Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp232 | Thyroid Cancer | ECE2017

Germ-line mutations in RET-790 and RET-791 codons (exon 13) among subjects with sporadic medullary thyroid cancer

Katalinic Darko , Solter Miljenko , Nikolac Nora

Background: Medullary thyroid carcinoma (MTC) is a rare calcitonin producing neuroendocrine tumour that originates from parafollicular C-cells of the thyroid gland. RET proto-oncogene germline mutations are crucial for the onset and the progression of MTC, and the occurrence of single nucleotide polymorphisms could predispose the clinical course of disease. The objective of this study was to evaluate possible differences in clinical presentation among patients with/without RET...

ea0049ep209 | Thyroid cancer | ECE2017

Clinical relevance of RET proto-oncogene variants L769L and S836S (exon 11, 13, 14, and 15) in patients with sporadic medullary thyroid carcinoma

Katalinic Darko , Solter Miljenko , Nikolac Nora

Background: Medullary thyroid cancer (MTC) makes up to 5–10% of all cases of thyroid malignancies. The clinical course of MTC varies from an extremely indolent tumour to an aggressive variant that is associated with a high mortality rate. RET proto-oncogene germline mutations are crucial for the onset and the progression of MTC. The aim of this study was to evaluate the L769L (subgroup L) and S836S (subgroup S) allele frequencies in patients with sporadic MTC (group A, <e...

ea0037ep897 | Thyroid cancer | ECE2015

RET M918T-exon 16 mutation in subjects with sporadic medullary thyroid cancer (sMTC)

Katalinic Darko , Solter Miljenko , Nikolac Nora

Medullary thyroid cancer (MTC) is a form of thyroid carcinoma which originates from the calcitonin-secreting neuroendocrine parafollicular cells of the thyroid. It accounts for 5–10% of all thyroid cancers, and it mostly occurs as a sporadic entity (sMTC), but a familial pattern is also possible. Somatic mutations of RET are reported in 20–80% of sMTCs. The majority of MTCs harbour a RET M918T-exon 16 mutation. In sporadic MTCs the RET gene is mutated in codon 918, w...

ea0014p146 | (1) | ECE2007

Time necessary to achieve the maximum effect of goserelin, LH-RH agonist, in therapy of hormone dependent breast cancer

Murgic Jure , Matovinovic Martina , Fabijanic Lucija , Katalinic Darko , Vrkljan Milan

Nearly one third of women diagnosed with invasive breast cancer are younger than 50 years with regular menstrual cycles. 60% of these tumors express estrogene and progesterone receptors. Common treatment procedure is surgery followed by chemotherapy, radiotherapy and hormone therapy. Often in younger patients chemotherapy causes permanent amenorrhoea. In case that menses afterwards occurs ovarial suppression is needed, mostly by goserelin, LH-RH agonist. The principle of thera...

ea0056gp39 | Adrenal cortex | ECE2018

Gene mutation analysis and overal survival among the patints with neuroendocrine tumors of the lung and gastroenteropancreatic neuroendocrine tumors

Katalinic Darko , Aleric Ivan , Vcev Aleksandar , Bildat Stephan , Soerensen Lilly

Introduction: Neuroendocrine tumors (NET) arise from tissue mucosal cells known as enterochromaffin cells. The clinical behavior of NET has been recognized over the past 30 years and genome analysis are needed for further follow up. Here we conduct integrated genome analyses on data from chromosomal gene copy number and transcriptome sequencing as well as analysis of overal survival of patients diagnosed with NET.Material and methods: The study accrued 6...

ea0073pep3.3 | Presented ePosters 3: Pituitary and Neuroendocrinology | ECE2021

Insulinoma-associated protein 1 (INSM1) may serve as a sensitive and specific immunohistochemical and molecular biomarker of neuroendocrine differentiation in pancreatic neuroendocrine tumors (PNETs)

Katalinic Darko , Aleric Ivan , Vcev Aleksandar , Kattner Elke

IntroductionInsulinoma-associated-1 (INSM1), encoded by the INSM1 gene is key factor in pancreatic endocrine, sympatho-adrenal and pan-neurogenic development. It has also been identified in multiple tumors of neuroendocrine origin but not thoroughly investigated as a potential neoplastic biomarker. The aim of the study was to evaluated INSM1 as a semiquantitative immunohistochemical biomarker as well as quantitative reverse transcriptase polymer...

ea0081ep982 | Thyroid | ECE2022

Association between vitamin D serum concentration and development of papillary thyroid cancer

Katalinic Darko , Aleric Ivan , Vcev Aleksandar , Solter Miljenko , Ranogajec Irena , Toetome Lars

Purpose: Papillary thyroid cancer (PTC) is the most common thyroid and endocrine malignancy worldwide. Vitamin D (calciferol or 25-hydroxyvitamin D) (25(OH)D) has been postulated as a key modulator in several cancer-related pathways, although its contribution to PTC still remain controversial. The aim of the study was to analyse the correlation between 25(OH)D serum levels and 25(OH)D insufficiency as well as the risk of development of PTC and its variants: classical type (CV-...

ea0081ep1041 | Thyroid | ECE2022

Papillary thyroid cancer and its variants - genomic evidence and clinical significance

Katalinic Darko , Aleric Ivan , Vcev Aleksandar , Solter Miljenko , Ranogajec Irena , Toetome Lars

Purpose: Papillary thyroid cancer (PTC) accounts for approximately 80% of all thyroid cancers and is defined by its unique cytologic and histologic features. Mutations of the RET and BRAF/V600 genes are found in nearly 70% of PTC cases. They are able to trigger the activation of mitogen-activated protein kinase pathways and to promote neoplastic cell proliferation. Genetic events may further lead to numerous different cell variants of PTC which may be identified via t...

ea0063p447 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Down-regulation of the Ataxia Telangiectasia Mutated Gene (ATM) is associated with increased metastatic potential and decreased overal survival in patients diagnosed with gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

Katalinic Darko , Aleric Ivan , Vcev Aleksandar , Mirat Jure , Soerensen Lilly , Bildat Stephan

Introduction: Neuroendocrine tumors (NETs) are rare tumours that develop in cells of the neuroendocrine system. They comprise a heterogeneous group of neoplasms that range from the benign and multi-focal to the highly malignant and metastatic. Here we conduct itegrated genome and immunohistochemistry analysis (IHC) of the Ataxia Telangiectasia Mutated Gene (ATM) as well as analysis of overal survival in patients diagnosed with NETs.Material and Methods: ...

ea0035p1109 | Thyroid Cancer | ECE2014

Ca 19-9: is there a role for potential new biomarker for medullary thyroid cancer?

Katalinic Darko , Santek Fedor , Juretic Antonio , Stern-Padovan Ranka , Nikolac Nora , Grah Josip Joachim , Plestina Stjepko

In the recent years, knowledge about cancer biomarkers has increased tremendously providing great opportunities for improving the diagnosis, prognosis and treatment of cancer patients. In clinical practice, the levels of serum calcitonin, and carcinoembryonic antigen (CEA) are important during follow-up for patients with medullary thyroid cancer (MTC). Carbohydrate antigen 19-9 (CA 19-9), routinely used in the monitoring of pancreatic, hepatobiliary, and colon carcinoma, also ...