Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep718 | Male Reproduction | ECE2016

Is Testosterone (T) treatment safe and effective in men with HIV infection? A meta-analysis

Santi Daniele , Guaraldi Giovanni , Corona Giovanni , Rochira Vincenzo

Background: Prevalence of hypogonadism is high (30%) in men with HIV. In these patients T treatment (TT) is currently used mainly to counteract wasting syndrome and/or HIV-related lipodystrophy, irrespective of patients’ serum T. However, its effect and safety in HIV-infected men is still not completely known.Aim: To investigate both beneficial and adverse effects related to TT in HIV-infected men using a meta-analytic approach.<p class="abstext...

ea0056s9.3 | EAA /ESE Session: Male gonadal function versus general health and vice versa | ECE2018

Does ‘healthy obesity’ exist in andrology?

Corona Giovanni

Introduction: Obesity is a cause of erectile dysfunction (ED) whereas its relationship with male infertility is more conflicting. The term metabolically healthy obesity (HO) has been used to describe an obese phenotype that does not have the burden of any metabolic disorder. The aim of the present study is to analyse the contribution of HO in the pathogenesis of ED and male infertility and to verify the value of HO in predicting major adverse cardiovascular events (MACE).<...

ea0063p1125 | Reproductive Endocrinology 2 | ECE2019

Both comorbidity burden and low testosterone can explain symptoms and signs of testosterone deficiency in men consulting for sexual dysfunction

Rastrelli Giulia , Corona Giovanni , Maggi Mario

Background: Low testosterone (T) is frequent in men with chronical illnesses. The clinical features of T deficiency (TD) overlap with those of chronic diseases. The aim of this study is to evaluate the relative contribution of chronic disease score (CDS) and low T to the presence of TD symptoms.Methods: A consecutive series of 3862 men (aged 52.1±13.1 years) consulting for sexual dysfunction was studied. Several clinical and biochemical parameters w...

ea0035p286 | Clinical case reports Thyroid/Others | ECE2014

One month-Tadalafil 5 mg once daily administration improves clinical and ultrasound parameters of chronic pelvic pain syndrome/lower urinary tract symptoms

Lotti Francesco , Corona Giovanni , Maggi Mario

Introduction: Tadalafil 5 mg once daily (T5od) has been recently approved by the Food and Drug Administration for the treatment of lower urinary tract symptoms (LUTS), along with erectile dysfunction (ED). Recent pooled data analyses demonstrated that T5od–International Prostate Symptom Score related improvements were significant regardless of confounders. In addition, PDE5 inhibitors exert a positive effect on ejaculatory latency. We assessed the clinical outcome of 30 d...

ea0063p1126 | Reproductive Endocrinology 2 | ECE2019

Hormonal predictors of pathologic findings at magnetic resonance imaging in secondary hypogonadal men

Cipriani Sarah , Corona Giovanni , Maggi Mario , Rastrelli Giulia

Introduction: Secondary hypogonadism (sHG) is the most common form of hypogonadism. sHG can arise from any dysregulation of hypothalamic-pituitary (HP) axis due to functional or organic disorders. HP organic disorders are often diagnosed using pituitary magnetic resonance imaging (MRI). However, MRI is an expensive and not widespread exam and it cannot be routinely offered to all sHG patient. The Endocrine Society guidelines suggest MRI scan in sHG men with total testosterone ...

ea0035p179 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2014

Characteristics of compensated hypogonadism in patients with sexual dysfunction

Corona Giovanni , Maseroli Elisa , Rastrelli Giulia , Maggi Mario

Introduction: In the last few years the view that subclinical endocrine disorders represent milder forms of the clinically overt disease has emerged. Accordingly, it has been proposed that compensated hypogonadism represents a genuine clinical subgroup of individuals with late onset hypogonadism (LOH). The aim of the present study is to investigate the association of compensated hypogonadism with clinical and psychological characteristics of male subjects complaining for sexua...

ea0035p201 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2014

Low testosterone syndrome protects from major adverse cardiovascular events in subjects at high cardiovascular burden

Corona Giovanni , Ratrelli Giulia , Maseroli Elisa , Forti Gianni , Maggi Mario

Introduction: The role of testosterone in cardiovascular (CV) health of men is controversial. Several data suggest that hypogonadism is associated with CV mortality but not morbidity. However, recent evidence shows that hypogonadal subjects treated with testosterone replacement therapy have a higher incidence of major adverse CV events (MACE). The aim of this study is to analyse whether the gonadal status might predict MACE incidence according to the previous history of MACE, ...

ea0032p657 | Male reproduction | ECE2013

Impaired masturbation induced erections: a new cardiovascular risk factor for male subjects with sexual dysfunction

Rastrelli Giulia , Boddi Valentina , Corona Giovanni , Forti Gianni , Maggi Mario

Introduction: Erectile dysfunction (ED) is considered an early surrogate marker of silent, or even overt, cardiovascular diseases (CVD). However, epidemiological studies take into account only sexual intercourse-related erections. Although autoeroticism is a very common practice, data on masturbation-induced erections as a possible predictor of major adverse cardiovascular events (MACE) are lacking.Aim: To evaluate the clinical correlates of impaired mas...

ea0090p725 | Reproductive and Developmental Endocrinology | ECE2023

The Role of Testosterone Treatment in Patients with Type 2 Diabetes Mellitus: Results from A Meta-Analysis Study

Vena Walter , Vignozzi Linda , Maggi Mario , Sforza Alessaandra , Pizzocaro Alessandro , Corona Giovanni

Introduction: type 2 diabetes mellitus (T2DM) and hypogonadism are common conditions afflicting the aging male, often present together. The specific role of testosterone (T) replacement therapy (TRT) on glycometabolic profile and body composition, particularly in patients with T2DM, is still the object of an intense debate. The aim of the present study is to meta-analyze the role of TRT in T2DM considering all placebo and non-placebo-controlled randomized clinical trials (RCTs...

ea0041gp187 | Reproduction &amp; Endocrine Disruption | ECE2016

Testosterone supplementation and body composition: results from a meta-analysis of observational studies

Corona Giovanni , Giagulli Vito A , Maseroli Elisa , Vignozzi Linda , Aversa Antonio , Zitzmann Michael , Saad Farid , Maggi Mario

Background: The concept of testosterone (T) supplementation (TS) as a new anti-obesity medication in men with testosterone deficiency syndrome (TDS) is emerging.Aim: To systematically review and meta-analyze available observational and register studies reporting data on body composition in studies on TS in TDS.Methods: An extensive Medline Embase and Cochrane search was performed including the following words: ‘testosterone&#1...