Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep309 | Calcium and Vitamin D metabolism | ECE2015

Parathyroid hormone therapy for postoperative resistant hypocalcaemia

Akin Safak , Bayraktar Miyase , Gurlek Alper

Introduction: No consensus guideline on the treatment of hypoparathyroidism. Hypoparathyroidism is a disease characterized by hypocalcaemia and insufficient PTH. Conventional therapy includes calcium and active vitamin D supplementation, often in large doses.Case report: A 31-year-old woman presented with hypercalcemia. Serum calcium and phosphorus levels were 10.5 and 2.56 mg/dl respectively. The serum PTH level was increased (1619 pg/ml). The serum 25-...

ea0032p1006 | Thyroid (non-cancer) | ECE2013

Prevalance of GH deficiency in Turkish patients with Hashimoto's thyroiditis: a single center experience

Akin Safak , Aydin Kadriye , Gurlek Alper

Background and Aim: Prevalence of Hashimoto’s thyroiditis is increasing in Turkey. GH deficiency has been reported to associate with this disorder in several different ethnic population. The aim of this study was to evaluate GH deficiency in the population with Hashimoto’s thyroiditis.Materials and methods: Euthyroid Hashimoto’s thyroiditis patients, who admitted to the Department of Endocrinology and Metabolism of Hacettepe University, we...

ea0035p917 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Treating prolactinoma by endoscopic endonasal pituitary surgery: surgical experience of 151 cases

Akin Safak , Berker Mustafa , Isikay Ilkay , Gurlek Alper

Background and Aim: Prolactinoma is the most common type of functional pituitary tumor in adults. Giant prolactinomas are defined as tumors achieve a diameter >4 cm and often have very high serum prolactin level. In our previous study showed that endoscopic endonasal pituitary surgery is a very convenient procedure for the patient due to low morbidity and high efficiency. In this study we evaluated endoscopic endonasal pituitary surgery series in patients with prolactinoma...

ea0032p593 | Female reproduction | ECE2013

Low dose oral contraceptive use and the risk of thrombosis in polycystic ovary syndrome

Akin Safak , Cinar Nese , Aydin Kadriye , Akman Umit , Buyukasik Yahya

Background and aim: Oral contraceptives (OC) are the mainstay of long-term treatment for women with polycystic ovary syndrome (PCOS). OC use is associated with increased risk of venous thromboembolism. The aim of the present study was to determine whether treatment with a low dose OC induce changes on coagulation and fibrinolysis in women with PCOS.Materials and methods: Sixteen lean, normal-glucose tolerant patients with PCOS (mean age, 22.4±2.4 ye...

ea0049ep1097 | Female Reproduction | ECE2017

Frequency of nodular goiter and autoimmune thyroid disease and association of these disorders with insulin resistance in polycystic ovary syndrome

Karakose Mellia , Hepsen Sema , Cakal Erman , Arslan Muyesser , Tutal Esra , Akin Safak , Unsal Ilknur , Ozbek Mustafa

Background and aim: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder in women with reproductive age. Nodular goiter and autoimmune thyroid disease (AITD) are frequently seen endocrinological abnormalities. The aim of this study was to identify the prevalence of AITD and nodular goiter in PCOS patients and investigate whether PCOS related hormones and metabolic factors affect these thyroid disorders.Methods: Ninety-seven with ...

ea0035p48 | Adrenal cortex | ECE2014

Retrospective analysis of adrenal ıncidentalomas: a single center experience

Akin Safak , Helvaci Nafiye , Dagdelen Selcuk , Yildiz Bulent Okan , Gurlek Alper , Erbas Tomris , Bayraktar Miyase

Background and aim: Incidentally discovered adrenal masses (adrenal incidentalomas (AI)), generally 1 cm or more in diameter, are mostly benign and asymptomatic and are often considered as nonfunctional tumors. The aim of this study was to perform the imaging characteristics, endocrinologic screening and histologic diagnoses of adrenal incidentaloma cases encountered in our institute.Methods: This retrospective evaluation of patients with AI includes 543...

ea0032p62 | Adrenal cortex | ECE2013

Metastatic adrenocortical carcinoma presenting with concomitant secretion of glucocorticoid, mineralocorticoid, androgen, and catecholamines: a case report

Akin Safak , Dagdelen Selcuk , Yuksel Elif , Altindag Kadri , Sayek Iskender , Baydar Dilek Ertoy , Erbas Tomris

Introduction: We report the first case of metastatic adrenocortical carcinoma (ACC) concomitantly secreting cortisol, aldosterone, catecholamines and androgens with the extensive distant metastasis at the time of diagnosis.Case report: A 57-year-old woman referred for left adrenal mass (5.5×4.0 cm) two years after the diagnosis of breast cancer. The patient’s medical history revealed hypertension and diabetes mellitus. She has cushingoid and hy...

ea0032p369 | Diabetes | ECE2013

Relation of serum chemerin level with markers of atherosclerosis in diabetes and prediabetes

Aydin Kadriye , Canpolat Ugur , Dural Muhammet , Akin Safak , Karakaya Jale , Aytemir Kudret , Gurlek Alper

Introduction: Chemerin is a novel adipokine that is correlated with adipocyte differentiation, glucose metabolism and inflammation, but its role remains to be elucidated in atherosclerosis particularly in diabetes and prediabetes. We aimed to investigate the relation of serum chemerin levels with markers of atherosclerosis as exemplified by pulse wave velocity (PWV), carotid intima media thickness (CIMT), and carotid plaque presence in these groups.Metho...

ea0026p444 | Thyroid (non cancer) | ECE2011

Regulation of visceral adipose tissue-derived serin protease inhibitor in overt and subclinical hypothyroid patients

Cinar Nese , Gulcelik Nese Ersoz , Aydin Kadriye , Akin Safak , Usman Aydan , Gurlek Alper

Introduction: Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a novel adipocytokine which might exert an insulin-sensitizing effect. It is thought that vaspin mRNA expression may be a compensatory mechanism associated with obesity and insulin resistance. Given the fact that subclinical and overt hypothyroidism are known risk factors for insulin resistance, we aimed to assess the regulation of vaspin by thyroid hormones in humans.Met...

ea0022p351 | Diabetes | ECE2010

Increased serum nesfatin-1 levels in patients with impaired glucose tolerance

Gulcelik Nese Ersoz , Akin Safak Cavus , Aksoy Duygu Yazgan , Karakaya Jale , Usman Aydan

Objective: Nesfatin was found to be co-localized with insulin in pancreatic β cells and its levels were decreased in type 2 diabetic patients. In order to investigate the role of nesfatin in carbohydrate metabolism, we measured baseline nesfatin-1 levels and its response to glucose load in patients with impaired glucose tolerance (IGT) and in healthy subjects.Subjects and methods: Fourteen patients with IGT and, 13 age and body mass index matched co...