Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep175 | Endocrine tumours and neoplasia | ECE2017

Follow-up in neuroendocrine tumors: is chromogranin A the confounder?

Martins Diana , Baptista Carla , Velez Ana , Macario Fernando , Carrilho Francisco

Introduction: Chromogranin A continues to be one of the most valuable markers for neuroendocrine tumors (NETs) however, it has several limitations, including its reduced specificity.Methods: The authors present the case of a patient diagnosed with a midgut NET, during follow-up.Results: Male patient, 61 years old, with chronic renal disease (CRD), underwent right hemicolectomy owing to ileo-cecal valve lesion; hist...

ea0063p1195 | Thyroid 3 | ECE2019

Amiodarone-induced thyrotoxicosis: when combined treatment is an option

Silva Diana , Ruas Luisa , Cunha Nelson , Catarino Diana , Fadiga Lucia , Guiomar Joana , Carrilho Francisco

Introduction: Amiodarone is an effective drug in the management of supraventricular arrhythmias. Due to its composition rich in iodine and pharmacological properties can cause thyroid dysfunction in 15–20% of the treated patients. Clinically it can present in the form of amiodarone-induced hypothyroidism or amiodarone-induced thyrotoxicosis. This latter situation may result from an excess of iodine supply, glandular destruction or both pathogenic mechanisms.<p class="...

ea0049gp35 | Bone &amp; Calcium Homeostasis 1 | ECE2017

Aldosterone and parathyroid hormone – is there a connection?

Ventura Mara , Melo Miguel , Oliveira Diana , Martins Diana , Lages Adriana , Cunha Nelson , Carrilho Francisco

Introduction: Recent studies seem to support a bidirectional positive interaction between aldosterone and parathyroid hormone (PTH). Understanding the normal physiological relationship between renin-angiotensin-aldosterone system (RAAS) and PTH is of clinical interest because their inappropriate activity may negatively impact cardiovascular and skeletal health.Objective: To evaluate the presence of an interaction between aldosterone and PTH in a cohort o...

ea0049ep61 | Adrenal cortex (to include Cushing's) | ECE2017

Autoimmune Addison disease – data from long-term follow-up of patients from a tertiary hospital’s Endocrinology Department

Oliveira Diana , Paiva Isabel , Lages Adriana , Martins Diana , Ventura Mara , Cunha Nelson , Paiva Sandra , Carrilho Francisco

Introduction: Autoimmune Addison disease requires lifelong glucocorticoid and mineralocorticoid replacement. Optimal therapy is not standardized and must balance adequate hormone substitution with prevention of treatment-related complications.Objective: Assessment of patients followed at our department: epidemiology, associated conditions, treatment, cumulative hydrocortisone dose and comorbidities.Methods: Review of clinical recor...

ea0049ep922 | Paediatric endocrinology | ECE2017

Endocrine manifestations of multisystem Langerhans cell histiocytosis

Oliveira Diana , Napoli Flavia , Bertelli Enrica , Maggioni Alessandra , Paiva Sandra , Carrilho Francisco , Iorgi Natascia Di

Introduction: Multisystem Langerhans cell histiocytosis (LCH) is a rare heterogeneous disorder caused by accumulation in multiple organs of dendritic cells phenotypically similar to cutaneous Langerhans cells. Pituitary involvement is present in about 25% of cases, and central diabetes insipidus is the most common deficit in that setting. Panhypopituitarism is rare, but hypothalamic-pituitary dysfunction is amongst the most frequent long-term complications of the disease.<...

ea0041ep818 | Obesity | ECE2016

Metabolically healthy obesity: exploring the paradox

Ventura Mara , Lages Adriana , Rodrigues Dircea , Oliveira Patricia , Melo Miguel , Martins Diana , Oliveira Diana , Carrilho Francisco

Introduction: Obesity is a chronic disease associated with multiple comorbidities, defined by BMI, without considering the metabolic state of the patient. There are few data on the proportion of obese patients without metabolic syndrome (MS).Objective: To characterize patients considered to be metabolically healthy (MH) followed at the obesity outpatient clinic of one University Hospital, and to compare this group with a group of obese patients with MS.<...

ea0041ep985 | Thyroid (non-cancer) | ECE2016

Clinical, imaging and cytological differences between palpable and non-palpable thyroid nodules

Silva Joao , Paiva Sandra , Ribeiro Cristina , Melo Miguel , Gomes Leonor , Bastos Margarida , Carrilho Francisco

Introduction: The prevalence of palpable nodules varies between 3–7% and nodules diagnosed by ultrasonography between 20–76%. According to the American Thyroid Association’s guidelines it isn’t recommended to perform routine thyroid ultrasound for thyroid nodules diagnosis, unless they are palpable or there are any risk factors.Objective: Evaluation of sonographic and cytological differences between palpable and non-palpable thyroid n...

ea0037gp.22.03 | Pituitary–Therapy of Cushing's disease | ECE2015

Impact of preoperative magnetic resonance in surgical care of patients with Cushing's disease

Guelho Daniela , Martins Diana , Paiva Isabel , Cardoso Luis , Vicente Nuno , Oliveira Diana , Balsa Margarida , Carrilho Francisco

Introduction: Cushing’s disease (CD) is a rare disorder caused by an ACTH-secreting pituitary adenoma. Transsphenoidal surgery (TSS) is the recommended first-line treatment. However, an equivocal or even normal preoperative MRI can preclude the surgical management and the outcome of these patients.Objectives: Evaluate the relationship between preoperative MRI and TSS efficacy in patients with CD.Methods: Retrospective cohort s...

ea0037ep512 | Diabetes (complications &amp; therapy) | ECE2015

Continuous subcutaneous insulin infusion decreases hypoglycaemia during nighttime

Vicente Nuno , Cardoso Luis , Baptista Carla , Barros Luisa , Guelho Daniela , Oliveira Diana , Martins Diana , Carrilho Francisco

Introduction: Continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) are forms of intensified insulin therapy and the most used regimens for type 1 diabetes (T1D). Owing to its continuous basal output, hypoglycaemic events tend to be rarer with CSII. Our goal was to evaluate the differences in nocturnal hypoglycemia between these two treatment strategies.Methods: Retrospective analysis of 61 patients who had performed continu...

ea0035p328 | Clinical case reports Thyroid/Others | ECE2014

Gynecomastia: a rare etiology

Vicente Nuno , Barros Luisa , Saraiva Joana , Moreno Carolina , Guelho Daniela , Cardoso Luis , Carrilho Francisco

Introduction: Gynecomastia is a frequent reason for endocrinology consultation and its correct investigation is pivotal towards a precise diagnosis. We present a clinical case of a rare cause of gynecomastia.Case report: A 56-year-old male was referred to the hospital setting for an endocrinology consultation. He noticed increased breast size for a year, initially tender to palpation, and unquantified weight loss. Neither galactorrhea, nor any nipple dis...