Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep886 | Growth hormone IGF axis - basic | ECE2017

Nodular thyroid disease in acromegaly: cohort of 69 patients at a single institution

Alvarez-Escola Cristina , Gonzalez Diego Meneses , Dominguez Oscar Moreno , de la Morena Lucrecia Herranz

Materials and methods: The aims were to evaluate the frequency of nodular thyroid disease (NTD) in acromegalic patients and to correlate clinical and metabolic features with disease activity and other. We conducted a cross-sectional study including retrospectively 69 acromegalic patients attending to an University Hospital in Madrid, Spain between 1980 and 2016. Mean age was 63 (32–92) years, 63.8% of patients were female. Mean age at diagnosis of acromegaly was 48 (11&#1...

ea0032p712 | Neuroendocrinology | ECE2013

Effects of GH therapy in carbohydrate metabolism in spanish adults with GH deficiency

Andrea Parra Ramirez Paola , Perez Fernandez Laura , Fernandez Martinez Alberto , Grande Aragon Cristina , Alvarez-Escola Cristina

GH deficiency (GHD) in adults is characterized by a tendency towards fat mass gain and may predispose to type 2 diabetes mellitus.GH replacement (GHR) is associated with impaired insulin sensitivity shortly after starting therapy, reflected by increased fasting glucose and insulin levels. Available evidence suggests that concerns regarding glucose intolerance in patients receiving long-term GHR have not been substantiated. However, several environmental and lifestyle-related f...

ea0081ep821 | Pituitary and Neuroendocrinology | ECE2022

Preference of acromegaly patients for treatment attributes in Spain

Fajardo-Montanana Carmen , Alvarez Escola Cristina , Biagetti Betina , Centeno Rogelio Garci a , Ciriza Raquel , Sanchez Laura , Diaz Marcos

Background: Acromegaly is a slowly progressive rare disease caused by an increase in growth hormone secretion that causes a subsequent rise in insulin-like growth factor (IGF-1), both contributing to the excessive growth of the extremities, soft tissues and organs, in addition to other comorbidities directly interfering with patient’s quality of life. Acromegaly patients are concerned about their disease and their treatments, however, publications about patient’s opi...

ea0020p282 | Clinical case reports and clinical reports | ECE2009

Breast metastases by medullary thyroid carcinoma: case report with an update

Chimenti Elisa Moya , Santamaria Beatriz Lecumberri , Antonio Rosado Sierra Jose , Barquiel Alcala Beatriz , Felipe Pallardo Sanchez Luis , Alvarez Escola Cristina

Introduction: Medullary thyroid carcinoma (MTC) commonly metastasizes to cervical lymph nodes, liver, lungs and bone. Metastatic lesions in the breast have been previously reported but they are extremely rare and to our knowledge, this is the first case in literature described on a male patient. We report a case of a 49-year-old man with a 23-year history of sporadic MTC with bone, liver and lung metastases treated with somatostatin analogues for 6 years, who developed a painf...

ea0016p406 | Neuroendocrinology | ECE2008

Malignant diseases in our patients with acromegaly

Moya Chimenti Elisa , Alvarez Escola Cristina , Lecumberri Santamaria Beatriz , Fernandez Alberto , Garcia Dominguez Maria , Felipe Pallardo Sanchez Luis

Background: Acromegaly, a chronic disease caused by excess secretion of growth hormone (GH), has been known to reduce patients life expectancy. This increase in morbility and mortality is not only due to cardiovascular, respiratory or cerebrovascular disorders, but also to an increased risk for cancer.Subjects and methods: The aim of this study was to describe the associated malignant diseases among our fifty acromegalic patients. Clinical features of th...

ea0016p466 | Neuroendocrinology | ECE2008

Effects of growth hormone replacement in 28 patients with growth hormone deficiency

Martin-Borge Virginia , Alvarez Escola Cristina , Lecumberri Santamaria Beatriz , Garcia Dominguez Maria , Moya Chimenti Elisa , Pallardo Sanchez Luis Felipe

Aim: To evaluate the response to growth hormone (GH) replacement in patients with growth hormone deficiency (GHD) after 1 year of treatment in terms of body composition, carbohydrate metabolism, lipid metabolism and quality of life.Method and patients: Twenty-eight patients with GHD with the following characteristics: 16 males, 10 with radiotherapy and 18 with panhypopituitarism, were included in our study. Body mass index (BMI) and waist hip ratio (WHR)...

ea0056p70 | Adrenal cortex (to include Cushing's) | ECE2018

Adrenocortical carcinoma: retrospective analysis of a series of clinical cases

Salas Jersy Jair Cardenas , Catalan Arturo Lisbona , Goiburu-Chenu Belen , Esteban-Rodriguez Maria Isabel , Regojo Rita Maria , Alvarez-Escola Cristina

Introduction: Adrenocortical carcinoma (ACC) is a rare and aggressive tumour. At diagnosis 21% has metastasis. Even after complete surgical removal, patients are at risk of recurrence as late as 10-12 years. The 5-year survival rate of Stage I to IV (ENSAT 2008) is 82%, 61%, 50% and 13% respectively.Objetive: To describe the epidemiological and clinical characteristics, as well as the evolution, treatments and overall survival of patients diagnosed with ...

ea0037ep261 | Calcium and Vitamin D metabolism | ECE2015

Comparative effectiveness of biphosphonates and parathyroidectomy in osteoporosis related to primary hyperparathyroidism

Salas Jersy Jair Cardenas , Alcala Beatriz Barquiel , Alvarez-Escola Cristina , Santamaria Beatriz Lecumberri , Cortes Beatriz Pelegrina , Sanchez Luis Felipe Pallardo , Eslava Antonio Torrijos

Introduction: The use of Bisphosphonates could be a treatment option of osteoporosis secondary to primary hyperparathyroidism (OPHP) in patients not eligible or that refuse/reject surgery.Methods/design: We analysed data of 46 patients diagnosed of OPHP. Fourteen underwent surgery and 32 were treated with bisphosphonates at standard dose. Densitometric parameters and of calcium-phosphorus metabolism were analyzed before and after 1 and 2 years of treatme...

ea0041ep1118 | Thyroid cancer | ECE2016

Medullary thyroid cancer (MTC): descriptive analysis and prognostic factors in a multicenter study

Alcazar Victoria , Blanco Concepcion , Alvarez-Escola Cristina , Guijarro Guadalupe , Estrada Javier , De Miguel Paz , Palacios Nuria , Duran Alejandra , Carmen Montanes M. , Abad Ainhoa , Lecumberri Beatriz , Civantos Soralla , Aller Javier

Introduction: MTC accounts for 5% of thyroid cancers and can occur sporadically or as part of the multiple endocrine neoplasia type 2 syndrome (MEN 2). The objective of our study is to evaluate the prognostic factors and outcomes of patients with MTC in the community setting.Methods: Retrospective descriptive multicenter study of patients with histological diagnosis of MTC. Descriptive, bivariate analyses (Student t for cuantitative and ...

ea0056gp199 | Pituitary Basic | ECE2018

Prominent expression of MAX and MEG3, despite lack of mutations in MAX, suggest a potential role for 14q genes in pituitary adenomas

Ibanez-Costa Alejandro , Leton Rocio , Rivero-Cortes Esther , Alvarez-Escola Cristina , Poyo-Guerrero Paloma Rodriguez , Gavilan-Villarejo Inmaculada , Korbonits Marta , Marazuela Monica , Galvez-Moreno Maria Angeles , Soto-Moreno Alfonso , Robledo Mercedes , Castano Justo P , Luque Raul M

Pituitary adenomas (PA), as well as pheochromocytomas and paragangliomas, are neuroendocrine tumors that arise from cells derived from the pituitary, adrenal and extra-adrenal nervous system, respectively. Recent studies have identified a growing series of susceptibility genes for these pathologies. Some genes may be associated with the development of both types of pathologies, as it is the case for succinate dehydrogenase complex genes, while, PAs have not been reported to da...