Endocrine Abstracts

Introduction: Parathyroid surgical therapy differs because the glands are small and of variable number and location. Although localization studies have improved greatly, we may not reliably determine the number and location of all diseased glands preoperatively. Ultrasonography (US) is the most widely used imaging method. In this study, we aimed to demonstrate how the surgical outcomes change when the surgeon accompanies the endocrinologist during preoperative ultrasonography ...

Introduction: Parathyroid cancer (PC) is rare accounting for <1% of all presentations. Tumors that demonstrate these atypical features and do not fulfill criteria for carcinoma can be classified as atypical adenomas (APA). Herein we aimed to evaluate the clinical and biochemical features of the patients with an atypical parathyroid adenoma or carcinoma and compare it with benign parathyroid adenomas.Method: Twenty-eight patients who were operated for...

Introduction: Primary hyperparatyhyroidism (PHPT) is usually caused by single or multiple adenomas and cancer is rare accounting for <1% of all presentations. The presence of certain cytological and architectural features such as adherence to adjacent organs, a solid growth pattern, broad bands of fibrosis, cytological atypia, and an irregular growth contour do not indicate malignancy but are recognised as atypical features encountered more commonly in malignant than benig...

Introduction: Neoplasms of the thyroid gland are classified according to the cell that it originates and commonly they originate from follicular or parafollicular C cells. The most common differentiated thyroid cancers (DTC) are papillary and follicular carcinomas. Coexistence of two different histological types of primary follicular thyroid neoplasm is a rare condition. There are previous reports of concomitant medullary and papillary thyroid cancers. However, there is scarce...

Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is associated with neoplasia and hyperfunction of the parathyroid and pituitary glands, pancreatic islet cells, and neuroendocrine cells of the gut. Many authors advocate routine subtotal or total parathyroidectomy and autotransplantation for these patients. Here we demostrate negative MEN1 and MEN4 gene mutation analysis in a case with prolactinoma and a large parathyroid adenoma that could not be localized with preope...

Aim: Radioactive iodine (RAI) is one of the treatment approaches in Graves and toxic nodular or multinodular goiter (TNG/TMNG) with low cost and high efficacy. In this study, we aimed to evaluate ultrasonographical and cytological features of thyroid nodules in patients who were treated with radioactive iodine for hyperthyroidism years ago.Methods: Patients who had a history of RAI treatment for hyperthyroidism and had thyroid nodules that were evaluated...

Introduction: Although, familial medullary thyroid cancer is a known condition, familial papillary thyroid cancer (PTC) is a rare and less well described clinical entity. While some studies suggest more aggressive features in familial PTC, some do not support these findings. We aimed to compare ultrasonographical, cytopathological and histopathological results of patients with familial and sporadic PTC.Methods: Data of 194 patients diagnosed with PTC his...

Introduction: Incidental thyroid carcinoma (ITC) in patients operated on for a benign disease is frequent. ITC characteristics in patients operated for malign disease, but not sampled by fine needle aspiration (FNA) or seen in ultrasonography, is unknown. We aimed to compare ITC with nonincidental ITC (NITC) in this study.Material and method: Retrospective analyses of 918 individual patients who were operated for benign and malign thyroid disease in our ...

Introduction: Primary hyperparathyroidism (PHP) is a highly prevalent disease, which is treated most effectively by surgery. Postoperative hypocalcaemia, a morbidity of surgical treatment of parathyroidism, can prolong the hospital stay. The aim of this study was to identify the factors predictive of hypocalcaemia and hungry bone syndrome (HBS) in patients who undergo parathyroidectomy due to PHP.Materials and methods: Preoperatively and on days 1 and 4,...

Introduction: Primary hyperparathyroidism (pHPT) is a common endocrine disease mainly caused by single or multiple hyperfunctioning parathyroid lesions. In 2–7% of cases, surgery is not curative at first operation and reoperation is required. Ultrasonography and sestamibi scan are the most widely used methods for identification of the culprit parathyroid gland with the disadvantage of high false positives caused by other cervical pathologies. Herein we aimed to search the...