Endocrine Abstracts

Purpose: Although some studies presented good outcome of Radiofrequency Ablation (RFA) for Papillary Thyroid microcarcinoma (PTMC), its benefit has not been fully elucidated. The purpose of our study was to report the results from a prospective study investigating efficacy and safety of RFA in active surveillance candidate for low-risk PTMC. Materials and Methods: Since November 2018, RFA has been prospectively performed in active surveillance candidates...

Purpose: This retrospective study is intended to determine the dose of radioactive iodine using thyroglobulin levels measured after two weeks of thyroid hormone withdrawal in patients with differentiated thyroid cancer. Methods : Patients who were diagnosed as differentiated thyroid cancer and treated with radioiodine after total thyroidectomy were enrolled. Serum thyroglobulin test (preTG; ng/dl) was performed 1 week before radioiodine treatment and 2 w...

Purpose: This retrospective study is evaluated the efficacy of three doses of I-131 (1110 MBq vs 3700 MBq vs 5550 MBq) in differentiated thyroid carcinoma patients with cut-off serum thyroglobulin (TG) level after two weeks of thyroid hormone withdrawal for postoperative thyroid remnant ablation.Methods: A total of 97 patients with differentiated thyroid cancer treated with total thyroidectomy and radioactive iodine (RAI) therapy...

Objective: To analysis the clinical pathological characteristics and 131I curative responses of familial differentiated thyroid cancer(FDTC) and sporadic differentiated thyroid cancer(SDTC).Methods: A total of 112 FDTC patients(79 females, 33males, age(41.3±15.6)) and 1000 SDTC (658 females, 342males, (44.2±13.9)) who underwent 131I therapy in Department of Nuclear Medicine in our hospital between January 2011 and July 2021 we...

Objectives: Many paediatric diabetes units in the UK have introduced 24 h telephone support to encourage self-management to reduce Emergency Department (ED) attendances and admissions. The UK national audit collects information on acute paediatric diabetic admissions; but there is no data available on ED attendances in this group. We undertook a retrospective audit of ED attendances as part of a baseline service evaluation of our newly introduced 24 h support service.<p cl...

Numerous epidemiological studies worldwide have shown a strong association between low birth weight and an increased risk of developing cardiometabolic disease, including hypertension. Excessive fetal exposure to glucocorticoids has been hypothesised to mediate this relationship. Here, we have used an established rodent model – in which dexamethasone, a synthetic glucocorticoid that readily crosses the placenta, is administered to pregnant Wistar rats during the last trim...

Introduction: 3βHSD catalyses the formation of Δ4-3-ketosteroids including progesterone and androgens. Levonorgestrel (LNG) is an androgenic progestogen used in the LNG intra-uterine system (LNG-IUS). 17βHSD-5 is involved not only in androgen and oestrogen metabolism, but also has 3β-reductase activity.Objective: To determine expression patterns of 3βHSD-1 and -2, and 17βHSD-5 in human endometrium across the normal menstrual...

In this study, human neural stem cells (hNSCs) were used to cancer treatment strategy for anaplastic thyroid cancer (ATC) owing to their tumor tropic properties. Cytosine deaminase (CD) can convert a prodrug, 5-fluorocytosine (5-FC), to drug, 5-fluorouracil (5-FU), which inhibits tumor growth through DNA synthesis inhibition. Also, IFN-β expression suppresses tumor growth by apoptotic process. Then, we investigated tumor inhibition effect of hNSCs in vitro and <e...

Purpose: To evaluate the association between ultrasonography (US) feature of thyroid gland and thyroid function in pediatric and adolescent populations with autoimmune diffuse thyroid diseases (AITD).Methods: From 2000 to 2020, we reviewed thyroid ultrasound (US) images and thyroid function statuses in 133 children and adolescent AITD patients. Our review of the images focused on decreased echogenicity and heterogeneity, which were classified into four g...

Introduction: Bariatric surgery was shown to treat obesity and decrease cardiovascular risk such as metabolic syndrome, diabetes, and hypertension. In individuals living with HIV, bariatric surgery can alter oral bioavailability of anti-viral therapy through its impact on the intestinal pH, intestinal transit time and first pass mechanism. This can have adverse impact on CD4 count and viral load (VL). Nevertheless, numerous studies highlight that bariatric surgery does not hav...