Searchable abstracts of presentations at key conferences in endocrinology

ea0049s25.1 | HPA axis regulation during a woman's life: impact on metabolic outcomes | ECE2017

HPA axis regulation during a woman’s life: impact on metabolic outcomes

Damjanovic Svetozar

Aging in both men and women is linked with a decline in diurnal variations in cortisol secretion. Cortisol secretion is increased during circadian nadir and possibly in total through the day. Reduced suppressibility of cortisol after dexamethasone (DEX) administration and increased ACTH secretion with aging are well documented. It appears that aging associates with the decrease in cortisol negative feedback efficacy on HPA axis due to underexpression of mineralocorticoid recep...

ea0037ep1205 | Clinical Cases–Pituitary/Adrenal | ECE2015

Bilaterally slipped capital femoral epiphysis in growth hormone–deficient patient: osteosynthesis also needs the oestrogen epiphyseal fusion- case report

Tesic Dragan , Mitrovic Milena , Vlaski Jovan , Damjanovic Svetozar , Popovic Vera

Introduction: Growth without growth hormone is seen also in patient with craniopharyngioma. We just speculate what anabolic factors might be involved in this process. However, oestrogen through its receptors lead to epiphyseal fusion. In this case report we would like to present the patient with bilateral slipped femoral epiphysis (SFE) and interventions made at tertiary health care level.Case report: 20-years-old female, operated from craniopharyngioma ...

ea0041ep1026 | Thyroid (non-cancer) | ECE2016

Depression and anxiety in hashimoto thyroiditis after long-term levothyroxine replacement

Djurovic Marina , Pereira Alberto , Jemuovic Zvezdana , Vasovic Olga , Pavlovic Dragan , Petakov Milan , Miljic Dragana , Damjanovic Svetozar

Introduction: Thyroid dysfunction may cause various psychiatric symptoms and disturbances. In addition, many factors affect the variable responses to hormone replacement. Many patients treated for Hashimoto thyroiditis(HT) report persistent impairments in general well-being despite long-term L-thyroxine (LT4) replacement and restoration of biochemical euthyroidism.Aim: To investigate the prevalence of depression and anxiety in patients with HT on long-te...

ea0037gp.26.01 | Thyroid – hypothyroidism | ECE2015

Quality of life in primary hypothyroidism after long-term levothyroxine replacement

Djurovic Marina , Pereira Alberto , Vasovic Olga , Jemuovic Zvezdana , Pavlovic Dragan , Petakov Milan , Salak Biljana , Damjanovic Svetozar

Introduction: There is an increasing awareness for intrinsic imperfections of endocrine replacement therapy affecting general well-being in the long-term. For thyroid hormone, many factors affect the variable responses to hormone replacement, like common genetic variations in deiodinase and thyroid hormone transport proteins, and the inability to provide adequate individual combined T4 and T3 therapy. Despite levothyroxine (L-T4)...

ea0029p1119 | Neuroendocrinology | ICEECE2012

Ghrelin, leptin and adiponectin plasma levels in narcolepsy with cataplexy

Lakocevic M. , Petakov M. , Barisic M. , Radosavljevic B. , Antic J. , Damjanovic S.

Introduction: Narcolepsy is a rare sleep disorder characterized by excessive daytime sleepiness and REM-sleep abnormalities. Lateral hypothalamic hypocretin/orexin neurones are critical for normal wakefulness and energy expenditure, and the reduction of their activity has been linked with narcolepsy. Their activity is inhibited by extracellular glucose and the ‘satiety’ hormone leptin but stimulated by the ’hunger’ hormone ghrelin. Patients with narcolepsy ...

ea0029p1429 | Pituitary Clinical | ICEECE2012

Synergistic effects of combined stimulation with CRH+ghrelin on ACTH and cortisol responses in patients with Cushing’s disease: a pilot study

Miljic D. , Doknic M. , Pekic S. , Stojanovic M. , Damjanovic S. , Popovic V.

Background: Several stimulatory tests for differential diagnosis of ACTH dependent Cushing’s syndrome are avilable, CRH being the most valuable test in patients with Cushing’s disease (CD). Exaggerated responses to ghrelin have also been shown in patients with CD mainly due to overexpression of GHS receptors on corticotrope tumor cells. However, the effects of combined stimulation with CRH+ghrelin on ACTH and cortisol secretion have not been tested before in these pa...

ea0029p1696 | Thyroid (non-cancer) | ICEECE2012

Thyroid concentrations and leptin levels in patients with anorexia nervosa

Nikolic Djurovic M. , Jankovic D. , Petakov M. , Antic J. , Damjanovic S.

Anorexia nervosa (AN) is known as a state of gonadotrophin and leptin deficiency. Leptin, the product of OB gene, secreted by adipocytes, is proved to play an important role in regulating apetite and energy expenditure. Thyroid hormones are Important regulators of total energy expenditure are thyroid hormones and also are able to increase oxygen consumption by tissues. The aim of the study was to evaluate a possible interaction of thyroid hormones (T3, T4...

ea0026p46 | Endocrine disruptors | ECE2011

Bone remodeling parameters and bone mass in patients with schizophrenia treated with long-acting injectable risperidone

Doknic M , Bojovic N Maric , Pekic S , Britvic D , Damjanovic A , Gasic M Jasovic , Popovic V

Introduction: Studies suggest that schizophrenia and prolactin raising antipsychotics, one of them being risperidone, may be associated with low bone mass. On the other hand, weight gain as a consequence of antipsychotics in these patients may be the protective factor against osteoporosis.Objective: Determine bone remodeling parameters and bone mass in patients with schizophrenia treated with long-acting injectable risperidone (LAIR) under naturalistic c...

ea0026p108 | Female reproduction | ECE2011

Relation of insulin resistance and lipid peroxidation in non-obese women with polycystic ovary syndrome

Macut D , Lissounov A , Bozic I , Simic T , Bjekic J , Petakov M , Damjanovic S , Savic-Radojevic A

Introduction: Polycystic ovary syndrome (PCOS) is a frequent metabolic disorder in women of the reproductive age, and is characterized by multi-factorial cardiovascular risk factors. Insulin resistance is proposed as a central factor linking PCOS to increasing risk of cardiovascular disease. The aim of our study was to explore a link between insulin resistance and oxidative stress, as a predictor of cardiovascular risk, in young, non-obese PCOS women.Met...

ea0026p183 | Neuroendocrinology | ECE2011

Hipothalamo–pituitary–adrenal axis function in posttraumatic stress disorder

Bozic I , Macut D , Popovic B , Isailovic T , Petakov M , Ognjanovic S , Bogavac T , Damjanovic S

Introduction: Posttraumatic stress disorder (PTSD) is anxious disorder that occurs following exposure to trauma. In the last two decades, numerous studies showed that dysregulation of hipothalamo–pituitary–adrenal axis (HPAA) is a core feature of the PTSD. Still, results are heterogeneous and often conflicted with one another. Therefore, we conducted strictly controlled study in order to characterize relationship between ACTH and cortisol secretion in patients with c...