Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep488 | Thyroid | ECE2020

Simultaneous papillary and medulary thyroid carcinoma – how to approach?

Martins Diana , Guelho Daniela , Vicente Nuno , Ventura Mara , Vieira Alexandra

Introduction: Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are distinct neoplasms, associated with different histological findings. Their coexistence in the same patient is a rare event, requiring a different clinical approach.Clinical case: A 72-year-old patient with no family history of thyroid disease, underwent total thyroidectomy in February 2019, due to toxic multinodular goitre, with no evidence of postoperative complica...

ea0049ep267 | Calcium & Vitamin D metabolism | ECE2017

Acute pancreatitis as the first presentation of primary hyperparathyroidism

Vieira Alexandra , Ferreira Marta , Guelho Daniela , Pereira Teresa , Silva Luis Filipe , Ferreira Estela , Inacio Ana

Background: Hypercalcaemia due to primary hyperparathyroidism is a rare cause of acute pancreatitis, with a reported prevalence of 1.5–8%.Clinical case: A 25-year-old male patient was referred to the Endocrinology outpatient clinic for hypercalcemia diagnosed in the context of acute pancreatitis. He had medical and surgical pathological antecedents of: clavicle fracture after car accident, cholecystectomy and appendectomy, gastroesophageal reflux di...

ea0049ep1362 | Thyroid (non-cancer) | ECE2017

Levothyroxine absorption test in the management of a patient with persistent hypothyroidism

Monteiro Joana , Ferreira Marta , Pires Miguel , Vieira Alexandra , Guelho Daniela , Pereira Teresa , Pinhal Fernanda , Fernandes Celio

Nonadherence to levothyroxine therapy is one cause of persistent hypothyroidism. To distinguish nonadherence from malabsorption, a levothyroxine absorption test (LAT) is sometimes required. The authors report a case of a 60-year-old female patient suffering from hypothyroidism resistant to oral levothyroxine (LT4) substitution after radioiodine therapy for Graves’ disease. Despite the continuous increases of LT4, over 10 years, to a maximum of 1 mg/d...

ea0037gp.22.03 | Pituitary–Therapy of Cushing's disease | ECE2015

Impact of preoperative magnetic resonance in surgical care of patients with Cushing's disease

Guelho Daniela , Martins Diana , Paiva Isabel , Cardoso Luis , Vicente Nuno , Oliveira Diana , Balsa Margarida , Carrilho Francisco

Introduction: Cushing’s disease (CD) is a rare disorder caused by an ACTH-secreting pituitary adenoma. Transsphenoidal surgery (TSS) is the recommended first-line treatment. However, an equivocal or even normal preoperative MRI can preclude the surgical management and the outcome of these patients.Objectives: Evaluate the relationship between preoperative MRI and TSS efficacy in patients with CD.Methods: Retrospective cohort s...

ea0037ep512 | Diabetes (complications & therapy) | ECE2015

Continuous subcutaneous insulin infusion decreases hypoglycaemia during nighttime

Vicente Nuno , Cardoso Luis , Baptista Carla , Barros Luisa , Guelho Daniela , Oliveira Diana , Martins Diana , Carrilho Francisco

Introduction: Continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) are forms of intensified insulin therapy and the most used regimens for type 1 diabetes (T1D). Owing to its continuous basal output, hypoglycaemic events tend to be rarer with CSII. Our goal was to evaluate the differences in nocturnal hypoglycemia between these two treatment strategies.Methods: Retrospective analysis of 61 patients who had performed continu...

ea0035p328 | Clinical case reports Thyroid/Others | ECE2014

Gynecomastia: a rare etiology

Vicente Nuno , Barros Luisa , Saraiva Joana , Moreno Carolina , Guelho Daniela , Cardoso Luis , Carrilho Francisco

Introduction: Gynecomastia is a frequent reason for endocrinology consultation and its correct investigation is pivotal towards a precise diagnosis. We present a clinical case of a rare cause of gynecomastia.Case report: A 56-year-old male was referred to the hospital setting for an endocrinology consultation. He noticed increased breast size for a year, initially tender to palpation, and unquantified weight loss. Neither galactorrhea, nor any nipple dis...

ea0035p609 | Endocrine tumours and neoplasia | ECE2014

Adrenocortical carcinomas: retrospective analysis of the last 22 years

Guelho Daniela , Paiva Isabel , Vieira Alexandra , Saraiva Joana , Moreno Carolina , Vicente Nuno , Cardoso Luis , Carrilho Francisco

Introduction: Adrenocortical carcinoma (ACC) is a rare disease, with a severely adverse prognosis. Clinical reports, even when including a limited number of cases, can contribute to its knowledge. This study aims to characterize patients followed at our department between 1991 and 2013.Methods: Retrospective analysis of the clinical records of patients with pathological confirmation of ACC. Statistical analysis: SPSS21.Results: 22 ...

ea0035p944 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Weight and metabolic profile evolution in patients with treated prolatinomas

Guelho Daniela , Gomes Leonor , Paiva Isabel , Saraiva Joana , Moreno Carolina , Cardoso Luis , Vicente Nuno , Carrilho Francisco

Introduction: The metabolic consequences of hyperprolactinemia and the repercussions of its treatment with dopaminergic agonists are not yet fully understood. This study aims to evaluate the metabolic profile of patients with prolactinomas (prevalence of diabetes mellitus, dyslipidaemia and obesity) and identify the potential variations after treatment with bromocriptine.Methods: Retrospective study of patients followed between 1962 and 2013. Included 17...

ea0032p40 | Adrenal cortex | ECE2013

Autoimmune polyglandular syndrome on a cohort of patients with primary adrenocortical insufficiency

Gouveia Sofia , Ribeiro Cristina , Alves Marcia , Saraiva Joana , Moreno Carolina , Guelho Daniela , Carrilho Francisco

Introduction: On average, 40 to 50% of the patients with autoimmune adrenocortical insufficiency will eventually develop an autoimmune polyglandular syndrome (APS). Our aim was to characterize a population with primary adrenocortical insufficiency (AI) and determine the prevalence of other autoimmune disorders that might establish the diagnosis of APS.Materials and methods: We included patients with primary AI under surveillance at our Department. Those ...

ea0032p355 | Diabetes | ECE2013

Predictive value of HbA1c and glucose fluctuations in hypoglycemia risk in patients with type 1 diabetes

Guelho Daniela , Barros Luisa , Baptista Carla , Paiva Isabel , Gouveis Sofia , Saraiva Joana , Moreno Carolina , Carrilho Francisco

Introduction: Many patients with diabetes experience high variability in glucose concentrations which is associated with a risk of hypoglycemia. The aim of this was to compare the predictive value of HbA1C, mean interstitial glucose (MIG), and glucose variability (GV) in the risk of hypoglycemia in patients with type 1 diabetes (T1D).Methods: Continuous glucose monitoring, using CGMS system, was performed in 130 T1D patients with diabetes duration of 17....