Searchable abstracts of presentations at key conferences in endocrinology

ea0056p880 | Pituitary - Clinical | ECE2018

Usefulness of stereotactic radiotherapy in acromegalic patient resistant to conventional treatment

Brominska Barbara , Komarowska Hanna , Ruchala Marek

Introduction: Acromegaly is a rare, chronic disease characterized by increased secretion of growth hormone, most commonly by autonomous adenoma of the anterior pituitary. Mortality is 2–3 times higher than in general population. So that, it is vital to achieve biochemical cure. We present a case in which patient was successfully treated with stereotactic radiotherapy (SRT)- CyberKnife and preserved pituitary function.Case report: A 39-years old men ...

ea0020p591 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The correlations of ghrelin concentrations and lipid profile in patients with acromegaly

Jaskula Magdalena , Wasko Ryszard , Komarowska Hanna , Dziubandowska Aleksandra , Sowinski Jerzy

The role of ghrelin in the pathogenesis of acromegaly is doubtful. Ghrelin also regulates glucose and adipose tissue metabolism. It has not been demonstrated whether it contributes to the development of metabolic complications of acromegaly.Aim: The aim of the study was to assess: (1) whether serum concentrations of total and acyl ghrelin in patients with acromegaly differ in relation to coexisting metabolic complications (hypercholesterolemia, hyperinsu...

ea0081ep101 | Adrenal and Cardiovascular Endocrinology | ECE2022

Visfatin as a potential serum marker of adrenal gland cancers

Sawicka-Gutaj Nadia , Komarowska Hanna , Derwich Aleksandra , Wrotkowska Elżbieta , Ruchala Marek

Introduction: There are not many studies specifying the role and contribution of adipocytokines in biology of adrenal gland cancer. Many research show correlation between increased level of serum visfatin and malignant potential, stage progression and prognosis. Visfatin/NAMPT overexpression has been found in a various type of malignances. So far, to the best of knowledge, this is the first research studying the role of visfatin in diagnosis of adrenal cortical carcin...

ea0049ep388 | Clinical case reports - Thyroid/Others | ECE2017

Diabetic patient with suppurative thyroiditis caused by Salmonella enterica complicated with acute kidney injury

Hernik Aleksandra , Szczepanek-Parulska Ewelina , Falkowski Bogusz , Komarowska Hanna , Wejman-Matela Anna , Drews Michal , Ruchala Marek

Incidence of acute thyroiditis is about 0.1% of thyroid gland conditions requiring surgical treatment. Main pathogen causing acute thyroiditis is Staphylococcus aureus while Salmonella enterica is extremely rare.Herewith we report a 61-year-old obese woman with sore throat and fever. She had chronic atrial fibrillation, hypertension, and well-controlled type 2 diabetes mellitus (HbA1C 5.5%) for 3 years (on metformin and gliclazide). Her...

ea0056p854 | Pituitary - Clinical | ECE2018

The metabolic disturbances in acromegaly patients in relation to total, acylated and unacylated ghrelin

Komarowska Hanna , Brominska Barbara , Sawicka-Gutaj Nadia , Jaskula-Switek Magdalena , Wasko Ryszard , Ruchala Marek , Kotwicka Malgorzata

Purpose: Acromegaly is a disease characterized by the excessive secretion of GH. Clinically, it is manifested by overgrowth of tissues and internal organs, which leads to characteristic phenotype. Patients with active acromegaly usually have impaired glucose metabolism. It significantly improves after achieving remission of the disease. Adversely, disturbances in lipid profile are not altering. Moreover, these parameters are even worse in successfully treated patients. Ghrelin...

ea0014p647 | (1) | ECE2007

Immunohistochemical evaluation of ghrelin expression in polycystic ovaries in patients with PCOS.

Komarowska Hanna , Wasko Ryszard , Iwanik Katarzyna , Majewski Przemyslaw , Szymankiewicz Alina Warenik , Rafinska Ludmila , Jaskula Magdalena , Sowinski Jerzy

Ghrelin is an endogenous ligand of the GH secretagogue receptor. The influence of ghrelin on different organs has been studied recently e.g. in the regulation of pituitary hormone release, regulation of energy homeostasis, glucose metabolism and insulin secretion, cell proliferation and reproductive function.The etiology of PCOS has not been firmly explained, althought several pathways have been implicated – the regulatory pathways of steroid hormon...

ea0037ep956 | Thyroid (non-cancer) | ECE2015

The role of antithyroglobulin, antiperoxidase and anti-TSH autoantibodies in amiodarone induced thyrotoxicosis or amiodarone induced hypothyroidism (a two-center study)

Czarnywojtek Agata , Zgorzalewicz-Stachowiak Malgorzata , Fichna Marta , Wolinski Kosma , Plazinska Maria Teresa , Stangierski Adam , Gut Pawel , Miechowicz Izabela , Komarowska Hanna , Czepczynski Rafal , Krolicki Leszek , Ruchala Marek

Purpose: In the recent study it has been reported, that elevated serum concentrations of TSH receptor (TSH-R), antithyroglobulin (Tg), antiperoxidase (TPO) autoantbodies (Abs) may be observed in the subjects treated for amiodarone induced thyrotixicosis (AIT) type I, decreased in type II of AIT, or changed in amiodarone induced hypothyroidism (AIH). This study was done to analyse the changes of Tg-Abs, TPO-Abs and TSH-R-Abs titer in euthyroid, hyperthyroid (AIT), and hypothyro...

ea0056p1049 | Thyroid (non-cancer) | ECE2018

Dependency between vitamin D3 and serum titers of the thyroid autoantibodies in smoking cigarettes patients with Graves’ disease - one year follow-up - preliminary study

Plazinska Maria Teresa , Czarnywojtek Agata , Zgorzalewicz-Stachowiak Malgorzata , Sawicka-Gutaj Nadia , Czarnocka Barbara , Wolinski Kosma , Maciejewski Adam , Komarowska Hanna , Karlinska Maria Maria , Ruchala Marek , Krolicki Leszek

Purpose: The aim of this study was to evaluate the association between the serum vitamin D level and changes in the titers of the anti-TSH receptor (TSHR), antithyroglobulin (Tg), and antiperoxidase (TPO) autoantibodies (Abs) in smoking cigarette Graves’ disease (GD) patients, with and without the vitamin D supplementation.Methods: The study was performed from January 2015 to December 2016. It consisted of 136 patients. The intensity of nicotinism w...

ea0056p128 | Endocrine tumours and neoplasia | ECE2018

Ghrelin is overexpressed in adrenal cancers and stimulates proliferation and migration of ACC cell line.

Komarowska Hanna , Rucinski Marcin , Tyczewska Marianna , Sawicka-Gutaj Nadia , Szyszka Marta , Hernik Aleksandra , Klimont Anna , Milecka Paulina , Migasiuk Laura , Biczysko Mateusz , Idasiak-Piechocka Ilona , Karczewski Marek , Czarnywojtek Agata , Ruchala Marek

Purpose: Adrenal cancers are relatively rare, but they have poor prognosis. IGF2 has been confirmed as a factor of adrenal tumors development. Recent data indicate that ghrelin may be an essential factor in cancerogenesis. The aim of our study was to assess ghrelin expression in adrenal tumors, and to investigate the relationship between ghrelin, IGF2 and the clinicopathological characteristics. We also investigated the influence of ghrelin on adenocarcinoma cell line prolifer...