Endocrine Abstracts

Introduction: No consensus guideline on the treatment of hypoparathyroidism. Hypoparathyroidism is a disease characterized by hypocalcaemia and insufficient PTH. Conventional therapy includes calcium and active vitamin D supplementation, often in large doses.Case report: A 31-year-old woman presented with hypercalcemia. Serum calcium and phosphorus levels were 10.5 and 2.56 mg/dl respectively. The serum PTH level was increased (1619 pg/ml). The serum 25-...

Background and Aim: Prevalence of Hashimoto’s thyroiditis is increasing in Turkey. GH deficiency has been reported to associate with this disorder in several different ethnic population. The aim of this study was to evaluate GH deficiency in the population with Hashimoto’s thyroiditis.Materials and methods: Euthyroid Hashimoto’s thyroiditis patients, who admitted to the Department of Endocrinology and Metabolism of Hacettepe University, we...

Background and Aim: Prolactinoma is the most common type of functional pituitary tumor in adults. Giant prolactinomas are defined as tumors achieve a diameter >4 cm and often have very high serum prolactin level. In our previous study showed that endoscopic endonasal pituitary surgery is a very convenient procedure for the patient due to low morbidity and high efficiency. In this study we evaluated endoscopic endonasal pituitary surgery series in patients with prolactinoma...

Background and aim: Oral contraceptives (OC) are the mainstay of long-term treatment for women with polycystic ovary syndrome (PCOS). OC use is associated with increased risk of venous thromboembolism. The aim of the present study was to determine whether treatment with a low dose OC induce changes on coagulation and fibrinolysis in women with PCOS.Materials and methods: Sixteen lean, normal-glucose tolerant patients with PCOS (mean age, 22.4±2.4 ye...

Background and aim: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder in women with reproductive age. Nodular goiter and autoimmune thyroid disease (AITD) are frequently seen endocrinological abnormalities. The aim of this study was to identify the prevalence of AITD and nodular goiter in PCOS patients and investigate whether PCOS related hormones and metabolic factors affect these thyroid disorders.Methods: Ninety-seven with ...

Background and aim: Incidentally discovered adrenal masses (adrenal incidentalomas (AI)), generally 1 cm or more in diameter, are mostly benign and asymptomatic and are often considered as nonfunctional tumors. The aim of this study was to perform the imaging characteristics, endocrinologic screening and histologic diagnoses of adrenal incidentaloma cases encountered in our institute.Methods: This retrospective evaluation of patients with AI includes 543...

Introduction: We report the first case of metastatic adrenocortical carcinoma (ACC) concomitantly secreting cortisol, aldosterone, catecholamines and androgens with the extensive distant metastasis at the time of diagnosis.Case report: A 57-year-old woman referred for left adrenal mass (5.5×4.0 cm) two years after the diagnosis of breast cancer. The patient’s medical history revealed hypertension and diabetes mellitus. She has cushingoid and hy...

Introduction: Chemerin is a novel adipokine that is correlated with adipocyte differentiation, glucose metabolism and inflammation, but its role remains to be elucidated in atherosclerosis particularly in diabetes and prediabetes. We aimed to investigate the relation of serum chemerin levels with markers of atherosclerosis as exemplified by pulse wave velocity (PWV), carotid intima media thickness (CIMT), and carotid plaque presence in these groups.Metho...

Introduction: Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a novel adipocytokine which might exert an insulin-sensitizing effect. It is thought that vaspin mRNA expression may be a compensatory mechanism associated with obesity and insulin resistance. Given the fact that subclinical and overt hypothyroidism are known risk factors for insulin resistance, we aimed to assess the regulation of vaspin by thyroid hormones in humans.Met...

Objective: Nesfatin was found to be co-localized with insulin in pancreatic β cells and its levels were decreased in type 2 diabetic patients. In order to investigate the role of nesfatin in carbohydrate metabolism, we measured baseline nesfatin-1 levels and its response to glucose load in patients with impaired glucose tolerance (IGT) and in healthy subjects.Subjects and methods: Fourteen patients with IGT and, 13 age and body mass index matched co...