Searchable abstracts of presentations at key conferences in endocrinology

ea0085p49 | Adrenal 2 | BSPED2022

Effect of high-dose maternal steroids on neonatal adrenal function

Ahmed Aneeq , Gopalakrishna Nagapratheek , Hattangadi Ibani , De Silva Shamani , Ferguson Elspeth , Elder Charlotte

Background: Limited data support concerns that corticosteroid use in pregnancy, for maternal health reasons, can suppress the neonatal Hypothalamic-Pituitary-Adrenal (HPA) axis. We sought to determine if neonates born to mothers on high-dose steroids are at risk of adrenal suppression.Methodology: Our tertiary neonatal unit guidance advises that babies born to mothers receiving ≥7.5 mg/day prednisolone for 28 consecutive days in the 3rd trimester u...

ea0090p43 | Calcium and Bone | ECE2023

Primary hyperparathyroidism in an adolescent presenting with genu valgus progressing to extensive bone disease; a case report

Lakshitha de Silva Nipun , Denagama Jayalath Mihiran , W. K. Chaminda Sampath , Perera Ranga , Karunathilake Chandana

Background: Primary hyperparathyroidism which is rare in adolescents presents commonly with non-specific symptoms and systemic complaints. Though there are few reported cases of genu valgus, progression to extensive bone disease with fractures has not been commonly reported. Additionally, hypercalcaemia at the time of presentation was almost universal.Case presentation: A 12-year-old male had been evaluated for bilateral (left > right) genu valgus an...

ea0090p217 | Thyroid | ECE2023

Autoimmune thyroid disease: a risk factor for thyroid cancer?

Salome Serranito Maria , Cunha Nelson , Abegao Matias Alexandra , Sabino Teresa , Milheiro Adelaide , Silva-Nunes Jose

Introduction: Some studies suggest a possible link between autoimmune thyroid disease (AITD) and thyroid cancer (TC). However, existing data is inconsistent, and no consensus exists regarding this question.Objective: The aim of this study was to analyze the association between TC and AITD, namely Hashimoto’s thyroiditis (HT) and Graves’ disease (GD).Methods: We conducted a retrospective and observational study of all pati...

ea0090ep53 | Adrenal and Cardiovascular Endocrinology | ECE2023

Metabolic syndrome and primary bilateral macronodular adrenal hyperplasia

Matias Alexandra Abegao , Bouca Bruno , Gutu Olga , Prokop Joanna , Sabino Teresa , Silva-Nunes Jose

Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare entity. Up to 1/3 of patients with incidental bilateral adrenal nodules presents biochemical evidence of hypercortisolism responsible for obesity, diabetes mellitus (DM), arterial hypertension or dyslipidemia. Its insidious course and nonspecific signs explain the underdiagnosis of this entity.Objective: To describe the case of a patient with metabolic syndrome (MS) with h...

ea0090ep609 | Endocrine-related Cancer | ECE2023

Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) of pancreas with typical insulinoma presentation

Serranito Maria Salome , Cunha Nelson , Vigia Duarte Emanuel , Silva-Nunes Jose

IntroductionMixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) of the pancreas are composed of two morphologically different components, each representing at least 30% of the tumor: ductal or acinar adenocarcinoma and neuroendocrine neoplasm (NEN). They are extremely rare tumors whose etiopathogenesis and biological behavior are not fully understood. Given its rarity, we describe a case of insulinoma in the context of MiNEN....

ea0090ep703 | Pituitary and Neuroendocrinology | ECE2023

Silent pituitary macroadenomas – clinical behavior and prognosis

Manique Ines , Amaral Sara , Palha Ana , Cortez Luisa , Cerqueira Luis , Sagarribay Amets , Silva-Nunes Jose

Introduction: A third of pituitary adenomas are non-functioning. Classification depends on adenohypophyseal hormones expression and transcription factors.Aim: Characterize silent pituitary macroadenomas cases regarding their clinical data, treatment, histopathology and prognosis.Methods: We revised clinical process of patients followed in CHULC. Cases with non-access to clinical follow-up registries or exams were excluded.<p cl...

ea0090ep717 | Pituitary and Neuroendocrinology | ECE2023

Bilateral petrosal sinus sampling – a 15-year experience from a tertiary hospital

Ferreira Helena Urbano , Goncalves Juliana , Belo Sandra , Alves Goncalo , Silva Maria Luis , Carvalho Davide , Freitas Paula

Introduction: In patients with ACTH-dependent Cushing Syndrome, differentiating between pituitary and ectopic sources can be challenging. Noninvasive testing can be performed, but bilateral inferior petrosal sinus sampling (BIPSS) remains the gold standard. In the last years however, novel imaging modalities, namely 3T-MRI with 3-dimensional spoiled gradient-echo sequence and 68Ga-tagged CRH combined with positron emission tomography, have been proposed as alternatives.<p ...

ea0063p493 | Calcium and Bone 2 | ECE2019

Hypocalcemic cardiomyopathy: a reversible entity?

Santos Tiago Da Silva , Carvalho Andre Couto de , Romao Raquel , Cruz Celia Maio , Cardoso Helena

Introduction: Hypocalcaemia is a rare and potentially reversible cause of cardiomyopathy. Restoration to normal serum calcium levels usually leads to rapid improvement of cardiac function.Case report: A 42-year-old woman with a history of total thyroidectomy, due to large nodular goiter in 2016, and acute pos-operative hypoparathyroidism, assumed to be transient, with no supplementation since early 2017. In September 2018 she was admitted due to acute ca...

ea0063p760 | Thyroid 2 | ECE2019

NMR-measured subfractions of HDL-cholesterol through thyroid function spectrum

Janovsky Carolina Castro Porto Silva , Bittencourt Marcio Sommer , Goulart Alessandra , Lotufo Paulo A , Bensenor Isabela M

Thyroid dysfunction has been traditionally related to several lipid abnormalities. Indeed, even within the normal range of thyroid-stimulating hormone (TSH) values, a linear increase in total cholesterol, low-density lipoprotein cholesterol and triglycerides and a linear decrease in high-density lipoprotein cholesterol (HDL-C) levels has been observed with increasing TSH. With respect to serum high-density lipoprotein (HDL) cholesterol concentrations, high, normal, or low valu...

ea0063p1195 | Thyroid 3 | ECE2019

Amiodarone-induced thyrotoxicosis: when combined treatment is an option

Silva Diana , Ruas Luisa , Cunha Nelson , Catarino Diana , Fadiga Lucia , Guiomar Joana , Carrilho Francisco

Introduction: Amiodarone is an effective drug in the management of supraventricular arrhythmias. Due to its composition rich in iodine and pharmacological properties can cause thyroid dysfunction in 15–20% of the treated patients. Clinically it can present in the form of amiodarone-induced hypothyroidism or amiodarone-induced thyrotoxicosis. This latter situation may result from an excess of iodine supply, glandular destruction or both pathogenic mechanisms.<p class="...