Searchable abstracts of presentations at key conferences in endocrinology

ea0020p425 | Diabetes and Cardiovascular | ECE2009

Effects of oral contraceptives versus no treatment on glucose tolerance and patients’ satisfaction during long time follow up in 69 hirsute patients

Andries Magdalene , Glintborg Dorte , Andersen Marianne

Objective: To evaluate the long term risk for diabetes and insulin resistance in untreated and oral contraceptive (OC) treated hirsute patients.Design: Cross sectional study.Setting: Academic tertiary-care medical centre.Patients: Of 233 Caucasian hirsute women were evaluated during 1997–2002 (baseline) and re-contacted in 2003–2004. Of 159 patients returned questionnaires and 69 attended clinical e...

ea0081p311 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Oxidative stress decreased after six months testosterone treatment compared to placebo in ageing men – a randomized, double-blind trial

Christensen Louise Lehmann , Andersen Marianne , Enghusen Poulsen Henrik , Glintborg Dorte

Background: High oxidative stress is associated with increased morbidity. The effect of testosterone treatment (TT) on oxidative stress in ageing men with reduced bioavailable testosterone is undetermined.Aim: To determine the effect of TT compared to placebo on oxidative stress biomarkers.Methods: Double-blinded, placebo-controlled study in 38 men, aged 60–78 years, with bioavailable testosterone <7.3 nmol/l and waist cir...

ea0022p463 | Female reproduction | ECE2010

Ethnic differences in manifestations of PCOS in 1010 Danish women

Glintborg Dorte , Ravn Pernille , Mumm Hanne , Andersen Marianne

Background: Clinical manifestations, metabolic risk factors and diabetes risk may differ in ethnical subgroups of women with PCOS.Material and methods: A total of 1010 premenopausal women were referred with the diagnoses hirsutism or PCOS during 1997–2008. The patients underwent clinical evaluation, hormone analyses and transvaginal ultrasound (US). Oral glucose tolerance tests (OGTT) (n=500) and ACTH tests (n=434) were performed in a ...

ea0020p467 | Obesity and Metabolism | ECE2009

Plasma monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α are increased in patients with polycystic ovary syndrome and associated with adiposity, but unaffected by pioglitazone treatment

Glintborg Dorte , Andersen Marianne , Richelsen Bjorn , Bruun Jens

Objective: PCOS patients are often characterized by insulin resistance, abdominal obesity, and low-grade inflammation. Insulin sensitizing treatment reduces the inflammatory state, but the effect on serum levels of chemokines such as migration inhibitor factor (MIF), monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1α have not previously been evaluated in PCOS.Research design and methods: Plasma chemokine levels (M...

ea0063oc14.4 | Sex Hormones | ECE2019

Thyroid diseases in danish women with polycystic ovary syndrome

Glintborg Dorte , Hass Rubin Katrine , Nybo Mads , Abrahamsen Bo , Skovsager Andersen Marianne

Background: Polycystic ovary syndrome (PCOS) could be associated with increased risk of thyroid disorders. Possible associations between TSH and cardio-metabolic risk in PCOS are debated.Methods: National Register-based study on women with PCOS in Denmark. 18,476 women had a diagnosis of PCOS in the Danish National Patient Register. PCOS Odense University Hospital (OUH, N=1,146) was an embedded cohort including premenopausal women with PCOS and ...

ea0063gp249 | Disturbances of Reproduction | ECE2019

Maternal 3rd trimester cortisol status was associated with offspring sex and PCOS status. Odense Child Cohort

Andersen Marianne , Jensen Richard , Schmedes Anne , Brandslund Ivan , Kyhl Henriette , Jensen Tina , Glintborg Dorte

Background: Maternal circulating cortisol and 24-h urinary free cortisol levels are up to three times higher in third trimester pregnant women compared to non-pregnant women. Maternal cortisol status could be associated with offspring sex, maternal PCOS and testosterone levels.Aims: To determine predictors of maternal serum (S) and urinary (U) cortisol and cortisone levels during 3rd trimester and to examine associations between maternal cortisol status,...

ea0049gp59 | Cardiovascular &amp; Lipid Endocrinology | ECE2017

Body composition and testosterone determined VO2max in 780 young men – results from the Odense Androgen Study

Christensen Louise Lehmann , Nielsen Torben Leo , Hermann Pernille , Glintborg Dorte , Andersen Marianne

Background: Cardiorespiratory fitness is a measure for physical activity and a prognostic health indicator. However, measurement of maximal oxygen consumption (VO2max) is not possible in clinical practice.Aim: We hypothesized that body composition and testosterone levels could be used as possible determinants of VO2max in young men.Participants and design: The Odense Androgen Study, a population-based, observational study including...

ea0037gp.13.06 | Diabetes and obesity – Translational cardiovascular and obesity | ECE2015

Effects of testosterone replacement therapy on lean body mass, total fat mass, and insulin sensitivity in aging men with type 2 diabetes - a randomised, double-blinded, placebo-controlled trial

Magnussen Line Velling , Glintborg Dorte , Hermann Pernille , Hougaard David M , Hojlund Kurt , Andersen Marianne S

Lowered testosterone levels may be observed in up to 50% of ageing men with type 2 diabetes (T2D). Testosterone replacement therapy (TRT) increases lean body mass in men with lowered testosterone levels and T2D, but the effect of TRT on glucose metabolism has not been evaluated by euglycemic hyperinsulinemic clamp.We used gold standard methods to evaluate the effect of TRT on body composition, insulin sensitivity, and oxidative metabolism in men with T2D...

ea0035p618 | Female reproduction | ECE2014

Changes in body composition following 12 months randomized treatment with metformin vs oral contraceptives vs combined treatment in polycystic ovary syndrome

Glintborg Dorte , Altinok Magda , Mumm Hanne , Hermann Anne Pernille , Ravn Pernille , Andersen Marianne

Background: Central obesity in polycystic ovary syndrome (PCOS) is associated with increased inflammatory markers and increased risk for type 2 diabetes.Aim: To evaluate the long-term effects of metformin (M) and/or oral contraceptives (OC) on fat mass.Research design: Randomized, controlled study.Setting: Outpatient clinic.Methods: 90 patients with PCOS were randomized to 12 months M (...

ea0035p621 | Female reproduction | ECE2014

Pregnancy in women with polycystic ovary syndrome is associated with higher risk of gestational diabetes mellitus, but not of other adverse obstetric outcomes

Mumm Hanne , Glintborg Dorte , Sorensen Jens Aage , Andersen Lise Lotte Torvin , Ravn Pernille , Andersen Marianne

Background: Polycystic ovary syndrome (PCOS) is associated with obesity and increased risk of type 2 diabetes mellitus.Aim: The aim of the present prospective cohort study was to investigate possible associations between PCOS and obstetric outcomes in 199 Danish women with PCOS and 995 controls and to describe the impact of different PCOS phenotypes on the risk of adverse obstetric outcomes.Methods: Women diagnosed with PCOS at Ode...