Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep12 | Adrenal cortex (to include Cushing's) | ECE2016

Nonfunctional adrenal incidentalomas and cardiometabolic risk

Ferreira Lia , Palma Isabel

Background: Incidentally discovered adrenal tumours have become a common clinical problem. The presence of an adrenal incidentalomas has been associated with an increase incidence of several cardiovascular risk factors. These abnormalities are more frequent in patients with clinical and subclinical hypercortisolism, nevertheless some studies have reported an association between nonfunctioning adrenal incidentalomas (NFAIs) with increased insulin resistance and cardiovascular r...

ea0056p63 | Adrenal cortex (to include Cushing's) | ECE2018

Salivary cortisol as a diagnostic tool for hypercortisolism in Cushing’s syndrome and adrenal incidentaloma

Ferreira Lia , Amaral Claudia , Palma Isabel , Cardoso Helena

Background: The lack of circadian rhythm is a marker of Cushing’s syndrome (CS). Therefore, salivary cortisol rhythm has been suggested for studies on the hypothalamic–pituitary–adrenal (HPA) axis. Late-night salivary cortisol has been used recently by many centers as a first line diagnostic test for CS, yet its accuracy is still on debate.Aim: To evaluated the performance of morning and late night salivary cortisol in patients with CS and...

ea0049ep350 | Endocrine tumours and neoplasia | ECE2017

A suspicious case of multiple endocrine neoplasia

Pereira Teresa Alves , Furtado Ines , Amado Ana , Ferreira Lia , Almeida Raquel , Palma Isabel

Introduction: Multiple endocrine neoplasia (MEN) syndromes are rare entities characterized by the occurrence of tumors involving two or more endocrine glands in a single patient. These syndromes are classified as type 1 or 2 according to specific phenotypic characteristics. MEN2 encompasses three different subtypes: MEN2A, MEN2B and familial medullary thyroid carcinoma. More recently a syndrome related to mutations in the CDKN1B gene has been described – the syndrome of m...

ea0037ep552 | Obesity and cardiovascular endocrinology | ECE2015

Influence of normal food intake on the lipid profile of diabetic patients

Garrido Susana , Almeida Raquel , Pereira Teresa , Ferreira Lia , Neto Helena , Vilaverde Joana , Pichel Fernando , Oliveira Jose Carlos , Palma Isabel

Introduction: The need to fast for the determination of lipid profile has been discussed in the past years, for several reasons – i) most of the day time is spent in a postprandial state; ii) the lipid concentrations seem to be only slightly affected by a normal meal; both fasting and postprandial can predict cardiovascular risk.Aim: Determine the influence of normal food intake on the lipid profile of diabetic patients.Method...

ea0056p719 | Clinical case reports - Pituitary/Adrenal | ECE2018

From adrenal incidentalomas to Cushing’s disease

Alves Pereira Teresa , Ferreira Lia , Furtado Ines , Lopes Ana , Fonseca Liliana , Amaral Claudia , Palma Isabel , Cardoso Helena

Introduction: Adrenal incidentalomas are asymptomatic adrenal masses found accidentally during routine examination, not intended for adrenal pathology evaluation. The functionality of these lesions must be further investigated. Rarely, bilateral adrenal nodular hyperplasia can be detected in a patient with Cushing’s disease. The authors present the case of a patient with possible autonomous cortisol secretion of adrenal origin that eventually emerged as Cushing’s dis...

ea0056ep15 | Adrenal and Neuroendocrine Tumours | ECE2018

IGF-2-oma: a diagnosis to be considered in a patient with a leiomyosarcoma and recurrent hypoglycemia

Fonseca Liliana , Ferreira Lia , Pereira Teresa Alves , Lopes Ana , Almeida Raquel , Vilaverde Joana , Pereira Maria Teresa , Cardoso Helena

Introduction: Non-islet cell tumor induced hypoglycemia (NICTH) is a paraneoplastic phenomenon involving many types of tumors. It is associated with the secretion of incompletely processed precursors of IGF-2 resulting in a persistent insulin-like activity and hypoglycemia. Most commonly, IGF-2–linked hypoglycemia has been observed in patients with solid mesenchymal or epithelial tumors. Typically, elevated IGF-2 levels are associated with suppressed plasma levels of insu...

ea0081p316 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Simultaneous pancreas-kidney transplantation: long-term survival and metabolic profile analysis among functioning pancreatic graft patients – A 20 year experience from a center in Portugal

Maia Ariana , Saraiva Miguel , Sala Ines , Soares Daniela , Borges Soares Diana , Monteiro Silvia , Vilaverde Joana , Ferreira Lia , Martins La Salete , Dores Jorge

Introduction: Simultaneous pancreas-kidney transplantation (SPKT) is the treatment of choice for type 1 diabetic patients with advanced kidney chronic disease (CKD), restoring normoglycemia, insulin independence and improving survival. The present study aims to analyse survival of patients undergoing SPKT and the post-SPKT metabolic profile of patients with a functioning pancreatic graft.Methods: Retrospective observational study. T1DM patients with CKD ...

ea0037ep311 | Calcium and Vitamin D metabolism | ECE2015

Primary hyperparathyroidism presented as humeral brown tumor and multiple bone fractures

Ferreira Lia , Gomes Pedro , Cardoso Pedro , Valente Vitor , Amado Ana , Pereira Maria Teresa , Garrido Susana , Almeida Raquel , Freitas Claudia , Amaral Claudia , Palma Isabel , Borges Fatima

Primary hyperparathyroidism (PHPT) is frequently diagnosed as an incidental finding of hypercalcemia. Overt bone disease (osteitis fibrosa cystica or brown tumor), with history of pathologic fractures is a rare presentation.A 48-year-old woman was admitted in with pain in the right thigh after a trivial fall. She also complained of generalized weakness and lethargy over the last 2 years. Her medical history mention multiple bone fractures in the last 6 y...

ea0049ep57 | Adrenal cortex (to include Cushing's) | ECE2017

Primary adrenal insufficiency: a Portuguese multicentre study by the adrenal tumour study group

Ferreira Lia , Silva Joao , Martins Ana , Belo Carlos , Oliveira Diana , Simoes Helder , Paiva Isabel , Guimaraes Joana , Ferreira Marta , Silva Rita , Garrido Susana , Silva Tiago , Fernandes Vera , Pereira Maria Lopes

Introduction: Primary adrenal insufficiency (PAI) is a rare but severe and potentially life-threatening condition. There are no studies characterizing portuguese patients with PAI.Aims: To characterize the clinical presentation, diagnostic workup, treatment and follow-up of patients with confirmed PAI.Methods: A multicentre retrospective study of PAI patients followed in 12 portuguese hospitals.Results: We in...

ea0073aep398 | Endocrine-Related Cancer | ECE2021

Clinical presentation, phenotype, and germline variants of pheochromocytoma and paraganglioma: A three-decade clinical experience

Duarte Diana Borges , Saraiva Miguel , Ferreira Marta Almeida , Ferreira Lia , Pereira Maria Teresa , André Carvalho , Cláudia Amaral , Vilaverde Joana , Cláudia Freitas , Dores Jorge , Carvalho Rui , Palma Isabel

IntroductionPheochromocytomas are rare catecholamine-producing neuroendocrine tumours arising from chromaffin cells of the adrenal medulla or extra-adrenal sympathetic paraganglia(paragangliomas).AimTo characterise demographic, clinical, and biochemical/genetic features of a cohort of patients with pheochromocytoma and paraganglioma (PPGL), assessing for differences between two-time periods over a three-decad...