Searchable abstracts of presentations at key conferences in endocrinology

ea0063p249 | Pituitary and Neuroendocrinology 1 | ECE2019

Spontaneous pregnancy obtained in persistent Cushing Disease treated with Cabergoline: Report of two cases

Vicente Almudena , Castro Enrique , Cruz Andrea , Castro Ana , Julia Sastre , Jose Lopez

Introduction: Pregnancy is rare in patients with Cushing Disease (CD) owing to ovulatory dysfunction. When surgery is not curative, medical treatment is usually considered. Ketoconazole and mitotane, commonly used medical therapies, have questionable teratogenicity and are not often options in pregnancy. Cabergoline was found to be effective in reducing hypercortisolism in Cushing’s disease. Observational studies suggested that low dose cabergoline treatment at the time o...

ea0049ep866 | Clinical case reports - Pituitary/Adrenal | ECE2017

Unprogrammed pregnancy in women with active Acromegaly: a case report

Luque-Fernandez Ines , Olivar-Azuara Monica , Llamazares-Iglesias Ofelia , Vicente Almudena

Introduction: Reports of pregnancy occurring in acromegalic patients are uncommon. Nevertheless, it appears that women are usually able to carry their pregnancy to full termCase: 39 year old woman referred to endocrinology for secondary amenorrhea and hyperprolactinemia (PRL 55.54 mg/dl). As she mentioned typical symptoms of Acromegaly, we extended the study, finding high levels of IGF1 and a pituitary macroadenoma (25×16 mm) in MRI. Presurgical tre...

ea0049ep973 | Pituitary - Clinical | ECE2017

Clinical, histological, molecular features and outcomes of craniopharyngiomas: Single centre experience in Toledo, Spain

Vicente Almudena , Moreno Beatriz , Olivar Monica , Martinez Ana , Mollejo Manuela , Sastre Julia , Lopez Jose

Background: Craniopharyngiomas (CPs) are epithelial tumors that typically arise in the suprasellar region. They are associated with high levels of morbidity related to tumour location and/or treatment-related injuries. Recent discoveries have also led to a better understanding of CP development and potential treatments.Objetive: To analyse the clinical, pathological, molecular features and outcomes of patients with CP.Design: Retro...

ea0041ep544 | Diabetes therapy | ECE2016

Potential glycemic overtreatment in diabetics patients older than 70 years and comorbid conditions: real-life experience

Vicente Almudena , Olivar Monica , Cortes Claudia , Martinez Ana , Sastre Julia , Pena Virginia , Canovas Barbara , Lopez Jose

Background: Optimal glucose management in older people is currently unclear. Recent guidelines recommend avoiding tight glycemic targets in elderly patients with comorbidities because intensive control is unlikely to achieve benefit and they are at higher risk of hypoglycaemia.Objective: To estimate the prevalence of potential overtreatment in older adults with diabetes mellitus and comorbidities.Design: Cross-sectional study.<...

ea0041ep576 | Diabetes therapy | ECE2016

Trends and differences between sexes in control of diabetes and cardiovascular risk factors from 2004 to 2014

Vicente Almudena , Cortes Claudia , Olivar Monica , Martinez Ana , Sastre Julia , Marco Amparo , Luque Ines , Lopez Jose

Background: Poorer control of risk factors for cardiovascular disease (cvd) has been reported in diabetic women compared with men.Objective: To investigate whether control of diabetes and risk factors for cvd differ between sexes in a cohort of diabetic patients monitored at an outpatient endocrinology clinic from 2004 till 2014.Design: Observational, retrospective cohort study.Patients and methods: A cohort ...

ea0037ep272 | Calcium and Vitamin D metabolism | ECE2015

Cinacalcet remains effective in primary hyperparathyroidism after 4 years of treatment

Luque-Fernandez Ines , Vall Florentino Del , Luque Alessandra , Vicente Almudena , Sastre Julia , Marco Amparo

Introduction: Cinacalcet is an oral calcimimetic indicated in treatment of primary hyperparathyroidism in patients who are unable to undergo parathyroidectomy: do not accept surgery, there is failure of previous surgery or serious comorbidity that makes surgery impossible.Methods: Descriptive study that includes nine patients with primary hyperparathyroidism who have completed at least 48 months of treatment with cinacalcet (seven patients refusal to par...

ea0035p90 | Bone and Osteoporosis | ECE2014

Familial hypocalciuric hypercalcemia: an important differential diagnosis from hyperparathyroidism

Luque-Fernandez Ines , Vicente Almudena , Luque Alessandra , Del Val Florentino , Garin Intza , Morlan Miguel Angel

Introduction: Familial hypocalciuric hypercalcemia (FHH) is a rare, benign, autosomal dominant condition usually caused by heterozygous inactivating mutations in the gene encoding the calcium sensing receptor (CASR).Case: 22-year-old woman referred to endocrinology for suspected polycystic ovary syndrome. Hypercalcemia is detected. Laboratory tests showed persistent hypercalcemia with a serum total calcium of 11.1 mg/dl (8.8–10.2), phosphorus 2.8, i...

ea0032p482 | Diabetes | ECE2013

Are there gender differences in liraglutide response in adults with type 2 diabetes?

Sastre Julia , Vicente Almudena , Maqueda Esther , Luque Ines , Castro Enrique , Marco Amparo , Pena Virginia , Lopez Jose

Background: Recent reports suggest that female sex could be an indicator of better response to liraglutide in patients included in clinical trials.Aim: To compare efficacy of liraglutide in women and men with type 2 diabetes mellitus (T2DM), in real clinical practice.Patients and methods: Our study included 116 patients with T2DM and obesity (BMI >30) attending outpatient clinic, which initiated with liraglutide (0.6 mg/daily f...

ea0016p807 | Thyroid | ECE2008

Clinical variables associated with recurrence of hyperthyroidism in Graves’ disease

Cristina Familiar , Inmaculada Moraga , Eva Cruces , Almudena Vicente , Julia Sastre , Jose Lopez

Introduction: In Graves’ hyperthyroidism with long-term antithyroid drugs (ATD) treatment, remission is often umpredictable. However variables at diagnosis or at the end of the ATD regimen are associated with a highest likelihood of recurrence and could be used to decide an ablative treatment.Objective: To identify variables before and at the end of a long-term treatment with ATD (>6 months) associated with higher rates of relapse during a follo...

ea0056p17 | Adrenal cortex (to include Cushing's) | ECE2018

Clinical and biochemical outcomes in surgically treated patients with primary aldosteronism. A multicentric retrospective study

Vicente Almudena , Sirvent Alejandro , Herranz Sandra , Lamas Cristina , Martinez Ana , Sastre Julia

Background: Although unilateral primary aldosteronism (PA) is the most common surgically correctable cause of hypertension, no standard criteria exist to classify surgical outcomes. The Primary Aldosteronism Surgical Outcome (PASO) study was an international project to develop consensus criteria for outcomes and follow-up of adrenalectomy for unilateral PA.Objetives: To determine the proportions of patients achieving complete, partial, or absent clinical...