Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep164 | Calcium and Bone | ECE2022

The clinical presentation of primary hyperparathyroidism during the Covid-19 pandemic

Castellano Elena , Borretta Giorgio , Pellegrino Micaela , Tassone Francesco , Craparo Andrea , Baffoni Claudia , Gianotti Laura

Background: In the last decades, the clinical profile of PHPT in Western Countries has changed from a highly symptomatic to a largely asymptomatic disease. However, a substantial stability in its clinical features has been reported in the last two decades. The usual management, including time to diagnosis and treatment, of PHPT during the Covid-19 pandemic has been changed and likely slowed down. Whether further changes in the clinical presentation of PHPT have occurred during...

ea0081ep304 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Empagliflozin and arterial stiffness in type 2 diabetic patients: a real clinical practice case-control study

Tassone Francesco , Ferreri Cinzia , Rossi Arianna , Baffoni Claudia , Borretta Giorgio , Feola Mauro

Background: Sodium-glucose cotransporter-2 (SGLT2) inhibitors demonstrated beneficial effects on cardiovascular and renal events in patients with type 2 diabetes mellitus. The mechanisms underlying these effects are not fully elucidated. Aim of this study was to investigate whether empagliflozin is able to affect arterial stiffness/pulse wave velocity in type 2 diabetic patients.Methods: Pulse wave velocity and other parameters of arterial stiffness were...

ea0049ep268 | Calcium & Vitamin D metabolism | ECE2017

Gender difference in clinical presentation of primary hyperparathyroidism

Gianotti Laura , Castellano Elena , Tassone Francesco , Baffoni Claudia , Cesario Flora , Magro Gianpaolo , Pellegrino Micaela , Borretta Giorgio

Objective: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders, with a female to male ratio of 3:1. Currently most patients with PHPT are asymptomatic. However, data about the gender impact on the clinical presentation of PHPT are lacking.Methods: We evaluated the difference in symptoms and biochemical parameters between men and women with PHPT in a single center series of 417 patients.Results: Male PHP...

ea0032p129 | Calcium and Vitamin D metabolism | ECE2013

Does recognition of vitamin D deficiency affect the indication for surgical treatment in asymptomatic primary hyperparathyroidism?

Gianotti Laura , Tassone Francesco , Pellegrino Micaela , Baffoni Claudia , Cassibba Sara , Magro Gianpaolo , Cesario Flora , Borretta Giorgio

Introduction: Current guidelines for the management of asymptomatic primary hyperparathyroidism (A-pHPT) recommend that 25-hydroxyvitamin D levels should be assessed in all patients and vitamin D deficiency (VDD) should be cautiously corrected. It is unknown whether VDD affects the probability to meet surgical criteria currently proposed for A-pHPT. Aim of study was to evaluate whether VDD recognition affects the probability to meet surgical criteria in A-pHPT patients.<p ...

ea0022oc6.2 | Bone | ECE2010

Association between serum osteocalcin and insulin sensitivity in primary hyperparathyroidism

Gianotti Laura , Tassone Francesco , Pellegrino Micaela , Baffoni Claudia , Croce Chiara Giulia , Cesario Flora , Borretta Giorgio

A regulatory role of the skeleton on glucose metabolism has been supposed both in animals and in humans. Osteocalcin (OC) seems to be involved in this regulation and has been reported to be inversely associated with insulin resistance and measures of adiposity in different populations of adult subjects. Primary hyperparathyroidism (PHPT) is a condition mostly affecting elderly subjects and characterized by both marked increased bone turnover and increased insulin resistance. T...

ea0020p230 | Bone/Calcium | ECE2009

Bone mineral density among patients with primary hyperparathyroidism with or without diabetes

Tassone Francesco , Gianotti Laura , Pellegrino Micaela , Baffoni Claudia , Ghio Michela , Emmolo Ignazio , Borretta Giorgio

Introduction: The relationship between diabetes mellitus (DM) and osteoporosis is controversial. Both Type 1 DM and Type 2 DM have been associated with higher risk of fractures, whereas BMD is increased in Type 2 and decreased in Type 1 DM. In primary hyperparathyroidism (PHPT) a higher prevalence of Type 2 DM has been found but the influence of DM on BMD is unknown.Subjects and methods: In a consecutive series of 262 patients with PHPT (age, mean±S...

ea0016p81 | Bone and calcium | ECE2008

Predictors of bone mineral density in men with primary hyperparathyroidism

Tassone Francesco , Gianotti Laura , Pellegrino Micaela , Croce Chiara , Baffoni Claudia , Magro Gianpaolo , Cesario Flora , Borretta Giorgio

Introduction: In primary hyperparathyroidism (PHPT) bone involvement is frequent. In women with PHPT it has been previously reported that menopausal status together with PTH, calcium levels and renal function are independent predictors of bone density. In male subjects, the impact of PHPT on bone status is less defined.Aim of the study: To investigate this study was possible predictors of bone mineral density (BMD) in a series of male subjects affected b...

ea0056p1032 | Thyroid (non-cancer) | ECE2018

Thyroid disease in PHPT: a single centre study

Castellano Elena , Gianotti Laura , Latina Adele , Cesario Flora , Baffoni Claudia , Pellegrino Micaela , Tassone Francesco , Magro Giampaolo , Borretta Giorgio

Objective: Primary hyperparathyroidism (PHPT) and thyroid diseases are common in the general population. It is difficult to establish whether they occur in the same patient because of a direct relationship or just due to the widespread prevalence of both conditions. The reported prevalence of the concomitant occurrence of these two clinical conditions is widely scattered (ranging 17–84%), especially due to the heterogeneous criteria for patient selection. We aimed to eval...