Searchable abstracts of presentations at key conferences in endocrinology

ea0035p162 | Calcium and Vitamin D metabolism | ECE2014

Hypocalcemia caused by type 1b pseudohypoparathyroidism

Oliveira Joana , Freitas Paula , Carvalho Davide

Introduction: The pseudohypoparathyroidism (PHP) encompasses a heterogeneous group of diseases characterized by end-organ resistance to parathyroid hormone (PTH). PHB type 1b (PHP1b) presents with PTH resistance at the renal proximal tubule, sometimes with TSH resistance, usually in the absence of Albright’s hereditary osteodystrophy (AHO) clinical features.Case report: A 64-year-old male was referred to endocrinology department for hypocalcemia. He...

ea0081ep602 | Endocrine-Related Cancer | ECE2022

Ectopic Cushing's syndrome due to metastatic lung carcinoid presenting on a background of DIPNECH

Moreno Telma , Ribeiro Sara , Varela Ana , Freitas Paula , Carvalho Davide

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a relatively recent and rare disease, frequently misdiagnosed. It is characterized as a generalized proliferation of pulmonary neuroendocrine cells and is recognized as a precursor lesion for pulmonary neuroendocrine tumors, although the risk of progression to malignancy is considered low. Here we report a patient with ectopic ACTH-dependent Cushing’s syndrome due to metastatic lung carcinoid tumors...

ea0090p784 | Thyroid | ECE2023

Methimazole induced agranulocytosis - A clinical case report

Menino Joao , Meira Ines , Pedro Jorge , Carvalho Davide , Freitas Paula

Introduction: Antithyroid drugs (ATDs) are generally safe and well tolerated, however, major side effects such as hepatotoxicity and agranulocytosis may occur and patients should be provided information on the major symptoms of these conditions. Although rare, agranulocytosis appears to be more likely with propylthiouracil (PTU) at any dose than with low-dose Methimazole (MMI). Clinical Case: We describe the case of a 70-year-old woman referred to Endocr...

ea0090ep809 | Pituitary and Neuroendocrinology | ECE2023

The importance of Prompt Treatment of Ectopic Cushing Syndrome

Meira Ines , Menino Joao , Pedro Jorge , Carvalho Davide , Freitas Paula

Introduction: Ectopic ACTH production accounts for up to 20 percent of ACTH-dependent Cushing syndrome (CS). Small cell carcinoma and carcinoid of the lung represents half of its cases. These patients lack some of the more obvious clinical features of cortisol excess. Therefore, this can cause a delay in the diagnosis of CS and these patients may be at high risk of life-threatening complications such as infections or thrombosis.Clinical case: Case of a 7...

ea0032p894 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Familiar panhypopituitarism by a mutation in PROP1: four of seven brothers affected

Lau Eva , Freitas Paula , Coutinho Eduarda , Lemos Manuel , Carvalho Davide

Introduction: Generously supported by IPSEN)-->PROP1 (Prophet of Pit-1) mutations are the most frequent genetic cause of panhypopituitarism, a condition associated with a deficiency or inadequate production of hormones of the anterior pituitary. The PROP1 gene encodes a transcription factor involved in the ontogeny, differentiation and function of somatotrophs, lactotrophs and thyrotrophs. These mutations are characterized by a remar...

ea0090rc11.5 | Rapid Communications 11: Late Breaking | ECE2023

Pregnancy after bariatric surgery – Experience from a tertiary hospital

Urbano Ferreira Helena , von Hafe Madalena , Dias Helena , Goncalves Juliana , Rodrigues Teresa , Belo Sandra , Freitas Paula

Introduction: Maternal obesity is associated with an increased risk of gestational diabetes, large for gestational age (LGA) newborns, preterm delivery, congenital malformations, and fetal death. On the other hand, bariatric surgery before pregnancy is associated with a reduction of obesity-associated complications, but also with an increased risk of small for gestational age (SGA) newborns, fetal growth restriction and micronutrient deficiencies during pregnancy.<p class=...

ea0090ep64 | Adrenal and Cardiovascular Endocrinology | ECE2023

Cushing’s Syndrome due Primary bilateral macronodular adrenal hyperplasia–a case series from a tertiary hospital

Goncalves Juliana , Ferreira Helena Urbano , Pedro Jorge , Carvalho Davide , Freitas Paula

Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing’s syndrome (CS). It is a highly heterogeneous disease with multiple adrenal macronodules and variable levels of cortisol excess. The pathogenesis is complex and different mechanisms such as aberrant hormone receptors, local production of ACTH in adrenal tissues and genetic mutations have been identified. The approach is not well established. Nine patients with PBMAH who are currently fol...

ea0090ep82 | Adrenal and Cardiovascular Endocrinology | ECE2023

Black adrenal adenoma mimicking an oncocytoma–a case report

Urbano Ferreira Helena , Goncalves Juliana , Belo Sandra , Carvalho Davide , Freitas Paula

Introduction: Black adrenal adenomas are rare and benign. They are named after their black appearance, due to lipofuscin pigment. Most frequently black adenomas are associated with ACTH-independent Cushing’s syndrome. They can also cause primary hyperaldosteronism or be nonfunctioning. Unlike most other adrenal adenomas, black adenomas exhibit high Hounsfield units (>30) on CT, and high standard uptake value on FDG-PET.Case presentation: A 67-ye...

ea0090ep717 | Pituitary and Neuroendocrinology | ECE2023

Bilateral petrosal sinus sampling – a 15-year experience from a tertiary hospital

Ferreira Helena Urbano , Goncalves Juliana , Belo Sandra , Alves Goncalo , Silva Maria Luis , Carvalho Davide , Freitas Paula

Introduction: In patients with ACTH-dependent Cushing Syndrome, differentiating between pituitary and ectopic sources can be challenging. Noninvasive testing can be performed, but bilateral inferior petrosal sinus sampling (BIPSS) remains the gold standard. In the last years however, novel imaging modalities, namely 3T-MRI with 3-dimensional spoiled gradient-echo sequence and 68Ga-tagged CRH combined with positron emission tomography, have been proposed as alternatives.<p ...

ea0063p186 | Diabetes, Obesity and Metabolism 1 | ECE2019

Relationship between cortisoluria and the presence of metabolic syndrome among HIV-infected patients

Guerreiro Vanessa , Sergio Joao , Serrao Rosario , Sarmento Antonio , Carvalho Davide , Freitas Paula

Introduction: People living with human immunodeficiency virus (HIV) are at increased risk of developing metabolic disorders, such as obesity, dyslipidemia, insulin resistance, diabetes and hypertension; which may also be associated with hypercortisolism. Due to the similarity between the metabolic changes present in these two clinical situations, several studies have evaluated whether HIV-infected patients have increased levels of cortisol, but the results are not consensual. ...