Searchable abstracts of presentations at key conferences in endocrinology

ea0090p500 | Thyroid | ECE2023

The iodine study in pregnancy: no correlation between serum thyroglobulin and urinary iodine concentration

Žabkova Kristyna , Kratky Jan , Jiskra Jan , Krausova Adela

Background: Despite obligatory iodination of salt in the Czech Republic, pregnant women with higher demands on iodine intake may be at risk of iodine deficiency with potentially negative consequences for the course of pregnancy and foetal development. Determination of urinary iodine concentration (UIC) is a conventional but not widely available method used to estimate the iodine status. Based on previous studies, serum thyroglobulin (Tg) could serve as a more convenient marker...

ea0014p292 | (1) | ECE2007

Selenium and its relation to thyroid antibodies, volume and ultrasound texture

Smutek Daniel , Cermakova Ivana , Jiskra Jan , Potlukova Eliska , Tesar Ludvik

Objective: To find a relation between thyroid parameters (thyroxin serum level, thyroid antibodies, thyroid gland volume and ultrasound texture) and serum level of selenium.Background: Selenium deficiency can lead to a decrease of triiode-thyronine in peripheral tissues. Changes in thyroid hormone production can be reflected in followed thyroid parameters.Methods: In 33 patients ultrasound examination of thyroid gland was performed...

ea0090p121 | Endocrine-related Cancer | ECE2023

Thymic Neuroendocrine Tumor Presenting as Cushing’s Syndrome

Krausova Adela , Limanova Zdenka , Sedlačkova Eva , Schutzner Jan , Michalsky David , Hana Vaclav , Jiskra Jan

Introduction: Cushing’s syndrome (CS) is a rare disease with incidence estimated 2-4 cases per million inhabitants per year. ACTH-dependent forms comprise up to 80% of all cases, of which 80% are central and 20% are ectopic, paraneoplastic forms of ACTH-dependent CS. Thymic neuroendocrine tumors (NET) are accounting for 0,4 - 3% of all NET’s with incidence of 0.02/100 000 inhabitants/year. Up to one third of them are hormonally active (secrete adrenocorticotropic hor...

ea0090ep677 | Pituitary and Neuroendocrinology | ECE2023

Prevalence and clinical characteristics of hyponatremia following pituitary surgery

Kosak Mikulas , Netuka David , Masopust Vaclav , Majovsky Martin , Jiskra Jan , Jezkova Jana

Introduction: Hyponatremia is one of the possible complications of pituitary surgery. Mild, asymptomatic hyponatremia can be managed with fluid restriction and oral supplementation, however more profound hyponatremia, especially when symptomatic, can be a reason for hospital readmission and often needs to be treated with saline infusion in ICU.Aims: To estimate prevalence of hyponatremia and provide clinical characteristics in the cohort of patients who ...

ea0037ep984 | Thyroid (non-cancer) | ECE2015

Urinary iodine concentrations in pregnant women with gestational and pregestational diabetes mellitus

Vitkova Hana , Anderlova Katerina , Radimerska Veronika , Kratky Jan , Fait Tomas , Jiskra Jan

Introduction: Urinary iodine concentration (UIC) can reflex recent changes in iodine status and serve as a sensitive marker of current iodine intake. The cut-off value of UIC was determined as the level lower than 100 μg/l. Adequate median urinary iodine for iodine intake in pregnancy is 150–249 μg/l. The aim of this study was to map the situation of iodine intake in pregnant women with pregestational and gestational diabetes and to explore relationship with thy...

ea0035p1013 | Thyroid (non-cancer) | ECE2014

Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women.

Vitkova Hana , Jiskra Jan , Springer Drahomira , Limanova Zdenka , Telicka Zdenek , Bartakova Jana , Potlukova Eliska

Introduction: Anti-C1q antibodies have been implicated in the pathogenesis of systemic lupus erythematosus. We have previously shown that anti-C1q antibodies are also linked to autoimmune thyroid disorders (AITD). The aim of this study was to assess the occurrence of anti-C1q antibodies in pregnant women with AITD.Methods: Serum anti-C1q antibodies were measured during the 9–11th gestational weeks in 103 pregnant women screened positive for AITD, an...

ea0032p1011 | Thyroid (non-cancer) | ECE2013

Latent toxoplasmosis: a novel risk factor for autoimmune thyroid diseases in pregnancy?

Potlukova Eliska , Prochazkova Lucie , Jiskra Jan , Limanova Zdenka , Springer Drahomira , Calda Pavel , Flegr Jaroslav , Kankova Sarka

Introduction: Latent toxoplasmosis, a zoonosis caused by protozoan Toxoplasma gondii, is the most widespread human parasitosis in developed countries (prevalence 20–80%). Upon infection, T. gondii stays in human organism lifelong. It has been linked to several autoimmune diseases, including autoimmune thyroid disease (AITD). The aim of our study was to assess the impact of latent T. gondii infection on the prevalence of AITD in pregnancy with re...

ea0032p1012 | Thyroid (non-cancer) | ECE2013

Iodine status in women after early miscarriages in the Czech Republic

Jiskra Jan , Fait Tomas , Bilek Radovan , Bartakova Jana , Potlukova Eliska , Springer Drahomira , Telicka Zdenek , Limanova Zdenka

Background: Early miscarriages are of multifactorial origin. Subclinical thyroid dysfunction belongs to the common causes. Thyroid dysfunction in pregnancy is caused mainly by thyroid autoimmunity and/or iodine deficiency. The Czech Republic belongs to countries with sufficient iodine intake. The aim of the study was to determine iodine status in women after early miscarriages (n=183) and to compare it with randomly chosen age-comparable euthyroid women without previo...

ea0022p787 | Thyroid | ECE2010

Serum levels of antibodies to thyroid peroxidase in women after miscarriages in comparison with the 1st trimester of pregnancy and healthy non-pregnant women

Jiskra Jan , Fait Tomas , Limanova Zdenka , Antosova Marie , Telicka Zdenek , Springer Drahomira , Potlukova Eliska

Background: Etiology of infertility and miscarriages is multifactorial. Negative impact of overt thyroid dysfunction on fertility, pregnancy and development of offspring is known. Moreover, even presence of euthyroid autoimmune thyroid diseases may increase risk of miscarriages. The prevalence of positive antibodies to thyroid peroxidase (TPOAb) ranges 9–39% in women with recurrent miscarriages and 0–37% in controls. The aim of the study was to compare serum concentr...

ea0014p304 | (1) | ECE2007

The prevalence of anti-C1q antibodies is increased in autoimmune thyroid disorders

Potlukova Eliska , Jiskra Jan , Sandova Petra , Limanova Zdenka , Smutek Daniel , Mareckova Helena , Antosova Marie , Trendelenburg Marten

Background: Autoantibodies directed against complement C1q (anti-C1q) have been described in a number of systemic autoimmune disorders. In systemic lupus erythematosus, they are strongly associated with proliferative lupus nephritis. However, no study has focused on the presence of anti-C1q in organ specific autoimmune disorders. The aim of this study was to determine the prevalence of anti-C1q in autoimmune thyroid disorders (AITD).Methods: Serum levels...