Endocrine Abstracts

We present a case report of a young female patient with hypercalcemia-induced acute necrotizing pancreatitis as first manifestation of a benign parathyroid adenoma.Case: A 46-year-old female presented at the emergency room with a sudden attack of severe epigastric pain and vomiting. Clinical examination revealed a severely ill patient, a silent abdomen which was distended with painful percussion and palpation of the epigastrium. Blood analysis showed sig...

Objective: To test the utility of the artificial learning algorithms using magnetic resonance (MR) images of the pituitary gland in predicting the prognosis of prolactinoma.Methods: This single-center, retrospective study was conducted in the Pituitary Center of a tertiary care university hospital. A total of 224 images derived from 38 patients with treatment-refractory prolactinoma, 23 patients with prolactinoma remission and 51 healthy individuals were...

Introduction: Incretin based therapeutics have commonly been used in the last years for the management of patients with type 2 diabetes mellitus (DM). Linagliptin is a member of “dipeptidyl peptidase 4” (DPP-4) inhibitors and often preferred owing to some advantages over the others. We present a diabetic case developing skin findings after the initiation of linagliptin.Case: 66 year-old woman with a history of type 2 DM for 10 years was admitte...

Wegener granulomatosis is an antineutrophil cytoplasmic antibody (cANCA)-associated, multi-system, necrotizing granulomatous vasculitis. Inflammation of nasal or oral mucosa, lung and kidney involvements are typical in the course of the disease. It was first described by Friedrich Wegener in 1939, and has an incidence rate of 1 in 100 000 people, often observed in individuals aged between 25 and 50 years, but uncommon in children and adolescent. In rare cases, pituitary involv...

Aims: In this study, we examined the relationships between levels of adipocytokines and traditional and non-traditional cardiovascular risk markers in patients with type 2 diabetes mellitus (T2DM).Methods: Serum leptin, resistin, adiponectin, visfatin, high sensitive C-reactive protein (hsCRP), homocystein, asymetric dimethylarginine (ADMA), fasting glucose, insulin, glycated haemoglobin (HbA1C) and full lipid and lipoprotein profile, systolic...

Objective: There is little data available regarding the effects of male sex hormones on cardiac autonomic function. The aim of this study is to evaluate the association between male sex steroids and cardiac autonomic function by comparing heart rate variability (HRV) parameters of young male hypogonadotropic hypogonadism patients to those of healthy controls.Design: The study consisted of 22 male hypogonadotropic hypogonadism patients (mean age 20.8&#177...

Diabetes mellitus (DM) includes a group of carbohydrate metabolism disorders that is characterized by hyperglycemia and leads long-term macro- and microvascular complications. Also siblings of type 2 diabetic patients have increased relative risk of micro and macrovasculer outcome of DM even though their plasma glucose levels in normal range. Genetically determined hyperinsulinemia, insulin resistance and associated dyslipidemia have crucial role in the processes of vascular a...

Accelerated coronary and peripheral vascular atherosclerosis is one of the most common and chronic complications of diabetes mellitus. A relatively recently analysed aspect of coronary artery disease in this condition is its silent nature. We studied silent myocardial ischaemia (SMI) in unselected consecutive middle aged asymptomatic patients with type II diabetes by treadmill exercise test.Ninety four asymptomatic type II diabetics between the ages 36 a...

Silent thyroiditis is characterized by the destructive thyroid inflammation and is considered to be a chronic autoimmune thyroid disease, although the etiology could not have been fully explained. On the other hand, Graves’ disease is autoimmune phenomena as well as silent thyroiditis and silent thyroiditis has been classified as part of the spectrum of Graves’ disease. Although, the thyroid stimulating antibody (TSAb) are found positive in most of Graves’ disea...

Objective: It has been argued that salivary alpha-amylase (sAA) is a potential indirect sympathoadrenal medullary (SAM) system activity marker. This study aimed to look at sAA to assess the sympathetic nervous system in acromegaly patients.Subjects and Methods: A total of 31 individuals with acromegaly and 30 controls were enrolled in this prospective, single-center investigation. Saliva samples were taken from individuals with acromegaly and controls in...