Searchable abstracts of presentations at key conferences in endocrinology

ea0035p712 | Neuroendocrinology | ECE2014

Papillary thyroid carcinoma associated with silent paraganglioma: An atypical MEN syndrome?

Tarcin Ozlem , Yazici Dilek , Unal Asli , Demirag Nilgun Guvener

Case: A 51-year-old-woman was referred to endocrinology outpatient clinic due to a thyroid nodule 9 mm in diameter. Fine needle aspiration (FNA) biopsy revealed papillary thyroid carcinoma and she was directed to surgery. The surgeon decided to perform subtotal thyroidectomy due to the small nodule size. Pathologic examination showed the histology to be consistent with tall cell carcinoma. Complementary total thyroidectomy was proposed to the patient but she did not accept the...

ea0022p364 | Diabetes | ECE2010

Evaluating the effects of vitamin D metabolism on glycemic parameters and atherosclerosis markers in prediabetic patients

Parildar Hulya , Takir Mumtaz , Unal Asli Dogruk , Cigerli Ozlem , Gulmez Oyku , Dinc Feyza , Guvener Nilgun Demirag

Background and aims: Hypovitaminosis D may be associated with metabolic parameters in addition to its well-known calcemic actions. There is increasing evidence that vitamin D metabolism affects the risk of insulin resistance although the underlying molecular mechanism of this association is not clear but on the basis of evidence it is not clear whether or not vitamin D supplementation therapy in vitamin D-deficient prediabetics affects the prevention of type 2 diabetes. Our st...

ea0022p367 | Diabetes | ECE2010

Evaluation of HbA1c levels for the detection of prediabetes

Unal Asli Dogruk , Parildar Hulya , Takir Mumtaz , Cigerli Ozlem , Dinc Feyza , Guvener Nilgun Demirag

Objective: Recent recommendations suggest that HbA1c as a stable and standardised index of chronic glucose exposure over time and could be used as a better biochemical marker for the diagnosis of diabetes and prediabetes. Our aim in this cross-sectional study is to assess the validity of HbA1c as a screening tool for the detection of prediabetes in our patient population.Methods: The study was done in 265 patients selected among the participants attended...

ea0035oc4.3 | Diabetes and Obesity 1 | ECE2014

Importance of neuropeptide Y as a predictor of nephropathy in type 2 diabetic patients

Unal Asli Dogruk , Tarcin Ozlem , Takir Mumtaz , Parildar Hulya , Cigerli Ozlem , Eroglu Hacer , Demirag Nilgun Guvener

Background and aims: Neuropeptide Y (NPY) cause decrease glomerular filtration rate, aldosterone concentration, and plasma renin activity by stimulating NPY receptors in the kidney. Previous studies have suggested that NPY polymorphism is related to development of advanced diabetic nephropathy (DN). The aim of this study was to evaluate the relationship between the serum neuropeptide Y levels and different stages of DN in patients with type 2 diabetes mellitus (T2DM).<p cl...

ea0032p608 | Female reproduction | ECE2013

Vitamin D level in polycystic ovary syndrome patients is not different from healthy control in Turkish population

Unal Asli Dogruk , Tarcin Ozlem , Cigerli Ozlem , Takir Mumtaz , Parildar Hulya , Ergen Nilay , Demirag Nilgun Guvener

Introduction: Polycystic ovary syndrome (PCOS) is widely diagnosed among young women in reproductive age. Vitamin D deficiency has been known as a common problem in all ages and also in a recent study which performed in a small study groups, reported that it may accompany with hyperandrogenism. The aim of our study is to evaluate serum 25(OH)D3 levels in PCOS patients compared with healthy control and relation to androgen levels.Methods: Forty...

ea0016p52 | Adrenal | ECE2008

Relation between serum adiponectin level, subclinical Cushing's syndrome and non-functional adrenal incidentaloma

Unal Asli Dogruk , Ayturk Semra , Kemal Yasemin , Tutuncu Neslihan Bascil , Demirag Nilgun Guvener

In this study we compared plasma adiponectin levels between patients with non-functional adrenal incidentaloma and subclinical Cushing’s syndrome. Our aims were to determine whether there was any difference of plasma adiponectin levels, any relation between cardiovasculer risk factors and to investigate the importance of adiponectin levels in subclinical Cushing’s syndrome patients according to non-functional adrenal incidentaloma patients. The patients referred from...

ea0016p113 | Clinical cases | ECE2008

Unresectable huge sternal and mediastinal metastasis of follicular thyroid carcinoma; radiotherapy as first-line and palliative therapy

Demirer Asli Nar , Ayturk Semra , Tutuncu Neslihan Bascil , Gursoy Alptekin , Pak Yucel , Demirag Nilgun Guvener

Distant metastases as initial manifestation of follicular thyroid carcinoma is rare. We report a case of an unusual initial presentation of follicular thyroid carcinoma on follow-up. A 52-year-old woman presented with a 12-month history of progressively enlarging mass in the anterior chest wall. The mass was fixed to the chest wall, measuring 12×10 cm in diameter. Computed tomography demonstrated a lobulated soft-tissue mass (17×11×6 cm) destructing sternum and ...

ea0016p392 | Neuroendocrinology | ECE2008

Macroprolactinemia seems to have a positive effect on platelet activation through ADP stimulation

Anaforoglu Inan , Ertorer Eda , Kozanoglu Ilknur , Unal Birsel , Haydardedeoglu Filiz , Tutuncu Neslihan Bascil , Demirag Nilgun Guvener

Objective: Platelet activation is a recently recognized characteristic of prolactin, which functions through the potentiation of ADP-induced P-selectin expression on platelets. Studies in hyperprolactinemic patients demonstrated atherosclerotic disorders related to insulin resistance; convenient milieus for platelet activation. To investigate the association between hyperprolactinemia and platelet activation related to P-selectin expression, we studied on hyperprolactinemic an...

ea0016p690 | Thyroid | ECE2008

Clinicopathological characteristics of thyroid cancer in patients on dialysis for end-stage renal disease

Demirer Asli Nar , Kemal Yasemin , Tutuncu Neslihan Bascil , Gursoy Alptekin , Demirag Nilgun Guvener

Objective: Our aim was to determine the prevalence and clinicopathological characteristics of thyroid cancers in the dialysis population and to evaluate potential risk factors.Design: We performed a retrospective analysis of our end-stage renal disease (ESRD) patients on dialysis and thyroidectomized patients without ESRD (2000–2006). Then we compared the data of thyroid cancer patients on dialysis (n=9) with the data of patients who had hist...

ea0016p694 | Thyroid | ECE2008

Cyclin A and B1 are overexpressed in thyroid cancers which had been operated for indeterminate, nondiagnostic, or suspicious fine-needle aspirate results

Demirer Asli Nar , Ozen Ozlem , Sengul Aysegul , Tutuncu Neslihan Bascil , Gursoy Alptekin , Demirag Nilgun Guvener

Objective: Approximately 30% of patients with thyroid nodules have indeterminate, nondiagnostic, or suspicious fine-needle aspiration (FNA) biopsy results. These patients usually undergo thyroidectomy because of cancer risk. Our aim was to determine diagnostic markers to distinguish benign from malignant thyroid neoplasms, so we focused on G2-M boundary regulators of the cell cycle and investigated the expression of two proteins, cyclin A and cyclin B1.M...