Endocrine Abstracts

Introduction: Von Hippel–Lindau (VHL) disease is a rare disorder, characterized by the development of a variety of benign and malignant tumors. It is autosomal dominantly inherited disease that causes retinal or central nervous system hemangioblastomas, endolymphatic sac tumors, renal cell carcinomas, pancreatic cysts and tumors, pheochromocytoma and epididymal cystadenomas. The condition is associated with inactivation of a tumor suppression gene.C...

Introduction: Grave’s disease is frequently associated with cytopenia. Pancytopenia, however, is rare. Thyroid hormones have a direct effect on myocardial contractility and left ventricle (LV) diastolic function. Only less than 1% of the patients with hyperthyroidism develop cardiomyopathy with impaired left ventricular systolic function.Case: A 51-year old woman was admitted to the Hospital of Lithuanian University of Health Sciences, Kaunas clinic...

Adult patients with acromegaly after pituitary adenomas usually have emotional problems, impaired quality of life. Objective was to detect possible differences of emotional state between patients with acromegaly after pituitary adenomas and healthy age- and sex-matched controls and to outline possible gender-specific differences.Patients and methods: 12 males (age 49.6±10.2 years) and 29 females (age 51.5±9.5 years) with acromegaly after pituit...

Introduction: Hypothyroidism is associated with a spectrum of symptoms affecting almost all bodily functions. We present a case of severe hypothyroidism with multiple body cavity effusions, volvulus of sigma creating ileus.Case report: A 70 year old female was admitted to emergency department with dyspnea, and acute abdominal pain. Physical examination was notable for anasarca, abdominal fluid wave, lower extremity pitting edema, hypotension. She did not...

Introduction: Tumor-induced osteomalacia (TIO) or oncogenic hypophosphatemic osteomalacia (OHO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting leading to hypophosphatemia and secondary osteomalacia. TIO was first described in 1947 by Robert McCance and only 500 of cases have been reported in literature since then, approximately 200 of cases during this decade.Case report: In 2014, a 32-year-old female presented with waist pain...

Introduction: Ectopic adrenocorticotropic hormone (ACTH) production by the pulmonary neuroendocrine tumour (p-NET) is rare, and is considered an aggressive variant of carcinoid tumours with poor prognosis.Case presentation: 59-year-old male with fast progressing generalized fatigue, abdominal discomfort, and diarrhea was hospitalized in gastroenterology unit of Hospital of Lithuanian University of Health Sciences, Kauno klinikos (HLUHS KK). Digestive tra...

Introduction: ACTH producing macroadenoma and pituitary apoplexy are rare in Cushing’s disease. Somatostatin receptor agonist Pasireotide is indicated for the treatment of patients with Cushing’s disease for whom surgery is not an option or has failed. We present a case of pituitary apoplexy in patient with recurrence of Cushing’s disease treated with Pasireotide.Case: 38 years old female presented with quick weight gain, weakness, irregul...

Anaplastic thyroid carcinoma (ATC) is a rare form of thyroid carcinoma that is associated with an extremely poor prognosis. Ultrasonography (US) and subsequent fine needle aspiration biopsy (FNAB) are the first diagnostic methods in the assessment of a palpable thyroid mass. Nevertheless, some clinical and US features of ATC are not specific. Here, we report on an extremely rare case of ATC masquerading as subacute thyroiditis (SAT).A 40-year-old woman w...

Introduction: Phaeochromocytoma in pregnancy is very rare and potentially dangerous situation for mother and foetus. Failure to diagnose this condition or suboptimal management can be disastrous for mother and/or foetus, because of raised catecholamine levels.Case: A 22-year-old pregnant woman (8 weeks’ gestation) with hypertension and a suspected recurrence of phaeochromocytoma was referred to the Endocrinology Department in March 2014. The pregnan...

Adrenal incidentaloma is adrenal tumor incidentally discovered in the region of adrenals, usually investigating for non-endocrine disease.We attempted to find out the current situation of adrenal incidentaloma in Lithuania.The object of research – patients who visited the Lithuanian University of Health Sciences, Kaunas Clinic's Clinic of Endocrinology and Vilnius Endocrinology Center for suspected adrenal pathology in 2007–2011. The total numb...