adenomectomy (STA) as a first-line treatment, and other therapeutic options including somatostatin analogues (SA), dopamine agonists (DA) and radiotherapy as second-line treatment or in case of operative contraindications. The aim of our study was to assess the remission rate and to determine the predictive factors for long-term remission in acromegalic patients.Met...

Introduction: Somatotropin macroadenomas are associated with a considerable risk of ophthalmological impairment. The aim of our study was to determine the prevalence of ophthalmological complications and their associated factors in patients with acromegaly.Methods: We conducted a retrospective study including 28 patients with somatotropin adenomas and followed in the endocrinology department of Charles Nicolle Hospital. Clinical, biochemical and imaging ...

Introduction: Acromegaly results from an autonomous hypersecretion of growth hormone (GH) typically by a pituitary adenoma, commonly revealed by a dysmorphic syndrome. The aim of our study was to describe clinico-biological and radiological features of acromegaly.Methods: We conducted a retrospective study including 28 patients with acromegaly followed in the endocrinology department of Charles Nicolle Hospital. Clinical, biochemical, ophthalmological an...