Searchable abstracts of presentations at key conferences in endocrinology

ea0035p162 | Calcium and Vitamin D metabolism | ECE2014

Hypocalcemia caused by type 1b pseudohypoparathyroidism

Oliveira Joana , Freitas Paula , Carvalho Davide

Introduction: The pseudohypoparathyroidism (PHP) encompasses a heterogeneous group of diseases characterized by end-organ resistance to parathyroid hormone (PTH). PHB type 1b (PHP1b) presents with PTH resistance at the renal proximal tubule, sometimes with TSH resistance, usually in the absence of Albright’s hereditary osteodystrophy (AHO) clinical features.Case report: A 64-year-old male was referred to endocrinology department for hypocalcemia. He...

ea0081ep602 | Endocrine-Related Cancer | ECE2022

Ectopic Cushing's syndrome due to metastatic lung carcinoid presenting on a background of DIPNECH

Moreno Telma , Ribeiro Sara , Varela Ana , Freitas Paula , Carvalho Davide

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a relatively recent and rare disease, frequently misdiagnosed. It is characterized as a generalized proliferation of pulmonary neuroendocrine cells and is recognized as a precursor lesion for pulmonary neuroendocrine tumors, although the risk of progression to malignancy is considered low. Here we report a patient with ectopic ACTH-dependent Cushing’s syndrome due to metastatic lung carcinoid tumors...

ea0032p894 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Familiar panhypopituitarism by a mutation in PROP1: four of seven brothers affected

Lau Eva , Freitas Paula , Coutinho Eduarda , Lemos Manuel , Carvalho Davide

Introduction: Generously supported by IPSEN)-->PROP1 (Prophet of Pit-1) mutations are the most frequent genetic cause of panhypopituitarism, a condition associated with a deficiency or inadequate production of hormones of the anterior pituitary. The PROP1 gene encodes a transcription factor involved in the ontogeny, differentiation and function of somatotrophs, lactotrophs and thyrotrophs. These mutations are characterized by a remar...

ea0063p186 | Diabetes, Obesity and Metabolism 1 | ECE2019

Relationship between cortisoluria and the presence of metabolic syndrome among HIV-infected patients

Guerreiro Vanessa , Sergio Joao , Serrao Rosario , Sarmento Antonio , Carvalho Davide , Freitas Paula

Introduction: People living with human immunodeficiency virus (HIV) are at increased risk of developing metabolic disorders, such as obesity, dyslipidemia, insulin resistance, diabetes and hypertension; which may also be associated with hypercortisolism. Due to the similarity between the metabolic changes present in these two clinical situations, several studies have evaluated whether HIV-infected patients have increased levels of cortisol, but the results are not consensual. ...

ea0049ep169 | Endocrine tumours and neoplasia | ECE2017

Respiratory symtoms lead to a diagnosis of pheochromocytoma: An unusual presentation

Teles Luis , Neves Joao Sergio , Souteiro Pedro , Oliveira Sofia Castro , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Pheochromocytoma is one of the major secondary causes of hypertension. The classic triad of pheochromocytoma symptoms of headache, sweating and tachycardia is not present in a high percentage of patients and is sometimes diagnosed as incidentaloma or atypical presentations.Case report: The authors present a 56-year-old man, with no known diseases, referred to Endocrinology evaluation by incidentaloma of the right adrenal gland, from the Pne...

ea0049ep493 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Bronze diabetes – a rare secondary cause of diabetes

Souteiro Pedro , Neves Joao Sergio , Oliveira Sofia Castro , Belo Sandra , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Secondary causes of diabetes refer to a category in which diabetes is associated with other diseases. They are thought to constitute less than 2% of the total cases of diabetes.Case report: A 56 year-old caucasian man, with no relevant medical history, presented to the Emergency Department with fatigue, polyuria, polydipsia, polyphagia and involuntary weight loss (6 kg in two weeks). He was hemodynamically stable and exhibited a glycaemia o...

ea0049ep1081 | Pituitary - Clinical | ECE2017

Hypopituitarism and central diabetes insipidus in an HIV patient – a late complication of cerebral toxoplasmosis and/or antiretrovirals?

Oliveira Sofia Castro , Souteiro Pedro , Neves Joao Sergio , Nogueira Claudia , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: The endocrine system is often affected in the course of HIV infection. However, hypopituitarism and diabetes insipidus are uncommon disorders in these patients and have been related to drugs, infections of the central nervous system and neoplastic infiltration, in extremely rare cases.Case report: We present a case of a 42-year-old man with HIV infection known since 2005, but undergoing antiretroviral therapy only since 2010 (emtricitabine/...

ea0041ep632 | Endocrine tumours and neoplasia | ECE2016

Evaluation of the incidence and clinical characteristics of glucose metabolism alterations during the follow-up of surgically treated insulinomas

Sergio Neves Joao , Lau Eva , Oliveira Joana , Isabel Oliveira Ana , Freitas Paula , Carvalho Davide

Introduction: The incidence of glucose metabolism alterations during the follow-up of surgically treated insulinomas is largely unknown. Our aim was to evaluate the incidence, and the clinical characteristics, of diabetes and prediabetes in this population.Methods: We retrospectively analyzed the cases diagnosed as insulinomas in a Central Hospital in Portugal in the period between January 1980 and December 2015.Results: We identif...

ea0040p16 | (1) | ESEBEC2016

Insulinomas at São João Hospital between 1980 and 2015

Neves Joao Sergio , Lau Eva , Oliveira Joana , Oliveira Ana Isabel , Freitas Paula , Carvalho Davide

Introduction: Insulinomas are pancreatic endocrine tumors originating in the beta cells, characterized by hypoglycemia resulting from insulin hypersecretion.Objectives: To characterize the demography, the clinical features, imagiological findings and pathological evaluation of the cases of insulinomas identified in the previous 35 years at São João Hospital.Methods: We retrospectively analyzed the cases diagnosed as insul...

ea0037ep641 | Obesity and cardiovascular endocrinology | ECE2015

Body composition in HIV-infected patients under combined antiretroviral therapy over 5 years

Grenha Ines , Oliveira Joana , Lau Eva , Vieira Romana , Serrao Rosario , Sarmento Antonio , Carvalho Davide , Freitas Paula

Introduction: HIV infection and combined antiretroviral therapy (cART) have been associated with lipodistrophy and changes in body composition. However, there are few studies on body composition evolution of HIV-infected patients, under cART.Aims: To evaluate the evolution of body composition in HIV-1 infected patients under cART over 5 years.Methods: Retrospective, observational study in a cohort of HIV-infected patients on cART. ...